Vasomotor symptoms(VMS)are among the typical manifestations in perimenopausal and menopausal women, with a high incidence and prolonged duration, and have long been afflicting many menopausal women.Cardiovascular disease has become one of the main causes of death in postmenopausal women.Previous studies suggest that postmenopausal VMS are related to the occurrence of cardiovascular disease in postmenopausal women, but the view is controversial.There have been many studies on the association of VMS in menopausal women with the risk of cardiovascular disease, cardiovascular disease risk factors and subclinical indicators, and the results suggest that menopausal VMS may predict the occurrence of cardiovascular disease after menopause.

The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated.This retrospective study included data collected from 1051 patients from July 2011 to June 2014.Multiple maternal baseline covariates were subjected to propensity score matching analysis,and each day 5/6 group woman was matched to one day 2/3 group woman.A systematic meta-analysis was conducted to validate the results.After matching was completed,217 patients on the day 2/3 group were matched with those on the day 5/6 group,and no significant differences in the baseline characteristics were observed between the two groups.The cumulative pregnancy rate (57.14％ vs.53.46％,OR 1.16,95％ CI 0.79-1.70) and cumulative live birth rate (53.00％ vs.49.77％,OR 1.14,95％ CI 0.78-1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers,but this difference was not significant.The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group.This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.