No abstract available.
Magnesium Sulfate* ; Magnesium* ; Torsades de Pointes*

Study on 410 pregnant women had babies at Obstetric Department, Sa Dec General Hospital between March and August 2002, who underwent episiotomy or had perineal laceration, followed by swelling, edema, and painful sutures. All participants were divided into 2 groups: group of women had born babies at even dates were treated by 25% magnesium sulfate cold solution, and group of women had born babies at odd dates treated by cold placebo pad. Results: magnesium sulfate solution has endosmotic effect, leads to reduce swelling and edema. Pain relief effects were similar between 2 groups but magnesium sulfate cold solution was likely to have faster improvement in perineal edema and urination. Using cold magnesium sulfate saturated pad for nursing care after episiotomy is simple, easy method and has fast effects.
Episiotomy ; Magnesium Sulfate ; Nursing Care

No abstract available.
Female ; Magnesium Sulfate* ; Magnesium* ; Obstetric Labor, Premature* ; Pregnancy ; Ritodrine*

OBJECTIVE: This study was designed to compare the efficacy and safety of the ritodrine hydrochloride alone with combined treatment with magnesium sulfate in the management of preterm labor. METHODS: One hundred thirty three singleton pregnancies with preterm labor were treated with either ritodrine hydrochloride (n=97) or ritodrine hydrochloride and magnesium sulfate (n=36). The principal outcomes assessed were delay of duration, maternal-fetal side effects, and fetal outcome. RESULTS: The treatment to delivery time was not statistically different between the ritodrine group and the combined magnesium sulfate group (mean+/-SD 10.7+/-13.0 days, 8.6+/-9.1 days, respectively). The proportion delivered after 48 hours, 72 hours, or 7 days was also not statistically different between two groups (29% vs. 22%, 40% vs. 39%, 60% vs. 64%, respectively). No statistical difference was found in the side effects of treatment or fetal outcomes. CONCLUSION: There was no significant difference in efficacy and safety between ritodrine hydrochloride and combined treatment with magnesium sulfate in the management of preterm labor.
Female ; Magnesium Sulfate* ; Magnesium* ; Obstetric Labor, Premature* ; Pregnancy ; Ritodrine*

OBJECTIVE: This study aimed to estimate the association between total and ionized magnesium, and the changes in serum magnesium and calcium levels in patients with preterm labor during magnesium sulfate (MgSO4) administration. METHODS: The study population included 64 women who were candidates for intravenous MgSO4 treatment for preterm labor. Serial blood samples were taken and measured total magnesium (T-Mg), ionized magnesium (I-Mg), total calcium (T-Ca), and ionized calcium (I-Ca) levels every one-week interval (1st, 2nd, 3rd). RESULTS: There was no significant difference in T-Mg and I-Mg levels during MgSO4 administration (P>0.05). There was no significant difference in T-Ca and I-Ca levels during MgSO4 administration (P>0.05). Compared before and after administration of MgSO4, T-Mg and I-Mg levels and T-Ca levels were changed allow statistically significant (P < 0.05). But, there was no significant difference in the I-Ca serum levels before and after MgSO4 administration (P=0.495). The I-Mg levels for patients with adverse effect were higher than other group but did not reach statistical significance (P>0.05). There was significant correlation between levels of I-Mg and T-Mg (I-Mg=0.395×T-Mg+0.144, P < 0.01). CONCLUSION: There were no significant differences in serum Mg and Ca levels during MgSO4 administration for preterm labor. Compared to the before and after administration of MgSO4, only I-Ca levels were not substantially changed. There are significant correlations between I-Mg and T-Mg levels during administration of MgSO4 and I-Mg level seemed to have more correlation with adverse effect than T-Mg.
Calcium ; Female ; Humans ; Magnesium Sulfate ; Magnesium ; Obstetric Labor, Premature ; Pregnancy

BACKGROUND: Perioperative magnesium sulfate (MgSO4) is used for analgesic, anti-arrhythmic, and obstetric purposes. The effects of MgSO4 on the neuromuscular blockade (NMB) induced by rocuronium, and the sugammadex reversal thereof, have not been clearly quantified. We investigated the effect of various MgSO4 concentrations on the NMB by rocuronium, and sugammadex reversal, in isolated left phrenic nerve hemi-diaphragm (PNHD) preparations from the rat. METHODS: Rat PNHD preparations were randomly allocated to one of four groups varying in terms of MgSO4 concentration (1, 2, 3, and 4 mM, each n = 10, in Krebs solution). The train-of-four (TOF) and twitch height responses were recorded mechanomyographically. The preparations were treated with incrementally increasing doses of rocuronium and each group’s effective concentration (EC)50, EC90, and EC95 of rocuronium were calculated via nonlinear regression. Then, sugammadex was administered in doses equimolar to rocuronium. The recovery index, time to T1 height > 95% of control, and the time to a TOF ratio > 0.9 after sugammadex administration were measured. RESULTS: The EC50, EC90, and EC95 of rocuronium fell significantly as the magnesium level increased. The EC50, EC90, and EC95 of rocuronium did not differ between the 3 and 4 mM groups. The recovery index, time to T1 height > 95% of control, and time to a TOF ratio > 0.9 after sugammadex administration did not differ among the four groups. CONCLUSIONS: Increases in the magnesium concentration in rat PNHD preparations proportionally enhanced the NMB induced by rocuronium but did not affect reversal by equimolar amounts of sugammadex.
Anesthesia ; Animals ; Magnesium Sulfate* ; Magnesium* ; Neuromuscular Blockade ; Phrenic Nerve* ; Rats*

OBJECTIVE: To determine the effect of magnesium sulfate (MgSO4) on the apoptosis and invasion of cytotrophoblasts in vitro under normal and hypoxic condition as assessed immunoblot analyses of Bcl-2/Bax, invasion assay and immunohistochemical staining of integrin alpha1. METHODS: Normal cytotrophoblasts were isolated from second trimester placentas and cultured in several physiologically relevant concentrations of MgSO4 under control tissue culture condition (20% O2) or hypoxic condition (1-2% O2). Apoptosis of cytotrophoblasts was estimated by immunoblotting for Bcl-2/Bax, invasiveness was estimated by invasion assay and immunohistochemical staining of Integrin alpha1. RESULTS: The expression of Bcl-2 did not change under standard condition, but it decreased under hypoxic condition with increasing of MgSO4 concentrations. The expression of Bax did not change under both standard condition and hypoxic condition with increasing MgSO4 concentrations. The invasiveness of cytotrophoblasts significantly decreased under both control and hypoxic conditions with increasing of MgSO4 concentrations. The expression of Integrin alpha1 immumohistochemical staining significantly decreased under control condition and showed decreasing tendency under hypoxic condition with increasing of MgSO4 concentrations. CONCLUSION: MgSO4 might induce cytotrophoblasts to the apoptosis and inhibit invasion of cytotrophoblasts under hypoxic condition.
Apoptosis* ; Female ; Humans ; Immunoblotting ; Integrin alpha1 ; Magnesium Sulfate* ; Magnesium* ; Placenta ; Pregnancy ; Pregnancy Trimester, Second ; Trophoblasts*

BACKGROUND: Magnesium sulfate(MgSO4) has long been used in the treatment of pre-eclampsia and hypertension. Mivacurium was found to undergo hydrolysis by plasma cholinesterase at 70-88% of the rate of succinylcholine. This study has been conducted to evaluate the time course of mivacurium-induced neuromuscular block according to the pretreatment doses of MgSO4 in rabbits. METHODS: This study was done using a common peroneal nerve-anterior tibialis muscle preparation in sixty adult rabbits. The onset and recovery times of mivacurium(0.16 mg/kg) were evaluated after the infusion of a placebo in group 1, MgSO4 30 mg/kg in group 2, MgSO4 50 mg/kg in group 3 and MgSO4 70 mg/kg in group 4, respectively(n=15 each). RESULTS: The mean serum concentration of magnesium was 2.4 mEq/L in group 1, 3.3 mEq/L in group 2, 4.3 mEq/L in group 3 and 5.5 mEq/L in group 4, respectively. The mean time from injection of mivacurium to 95% recovery of twitch amplitude was 32.7 min. in group 1, 32.9 min. in group 2, 30.4 min. in group 3 and 33.0 min. in group 4, respectively. CONCLUSIONS: The results of the present study suggested that the neuromuscular blocking actions of mivacurium are not affected according to the pretreatment doses of MgSO4.
Adult ; Cholinesterases ; Humans ; Hydrolysis ; Hypertension ; Ions ; Magnesium Sulfate* ; Magnesium* ; Neuromuscular Blockade* ; Plasma ; Pre-Eclampsia ; Rabbits* ; Succinylcholine

BACKGROUND: Magnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (NMB) during consistent pretreatment of MgSO₄ in rabbits. METHODS: Twenty-eight rabbits were randomly assigned to four groups, a control group or study groups (50% MgSO₄ 150–200 mg/kg and 25 mg/kg/h IV), and received rocuronium 0.6 mg/kg. When post-tetanic count 1–2 appeared, sugammadex 2, 4, and 8 mg/kg was administered in the 2-mg group, control and 4-mg group, and 8-mg group, respectively. The recovery course after reversal of sugammadex administration was evaluated in each group. RESULTS: The mean serum concentration of magnesium was maintained at more than 2 mmol/L in the study groups, and the total dose of MgSO₄ was more than 590 mg. The reversal effect of sugammadex on rocuronium-induced NMB in pretreated MgSO₄ was not different from that in the group without MgSO₄. The recovery time to train-of-four ratio 0.9 after sugammadex administration in the 2-mg group was longer than in the other groups (P < 0.001); there were no other significant differences among the groups. CONCLUSIONS: The reversal of sugammadex from a deep rocuronium-induced NMB during large pretreatment of MgSO₄ was not affected. However, we should consider that the reversal effect of sugammadex varied depending on the dose.
Arrhythmias, Cardiac ; Control Groups ; Hypertension ; Magnesium Sulfate* ; Magnesium* ; Neuromuscular Blockade* ; Pre-Eclampsia ; Rabbits*

BACKGROUND: Magnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (NMB) during consistent pretreatment of MgSO₄ in rabbits. METHODS: Twenty-eight rabbits were randomly assigned to four groups, a control group or study groups (50% MgSO₄ 150–200 mg/kg and 25 mg/kg/h IV), and received rocuronium 0.6 mg/kg. When post-tetanic count 1–2 appeared, sugammadex 2, 4, and 8 mg/kg was administered in the 2-mg group, control and 4-mg group, and 8-mg group, respectively. The recovery course after reversal of sugammadex administration was evaluated in each group. RESULTS: The mean serum concentration of magnesium was maintained at more than 2 mmol/L in the study groups, and the total dose of MgSO₄ was more than 590 mg. The reversal effect of sugammadex on rocuronium-induced NMB in pretreated MgSO₄ was not different from that in the group without MgSO₄. The recovery time to train-of-four ratio 0.9 after sugammadex administration in the 2-mg group was longer than in the other groups (P < 0.001); there were no other significant differences among the groups. CONCLUSIONS: The reversal of sugammadex from a deep rocuronium-induced NMB during large pretreatment of MgSO₄ was not affected. However, we should consider that the reversal effect of sugammadex varied depending on the dose.
Arrhythmias, Cardiac ; Control Groups ; Hypertension ; Magnesium Sulfate* ; Magnesium* ; Neuromuscular Blockade* ; Pre-Eclampsia ; Rabbits*