Studying fibroblast isolated from normal gingival and overgrowth gingival to synthesize and refine recombination HIP on organ transplant patients, who were treated by cyclosporine A inhibitor, showed that recombinant human HIP in E. coli was refined with high clean level. HIP helps to inhibit the growth of fibroblast isolated from overgrowth gingival, antagonize with bFGF-induced proliferation. The study is shedding light on using HIP and HSPG in treatment of overgrowth gingival, a side effect of CsA and derivatives, to prevent patients from periodic gingival remove
Fibroblasts ; Gingiva