1.Unmasking tumors: A case of a CD30-Negative MycosisFungoides masquerading as Erythema NodosumLeprosumin a filipino male.
Ma. Cristina Georgina T. Paloma ; Andrea Marie Bernales-Mendoza
Journal of the Philippine Medical Association 2023;101(2):29-32
Mycosis Fungoides is the most common type of primary
cutaneous lymphoma. Early in its course, it usually
presents as erythematous patches and plaques similar
to a lot of cutaneous conditions. A 68-year-old male
presented with a 13-year history of multiple
erythematous patches and plaques on the arms and
trunk. The lesions were pruritic and chronically relapsing
over the years, temporarily relieved by topical
corticosteroids. Thereafter, there was onset of multiple
nodules on the trunk, extremities and face. Initial biopsy
was done by a different dermatologist, revealed
Hansen’s Disease, Borderline Borderline spectrum.
Fitefaraco stain was positive but no bacillary index was
given. The patient was subsequently started on
rifamcpicin 600mg/capsule once a day, Ofloxacin
400mg/tablet once a day, and Minocycline
100mg/capsule once a day. The lesions were noted to
worsen, eventually developing ulcerations over the trunk
and extremities prompting referral to our institution. The
biopsy results were as follows: Cutaneous T-Cell
Lymphoma, diffuse cluster of differentiation (CD) 3
staining, focal CD20 staining, and negative FiteFaraco
stain. The histopathologic findings combined with the
clinical presentation led to the diagnosis of Mycosis
Fungoides. He was then referred to medical oncology
for proper staging and definitive management. The
prognosisof Mycosis Fungoides is generally dependent
on the stage as determined by the extent of skin
involvement as well as presence of lymph node invasion
and/or metastasis.
Mycosis Fungoides
;
Lymphoma
;
T-Cell
;
Cutaneous