1.In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule
Rahimiesboei BAHMAN ; Fakhar MAHDI ; Chabra AROONA ; Hosseini MAHBOOBEH
Asian Pacific Journal of Tropical Biomedicine 2013;(10):811-815
Objective: To determined the antiparasitic activity of the isolated chitosan from Penicillium viridicatum, Penicillium aurantiogriseum and commercial chitosan against protoscolicidal of hydatid cysts were determined.
Methods:After isolating chitosan from fungal cell walls, four concentrations (50, 100, 200, 400μg/mL) of each type of prepared chitosan and commercial chitosan were used for 10, 30, 60, and 180 min, respectively.
Results: Among different type of chitosan, commercial chitosan with the highest degree of deacetylation showed high scolicidal activity in vitro. Fungal chitosan could be recommended, as good as commercial chitosan, for hydatic cysts control.
Conclusions:It seems to be a good alternative to synthetic and chemical scolicidal.
2. Promising antileishmanial effectiveness of doxorubicin and Doxil against Leishmania major: An in vitro assay
Azar SHOKRI ; Sajede SADJJADIAN ; Javad AKHTARI ; Masoud KEIGHOBADI ; Azar SHOKRI ; Mahdi FAKHAR ; Saeed Hosseini TESHNIZI ; Saeed EMAMI
Asian Pacific Journal of Tropical Medicine 2017;10(6):544-548
Objective To evaluate the effect of doxorubicin and its pegylated liposomal formulation (Doxil, Caelyx) on in vitro susceptibility of promastigote and amastigote stages of Leishmania major. Methods Throughout in vitro assays the IC