1.Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity.
Chen YAN ; Qun LONG ; Yun-Dong ZHANG ; Gajendran BABU ; Madhu Varier KRISHNAPRIYA ; Jian-Fei QIU ; Jing-Rui SONG ; Qing RAO ; Ping YI ; Mao SUN ; Yan-Mei LI
Chinese Journal of Natural Medicines (English Ed.) 2021;19(7):528-535
In this study, three new germacranolide sesquiterpenes (1-3), together with six related known analogues (4-9) were isolated from the whole plant of Carpesium cernuum. Their structures were established by a combination of extensive NMR spectroscopic analysis, HR-ESIMS data, and ECD calculations. The anti-leukemia activities of all compounds towards three cell lines (HEL, KG-1a, and K562) were evaluated in vitro. Compounds 1-3 exhibited moderate cytotoxicity with IC
Antineoplastic Agents, Phytogenic/pharmacology*
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Asteraceae/chemistry*
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Drug Screening Assays, Antitumor
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Humans
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K562 Cells
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Phytochemicals/pharmacology*
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Sesquiterpenes, Germacrane/pharmacology*
Result Analysis
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