It became clear from our latest research that the module- hierarchical principle is followed to compound the multi - ingredient drugs in traditional medicine. This time we have compared some pharmacological actions of the drugs: Gurgem-3, hepatic Gurgem-7, large in­testine Gurgem-7. Model index of drugs ability to reduce khii, shar, badgan was estimated by count method. Study was done on mice and rats using some general,special and elective pharmacological methods. Unnatural pathology such as hyperthermia, diarrhea, enterocolitis was conceived on animals afterwards recipe's action was studied . According to the research all these three drugs reduce fever, relieve pain and have actions against inflammation. But comparing the hepatic Gurgem-7 with the other drugs, it has tendency to precipitate the coagulation and in­crease the bilirubin, cholesterin and the bile acid secretion. Intestine Gurgem-7 has a tendency to prevent from and treat the gastrointestinal activity disorder more than oth­ers. Preconceptional investigation showed that the module - hierarchical principle of the compounding traditional drugs is proved to be a new scientifically well-founded method.

In Mongolia has described four species of Lonicera Altaica (Caprifoliaceae). Their habitats are Khubsugul, Khangai Khentei, Khobdo, Mongolian Altai, and Depression of Great Lakes, Mongol Daguur and the Gobi-Altai (Three beauty of Gobi) region of the country. The Tibetan medicine named berry Phan-ma'i bra'i bu (Lonicera Altaica) was used for vitality and energy supplier. In some medical texts, the berry was described to be used for longevity. Lonicera Altaica in Mongolian Traditional medicine is reputed for its treating liver, stomach and cardiac disorders, moreover, it is known for rejuvenation action. The Lonicera Altaica Lonicera altaica is found to be abundant among all other species. It s a black blue color ber­ries, with bitter taste. In Lonicera Altaica Pall was determined that ash no more than 5%, moisture 5% and organic and mineral ingredi­ent 0.5%. The quantity of flavonoid of fruits, seeds on Lonicera Altaica Pall was 5.598% by a method of spectrophotometry.

Artemisa Sphaerocephala Krasch, grown in the territory of Mongolia has confi rmed to possess considerable amount of Polysaccharide. This secret revelation of high molecule content of polysaccharide is regarded as a new discovery in natural sciences. For the past years, scientist has been striving to fi nd antigen from polysaccharide of plants for antibody protection in order to eliminate immune defi ciency in the body. The aim of our work intends to defi ne the mechanism of effects of polysaccharide contained in one Gobi plant. The study was carried out on polysaccharide preparation for immunization of Artemisia Sphaerocephala Krasch. Study on the effect of the preparation on spleen and lymph nodes: The most effective period of Artemisia Sphaero­cephala Krasch preparation on the animals was observed by “Olympus” microscope by coloring with Methylgreen-Pyronin by the alternative method of revealing nucleic acid of Papanheum Unna., Cook. The actions against of anticomplementary activity of polysaccharide preparation from Artemisia Sphaerocephala Krasch: The polysaccharide preparation showing 76.59% effective in immunoreactions. Our series of investigation prove that the preparation. Membrane protection effect of polysaccharide preparation of the Artemisia Sphaerocephala Krasch: Polysaccha­ride preparation of Artemisia Sphaerocephala decreased of the accumulation on lipid per oxidation products and showed membrane protective and antioxidant effect. The preparation showed that increases the stability of cells membrane. Artemisia Sphaerocephala Krasch is immune stimulatory activity and increase body resistance is due to polysac­charides.

BACKGROUND: 70-80% of the world’s population uses herbal therapy and drug preparations of traditional medicine for health and first aid treatment [1]. SDS is used for relieving fever and also used as an anti-inflammatory medicine.1-2 It is also used in the treatment of cancer and infectious disease in Eastern and Chinese medicine. It is important to study the pharmacological actions and do a genome study in order to use natural resources wisely and to access biological effects on the plant. AIM: The study of the herbal preparation Saposhnikovia Divaricata on joint inflammation MATERIALS AND METHODS: All the experimental procedures and protocols used in the study were reviewed and approved by the Bio-Medical Ethical Committee of Mongolian National University of Mongolia. A dry extract of SDS is root was prepared by the lyophilization method and used in the study. CIA pathology model were determined by the David D Brand (2005) method. Statistical Analysis: Statistical analysis of data was performed by SPSS 16.0 program and analyzed statistically using criteria of Student t test. RESULTS: As a result the treatment group of mice with the use of the drug Saposhnikovia divaricata and groups of mice were treated with sodium salicylate, the body weight of mice increased significantly, and histological signs of inflammation were pronounced. In the mice of the control group who did not receive treatment, body weight decreased significantly, and histological signs of inflammation of the joints were expressed significantly. CONCLUSION: Preparation of Saposhnikovia divaricata decreased inflammation of arthritis.

BACKGROUND: A recent day is one of a rare drug plant, which use in traditional medicine a long time ago. Therefore based on nature resource of traditional medicine, on the base of evaluating pharmacological and biological action to develop a new drug of plant origin is important not only for treatment, but also has a economic significance. This plant has profound medicinal use and is a proved antipyretic, analgesic anti inflammatory and anti-cancer. No detail report was found in literature to evaluate renal damage experimentally in rats. The present study was hence designed to determine protective effect (Saposhnikovia divaricate (Turcz) Schischk) kanamycin-induced nephrotoxicy in rats. In addition, we attempted to test and compare the possible action of Saposhnikovia divaricate (Turcz) Schischk) kanamycin-induced nephrotoxicity in rats. MATERIALS AND METHODS: Experimental animals A dry extract of SDS is root was prepared by the lyophilization method and used in the study. Threemonth old Wistar albino rats of either sex weighing 150-250 g were used for the study. The animals were placed at random and allocated to treatment groups in polypropylene cages with paddy husk as bedding. Animals were housed at a temperature of 24 ± 2⁰C and relative humidity of 30-70%. A 12/12 h light and dark cycle was followed. All animals were fed on standard balanced diet and provided with water ad libitum. All the experimental procedures and protocols used in the study were reviewed and approved by the Bio-Medical Ethical Committee of Mongolian National University of Mongolia. Biochemical estimation At the end of experimental period, rats were anaesthetized with ether. The pathological model of kidney we use lipid peroxidation in the process of kidney inflammation kidney tissue, blood serum, erythrocyte MDA of membrane amount on 3, 7, 14 day by using spectrophotometer apparatus of “Shimadzu” firm of Japan and measured absorption at 535 nm. Statistical Analysis: Statistical analysis of data was performed by SPSS 16.0 program and analyzed statistically using criteria of Student t test. RESULTS: When we studied effect of extract of SDS preparation to condition of lipid peroxidation activation in the process of kidney inflammation by the indices of MDA which contains in blood plasma and erythrocyte membrane, MDA amount in renal tissue, amount of MDA decreased and it showed effect of decreasing lipid peroxidation MDA of plasma. CONCLUSION: The extract of Saposhnikoviadivaricata (Turcz) Schischk) has action of protecting kidney and decreasing lipid per oxidation.

INTRODUCTION: One of the main issues on the National drug policies in countries of the world and in Mongolia is the proper usage of the drug. In this frame, we need to study and to implement the methodical basis to use drug market drug marketing theoretical principles . They are: to improve and to follow new standard in diagnostics and diseases treatments prevailing in our country, to stop inappropriate usage of drugs, to implement the drug program of national necessity, to determine the drug usage in the proper way, and to organize the control properly. According to the statistic report of 2002 through 2008, the rate of skin disease was ranked as 8 (4.5%) among common diseases, and as 7th (4.07%) among aimag level, but on the other hand the skin disease rate has increased by 59213 cases compared between 2002 and 2008. GOAL AND OBJECTIVES: The main goal of the study was to determine the drug needs used in dermatological diseases where the results were compared with the current standard and to develop future recommendations to improve the proper usage of medicines. MATERIALS AND METHODS: In order to calculate the drug cost and demands, the main marketing methods were used such as calculation of past, current and future prognosis of drug demands. For example: ∎ The calculation of drug expenditure ∎ Calculation of drug demands by number of registered disease cases ∎ Development of the future prognosis of the disease based on the assessment of experts RESULTS: 1092 patients who were hospitalized in 2007 and 2008 in National Center of Dermatology, 464 patients who were hospitalized in the epidermis department of the general hospital of 12 provinces, totally 1725 patient’s medical histories were chosen for drug usage in this research work. Average, patient day 12,7, males 867(50,3%) females 858(49,7%) children 283 (16,4%), adults 1442 (83,6%) participated in the research work. From all patients who are hospitalized are: patients who are in the hospital for the first time 1090 (63,2%), patients hospitalized for the second time 635 (36,8%). About patients who discharged from the hospital: 1055(61,2%) patients were recovered, and 670 (38,8%) patient’s health conditions were improved. Here is the approved diagnosis in the frame of the research work: dermatitis 605 (35.1%), Psoriasis 355 (20,5%), eczema 266 (15.4%) is leading the list. DISCUSSION: According to research on the drug proper usage, each drug used for patients treatment was calculated upon the drug type, quantity, and patients percentage and it is concluded by its classification of analogical quantification. They are: Patient percentage who treated and recovered with preparations against Gistamin 62.8, Patient percentage who treated and recovered with antibiotics and preparations against bacterium 72.8, Patient percentage who treated and recovered with drugs of Corticosteroid group 87.4, Patient percentage who treated and recovered with viricide 16.9, Patient percentage who treated and recovered with antidote and sorbent 21, Patient percentage who treated and recovered with drugs promoting the body organs, organ system functions 81.7, Patient percentage who treated and recovered with Preparation for skin casting 51, Patient percentage who treated and recovered with disinfection preparations 45.

INTRODUCTION: Main reasons of metabolic syndrome are obesity and overweighing, which are becoming a global worldwide problem. Obesity is both a prevalent condition worldwide and a well-known, modifiable risk factor for various diseases, including diabetes. In a recent review article, waist circumference (WC) and body mass index (BMI) were reported as established risk factors for diabetes. GOAL: To define the prevalence of metabolic syndrome among Mongolian aging man living in Ulaanbaatar city MATERIALS AND METHODS: Randomly selected 180 men aged 35-90 years old were involved to this study. All were informed and written consent was given by each individual. The metabolic syndrome was defined by NCEP definition: high blood pressure, high waist circumference, higher fasting sugar, triglyceride and HDL-cholesterol. Anthropometric parameters like waist circumference (WC), weight, height, blood pressure and blood chemical parameters like glucose, triglyceride (TG), HDL-cholesterol (HDL-Ch) were measured by automatic biochemical analyzer. RESULT AND DISCUSSION: Average age of all participants was 56.82±12.55 years and was divided in three age groups: 35-60 (n=112), 61-74 (n=47), 74-90 (n=17). The characteristics of participants are shown Mongolian men in 38.8 % (70) of all participants had a metabolic syndrome and in compare to T.Baysgalan’s study, implemented in 2007 was higher. In our opinion it depends on our study participant’s age, because in our study number of elderly were predominating than mentioned survey. Waist circumference in metabolic syndrome group is higher than in healthy control group (p<0.05). Triglyceride level does not change with aging, but in our study participants, the TG level was negatively correlated with aging in metabolic syndrome group (r = -0.307). HDL-cholesterol is abundantly circulating molecule in human plasma and shows anti-atherogenic effect. In our participants HDL-Ch decreases with aging (r=-0.174). CONCLUSION: Our pilot study present that metabolic syndrome prevalence reaches 38.8% of total aged, male participants, and it is leads to implement and provide an investigation in large range, including urban and rural areas of the country.

INTRODUCTION: There have been limited research studies done in Mongolia on clinical, laboratorial and computer tomographical diagnosis of acute pancreatitis. GOAL: Our study aims to examine clinical, laboratorial and CT symptoms diagnosis of acute pancreatitis, to diagnose the different types of acute pancreatitis, and to develop diagnostic criteria based on CT for differentiating among those types. OBJECTIVES: 1. To study clinical symptoms of acute pancreatitis 2. To determine alpha amylase, ALAT, ASAT, and the amount of glucose. 3. To determine CT symptoms for the types of acute pancreatitis. 4. To develop diagnostic criteria based on CT for differentiating among those types MATERIALS AND METHODS: Over the years of 2006 to 2010, we have studied the CT symptoms of 59 patients diagnosed as having acute pancreatitis, and the clinical and laboratorial symptoms of 81 patients with the same disease, with the help of health facilities at Diagnostic Imaging Department of the “Achtan-elite” general hospital and “Friendship-Naran” diagnostics center. The scanners such as CT-W-4 type scanner of Japanese Toshiba Corporation, MSCT Presto (made in 2007 by Hitachi, Japan) and CT Max 640 type scanner of USA General Electric Corporation have been used for the diagnostics. We successfully calculated the amount of alpha amylase, ALAT, and ASAT with colorimetric analysis. For this calculation, we used amylase detector manufactured by German Human Firm. Sugar amount was measure by fermentive oxidization with dioxide-glucose. The acute pancreatitis inflammation, hemorrhage, necrosis and its various forms, and diagnosis have been proved by the brief x-ray imaging of the abdomen, x-ray with contrast injections for stomach and upper intestine, Ultrasonic, Celliacography, MRI, Cytology, Biopsy analysis and surgery. All the results were presented in commonly used statistical ways, taking into account possible calculation errors, and probabilities were checked with Student’s t-distribution. CONCLUSION: 1. During acute pancreatitis, 56.8%±5.5 suffered from abdominal shooting pain, 28.3%±5.0 from stomach cramps, 79.0%±4.5 from diarrhea, 91.4%±3.1 from fever, and 56.8%±5.5 from abdominal hemorrhage. 2. The amount of alpha amylase in blood serum increased 6 times the amount of ASAT/ALAT 3 to 5 times. 3. By CT scanning, we have found more common CT symptoms such as sharp border edges of pancreas in swollen acute pancreatitis (in 69.2%±9.2 of the patients), entire and partial enlargement of the pancreas (in 73.1%±8.9 of the patients), fluid collection in the stomach rear room (in 61.1%±11.8 of the patients), in hemorrhage acute pancreatitis and uneven density reduction (in 66.7%±12.6 of the patients) and fluid collection in the stomach rear room (in 86.7%±9.1 of the patients), in necrosis type of acute pancreatitis respectively. 4. Shape, size, structure, density, borders, interaction with surrounding body organs, change in pancreas density after contrast injection and accumulated fluid in the rear stomach are identified as the main criteria to diagnose acute pancreatitis types and differentiate among them. 5. CT diagnostics of the acute pancreatitis types and differentiating among them are very crucial to select appropriate acute pancreatitis treatment on time.

INTRODUCTION: Excessive use of salt lead to development of noncommunicable diseases, especially to hypertension [1, 2, 3, 4, 5].The WHO Global Action Plan for the Prevention and Control of NCDs 2013-2020 (Geneva, 2012) called for a reduction of population salt intake by 30 percent by 2025 [13, 14, 15, 15, 16, 17]. There was no any data on salt content collected under the fourth National Survey on Nutrition 2010 and the STEPS survey on the prevalence of noncommunicable disease risk factors 2005, 2009 and 2013. Thus, this is first time ever, the detailed data on salt content was collected and analysed. MATERIALS AND METHODS: Fifty two food production and food handling organizations were enrolled during 2011-2012 through crosssectional survey. In total, 251 samples from 43 types of meals were tested NaCI ion by titer method in the laboratory of National Center of Public Health and statistical analysis were done by running SPSS package, Version 19. The ethical approval has been obtained from the Ethics Committee of the Ministry of Health in 2011 (Resolution No. 14). RESULTS: An average content of salt was 0.94 g/100 g (SD 0.42, 95%CI 0.90-1.00) in the commonly used meals from mass catering services. For example, soup has content of 0.86 g/100 ml (SD 0.23, 95%CI 0.81-0.91) of salt; fried meal has 1.03 g (SD 0.41, 95% CI 0.95-1.12); buuz – meat dumpling, khuushuur- fried meat dumpling, buns, pirojki –russian fried dumpling, fried sausage, hot dog, hamburger, pizza and other fast food -1.12 g/100 g (SD 0.34, 95%CI 0.93-1.14); vegetable salad and meat snacks 0.90 g/100 g (SD 0.62, 95%CI 0.77-1.18); tea -0.69 g/100 ml (SD 0.50, 95%CI 0.49-0.92) of salt. CONCLUSIONS: Eighty five percent of Mongolian commonly consumed food were classified as ”high salt” content. Mongolian meal recipes for mass catering services that 1 portion of meal contains 1 g salt. The study results will serve as an evidence-based recommendations to further revision of the current recipes. Thus, it is important to renew a salt content in 100 g of foods based on international recommendations.

JUSTIFICATION: According to the World Health Organization (WHO), 6.6 million children under the age of five died in 2012 - more than 750 every hour. Most of these children could survive and thrive with access to simple, affordable interventions. The loss of a child is a tragedy - families suffer and human potential is wasted. WHO is improving child health by helping countries deliver integrated, effective care in a continuum, starting with a healthy pregnancy for the mother, through birth and care up to five years of age. Investing in health systems is important to delivering this essential care [1, 2]. GOAL: To study perinatal mortality, this is the most important reason of infant mortality in Mongolia. MATERIALS AND METHODS: A retrospective cohort study was conducted reviewing data from 2007-2011 using the ICD code P00-P96 [4] listing “certain conditions originating in the perinatal period”. Data was analyzed using Epi-Info 2000 and GIS software. RESULTS: Data from 2007-2011 showed that 3091 neonates died from conditions originating in the perinatal period and of these 58.7% (1814) were males. Furthermore, the results of this study showed that the leading causes of death were “respiratory and cardiovascular disorders during the perinatal period” (ICD code P20-P29). More specifically, the causes were: - Birth asphyxia (P21) - Respiratory distress of newborn (P22) - Congenital pneumonia (P23) CONCLUSION: National average deaths per 1,000 live births in Mongolia are 9.5—with the highest rates reported in Dornogovi, Uvurkhangai, Bayankhongor, Gobi Altai, Uvs, Zavkhan and Khovsgol.