No abstract available.
Hernia, Inguinal*

No abstract available.
Gastrectomy* ; Humans ; Quality of Life* ; Stomach Neoplasms*

Testicular feminization syndrome (TFS) is a genetic disorder due to androgen insensitivity of the target organs. The most common clinical presentation of complete TFS is inguinal hernia in the infant or primary amenorrhea in the adolescence. A 7-year old phenotypically female patient was seen with a complaint of a right inguinal mass. Under the diagnosis of right inguinal hernia, high ligation was performed. Six months later, the patient showed a left inguinal mass. On operation, the mass looked like a testis. The external genitalia were normal female, but a uterus and ovary were not identified. Chromosome study showed a 46, XY karyotype and the levels of serum testosterone and dihydrotestosterone were increased after HCG stimulation. The patient was diagnosed as complete TFS and underwent bilateral gonadectomy 6 months later.
Adolescent ; Amenorrhea ; Androgen-Insensitivity Syndrome* ; Child ; Diagnosis ; Dihydrotestosterone ; Female ; Genitalia ; Hernia, Inguinal ; Humans ; Infant ; Karyotype ; Ligation ; Male ; Ovary ; Testis ; Testosterone ; Uterus

Testicular feminization syndrome (TFS) is a genetic disorder due to androgen insensitivity of the target organs. The most common clinical presentation of complete TFS is inguinal hernia in the infant or primary amenorrhea in the adolescence. A 7-year old phenotypically female patient was seen with a complaint of a right inguinal mass. Under the diagnosis of right inguinal hernia, high ligation was performed. Six months later, the patient showed a left inguinal mass. On operation, the mass looked like a testis. The external genitalia were normal female, but a uterus and ovary were not identified. Chromosome study showed a 46, XY karyotype and the levels of serum testosterone and dihydrotestosterone were increased after HCG stimulation. The patient was diagnosed as complete TFS and underwent bilateral gonadectomy 6 months later.
Adolescent ; Amenorrhea ; Androgen-Insensitivity Syndrome* ; Child ; Diagnosis ; Dihydrotestosterone ; Female ; Genitalia ; Hernia, Inguinal ; Humans ; Infant ; Karyotype ; Ligation ; Male ; Ovary ; Testis ; Testosterone ; Uterus

No abstract available.
Child* ; Humans ; Lymphangioma*

No abstract available.
Child* ; Humans

No abstract available.
Thyroid Gland* ; Thyroid Nodule*

No abstract available.
Humans

Despite of advances in perinatal management and treatment modalities, congenital diaphragmatic hernia (CDH) remains a frustrating problem. Although the sheep has been the most reliable experimental animal of fetal surgery in CDH, the rabbits has some possible advantages over sheep; lower cost, smaller body size, year-round availability, high number of fetuses per pregnancy, and short gestational period. The purpose of this study is to evaluate the feasibility of the animal model of CDH in rabbits. Twenty seven pregnant New Zealand rabbits underwent hysterotomy and fetal operation on gestational day 24 or 25. Two fetuses of each pregnant rabbit were operated. In the fetus of one end of bicornuate uterus, left diaphragmatic hernia was created by excision of fetal diaphragm through open thoracotomy (DH Group). In the fetus of the other end of bicornuate uterus, left diaphragmatic hernia was created and tracheal ligation by small-sized Surgiclip(R) (USSC, Norwalk, Conn., USA) was performed through cervical incision (TL Group). Among twenty seven pregnant rabbits, twelve were born alive with diaphragmatic hernia and eight were born alive with diaphragmatic hernia & tracheal ligation. The most commonly herniated abdominal organ was the left lobe of liver. In DH group, the lungs were hypoplastic with a decrease in lung weight/body weight ratio, a reduction in number of alveoli, an increase of vascular medial wall thickness of pulmonary arteries. The alveoli were immature with thick alveolar septum and increased interstitium. In TL group, the alveoli were more mature than that of DH group and no significant difference from control group was existed. Thus this study demonstrates that (1)Diaphragmatic hernia can be created in rabbits by fetal surgery, (2)Tracheal ligation can be performed in rabbits by fetal surgery, (3)Experimental diaphragmatic hernia results in pulmonary hypoplasia, (4)Concurrent tracheal ligation prevents pulmonary hypoplasia that resulted from diaphragmatic hernia. The above mentioned results show that pregnant New Zealand rabbit is appropriate as the animal model of CDH.
Animals ; Body Size ; Diaphragm ; Fetus ; Hernia ; Hernia, Diaphragmatic* ; Hysterotomy ; Ligation* ; Liver ; Lung ; Models, Animal ; Pregnancy ; Pulmonary Artery ; Rabbits ; Sheep ; Thoracotomy ; Uterus

No abstract available.
Child* ; Hernia, Diaphragmatic* ; Humans