OBJECTIVE:To evaluate the efficacy of esomeprazole vs.lansoprazole in the treatment of patients with reflux esophagitis (RE).METHODS:A total of 120 patients with RE were randomly assigned to receive either esomeprazole (20 mg n&m,treatment group) or lansoprazole (30 mg n&m,control group) for 8 weeks.The symptomatic scores including heartburn,retrosternal pain and acid regurgitation,and gastroscopic curative efficacy at 4 and 8 weeks were obtained for the evaluation of clinical efficacy.RESULTS:In the treatment group at 4 and 8 weeks after treatment,the total effective rates in improvement of clinical symptoms were 78.1% and 87.5%,respectively,and the total effective rates of gastroscopic curative efficacy were 87.5% and 93.8%,respectively;while in the control group at 4 and 8 weeks,the total effective rates in improvement of clinical symptoms were 60.7% and 73.2%,respectively,and the total effective rates in gastroscopic curative efficacy were 73.2% and 80.4%,respectively,showing statistical differences in total effective rates between esomeprazole and lansoprazole(P

Objective:To investigate the clinicopathological significance of the CyclinB1 and CDK1 expression in stomach carcinogenesis.Methods:The expression of CyclinB1 and CDK1 was examined by immunohistochemistry method in normal epithelium(15 cases),low-differentiated adenocarcinoma (15 cases)and moderate-well-differentiated adenocarcinoma (20 cases).Results:Immunoreaction to Cyclin B1 and CDK1 was mainly localized in the cytoplasm of cells.In stomach carcinogenesis,the positive immunostaining rate of CyclinB1 protein in normal epithelium and adenocarcinoma was 13.3%(2/15),94.3%(33/35) respectively (P

OBJECTIVE:To study the species and drug resistance of the bacteria isolated from sputum specimens of the inpatients in our hospital.METHODS:The drug susceptibility of 2 255 strains of pathogenic bacteria cultured from 6 052 qualified sputum specimens that collected from inpatients of our hospital between Jan.2005 and July 2007 were analyzed retrospectively.RESULTS:Of the 2 255 strains of pathogenic bacteria,1 210(53.7%)were gram negative bacillus,with Pseudomonas aeruginesa,Escherichia cob,Klebsiella pneumoniae and Acinetobacter showing the highest proportion,accounting for 19.5%,13.9%,8.2% and 6.4%,respectively;429(19.0%)were gram positive coccus,with CN-S and Staphylococcus aureus showing the highest proportion;and the 519(23.0%)were fungus with Candida albicans showing the highest proportion.CON-CLUSION:The result of drug susceptibility test showed that both gram negative bacilli and gram positive coccus were highly resistant to quite a few of antibiotics.

Neuroblastoma(NB)is the most common extra -cranial malignant tumor of children.While it ac-counts for 7% of all childhood malignancies,NB accounts for 1 0% of childhood cancer mortality.According to the risk group classification systems,there is high heterogeneity malignant degree of NB.Many bio -features are associated with the prognosis of NB.As the development of the diagnosis and therapy,the relationship between some bio -features and the prognosis has been changed.In the future,target therapy of molecular biology may be a new breakthrough in the therapy area.

During the treatment of pediatric tumor,vincristine is one of the most widely used and most effective drugs. However,the adverse reactions have limited its clinical application. In recent years,studies have found that the metabolism of vincristine are different in different races and different individuals,and co-ad-ministration with certain drugs such as imidazoles antifungal drugs may enhance its adverse reaction. Resear-ches on new drug delivery system provide a new idea for reducing the adverse reactions of vincristine and impro-ving its bioavailability.

This paper reported all kinds of assay of soybean isoflavone on the basis of collecting and analyzing relating literatures at home and abroad. The assay conditions were listed and compared in this paper. The authors believed that the assay should be selected according to the circumstances.

OBJECTIVE: To provide reference for the reduction of dispensing error rate and the hidden dispensing danger in outpatient pharmacy.METHODS: The drugs with similar outer package in the outpatient pharmacy of a hospital in 2007 were investigated and knew the hidden drug dispensing danger caused by similar outer package by the staff mambers in the outpatient pharmacy.RESULTS: A total of 7 pairs of drugs were found to be of similar outer package in pattern,color or the size of package etc,which resulted in hidden dispensing errors in 39 cases.CONCLUSIONS: Great importance should be attached to the drugs with similar outer packages and countermeasures should be taken to avoid the hidden dispensing errors induced by it.

Objective: To study and discuss the experience veteran TCM doctor KONG Si-bo in treating optical disease. Methods: To analyze the academic thoughts of KONG Si-Bo from four aspects: theory, method, formula and herbs. Results: According to differentiation of syndrome, KONG Si-bo emphasized on the entirety and treating according to three categories of disease causes. He thought that on the base of traditional eight principle differentiation, yin and yang played a more important role in differentiation. In treatment aspect, he prefered to eliminating stagnation, especially eliminating liver stagnation. As for herbs, he liked using Shigao to clear heat, and had lots of gains from learning about herbs of expelling wind, regulating qi, dissipating stasis, invigoration. Conclusions: The experience of expert KONG Si-bo in treating optical disease deserved researching and learning by other doctors.

Objective To discuss the clinical features and coronary artery lesions in middle-aged and young patients of coronary heart disease complicated with diabetes mellitus. Methods The clinical data of 386 middle-aged and young patients (aged from 28 to 59 years) of coronary heart disease were retrospectively analyzed. Among them, 176 cases were complicated with diabetes mellitus (diabetes group) and 210 cases didn′t have diabetes mellitus (non diabetes group). The general information, echocardiography and coronary angiography results between 2 groups were compared. Results The female ratio, incidences of hypertension and body mass index (BMI) in diabetes group were significantly higher than those in non diabetes group:28.4%(50/176) vs. 6.7%(14/210), 63.6%(112/176) vs. 43.8%(92/210) and (26.5 ± 2.5) kg/m2 vs. (23.8 ± 1.7) kg/m2, and there were statistical differences (P<0.01). There were no statistical differences in the age and the incidences of smoking history, family history of coronary heart disease and heart failure between 2 groups (P>0.05). The total cholesterol (TC) and triglyceride (TG) in diabetes group were significantly higher than those in non diabetes group:(4.96 ± 1.32) mmol/L vs. (4.67 ± 1.12) mmol/L and (2.77 ± 2.01) mmol/L vs. (2.09 ± 1.60) mmol/L, the high-density lipoprotein cholesterol (HDL-C) was significantly lower than that in non diabetes group:(0.92 ± 0.30) mmol/L vs. (1.10 ± 0.32) mmol/L, and there were statistical differences (P<0.01). There were statistical differences in the hemoglobin, platelet, total bilirubin, brain natriuretic peptide, fibrinogen (FIB) and low-density lipoprotein cholesterol (LDL-C) between 2 groups (P>0.05). There were no significant differences in the left atrial diameter, right ventricular diameter, left ventricular end diastolic diameter, ejection fraction, aortic root inside diameter and incidence of weakened ventricular wall motion between 2 groups (P>0.05). The incidence of 3 branch coronary artery lesions in diabetes group was significantly higher than that in non diabetes group:59.1%(104/176) vs. 37.6%(79/210), and there was statistical difference (P<0.01). The incidences of left main artery, circumflex artery trunk, diffuse vascular lesion and Gensini score in diabetes group were significantly higher than those in non diabetes group: 15.9% (28/176) vs. 6.2% (13/210), 79.5% (140/176) vs. 53.8% (113/210), 46.5%(82/176) vs. 23.8%(50/210) and (58.6 ± 17.9) scores vs. (49.5 ± 14.6) scores, and there were statistical differences (P<0.01). There were no statistical differences in incidences of anterior descending artery and right coronary artery between 2 groups (P>0.05). Conclusions In middle-aged and young patients of coronary heart disease complicated with diabetes mellitus, the female ratio is higher and hypertension, obesity and hyperlipidemia is more common. The lesions of coronary artery are more serious and diffuse. Three branch coronary artery lesions are the main ones, and the left main branch and the circumflex branch lesion is common.

In recent years,more and more Macrolide resistance of Mycoplasma pneumoniae becomes a hot research.The current studies suggest that the mechanisms of Macrolide resistance are drug-binding site mutations,ribosome methylation,drug efflux,and drug related fire-fighting,in which the drug target 23srRNA gene 2063,2064 mutation is significant.It has been reported that drug-resistant patients have the poor effect,including the long total febrile days and high dressing.For treatment of drug-resistant patients,most studies still use the macrolide,early use of corticosteroids may be effective.It is uncertain whether the increase in resistant strains is related with the use of macrolide.It is significant to carry out future researches in this area for clinical therapy and put off the prevalence of drug-resistant strains.