PURPOSE: We carried out to determine the effectiveness of trabeculectomy and neodymium:YAG (Nd: YAG) cyclophotocoagulation in eyes with neovascular glaucoma from diabetic retinopathy. METHODS: We retrospectively reviewed medical records of patients who had undergone trabeculectomy or Nd:YAG cyclophotocoagulation from May 1992 to August 1997. RESULTS: The average drop in IOP was 24.6 mmHg in the trabeculectomy group and 17.3 mmHg in the transscleral cyclophotocoagulation group. Success rate was 69.2% in the trabeculectomy group and 21.4% in the transscleral cyclophotocoagulation group. Most common postoperative complication was hyphema (38.4%) in the trabeculectomy group and phthisis bulbi (21.4%) in the transscleral cyclophotocoagulation group. CONCLUSIONS: Trabeculectomy had higher success rate and less serious complications than transscleral cyclophotocoagulation. Transcleral cyclophotocoagulation may be considered as a treatment of neovascular glaucoma in the patients who have severe pain or poor general condition.
Diabetic Retinopathy* ; Glaucoma, Neovascular* ; Humans ; Hyphema ; Medical Records ; Postoperative Complications ; Retrospective Studies ; Trabeculectomy*

OBJECTIVECheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction () and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms.

METHODSIn this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6), prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and β-hexosaminidase (β-hex).

RESULTSOur data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and β-hex induced by PMA plus A23187 (P<0.05).

CONCLUSIONThese findings indicate that CITE has the potential for use in the treatment of allergy.

Animals ; Anti-Inflammatory Agents ; pharmacology ; therapeutic use ; Bone Marrow Cells ; pathology ; Calcimycin ; pharmacology ; Cell Degranulation ; drug effects ; Cell Survival ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Hypersensitivity ; drug therapy ; pathology ; Interleukin-6 ; secretion ; Leukotriene C4 ; pharmacology ; Male ; Mast Cells ; drug effects ; pathology ; physiology ; Mice ; Mice, Inbred BALB C ; Prostaglandin D2 ; biosynthesis ; Tetradecanoylphorbol Acetate ; pharmacology ; beta-N-Acetylhexosaminidases ; metabolism