1.Functional Outcome of Isolated Hoffa Fractures Treated with Cannulated Cancellous Screw
Singh R, Ms ; Singh Rb, Ms ; Mahendra M, Dnb
Malaysian Orthopaedic Journal 2017;11(2):20-24
Introduction: Isolated Hoffa fracture is an infrequent injury
and little research has been done on this subject. The purpose
of this study was to evaluate the functional outcome and
complications of surgically managed Hoffa fractures with
cannulated cancellous screw.
Materials and Methods: Between 2011 and 2014, eight
isolated Hoffa fractures in seven adult patients with mean
age 39.8±11.9 years (range 25-60 years) were managed with
cannulated cancellous screw of 6.5mm diameter applied in
anterior to posterior direction using swashbuckler and medial
parapatellar approach for lateral and medial Hoffa fractures
respectively. All patients were evaluated using knee
evaluation score after two years or longer. Mean follow up
was 28±3.8 months (range 24-36 months).
Results: All fractures in the eight patients healed clinicoradiologically
by the 16th week with excellent result in
87.5% cases and good in 12.5% cases. By the end of union,
the range of motion (ROM) of the knee was 0° to 110° except
in two patients. One patient had ROM 10°-100° and other
had 15°-90°. Mean knee evaluation score was 87.5±10.4.
There was no incidence of non-union, infection or avascular
changes in the patients or loss of reduction till final follow
up.
Conclusion: Open reduction and fixation with two 6.5 mm
cannulated cancellous screws with early mobilization
yielded good functional outcome in isolated Hoffa fractures.
3.Pain characteristics in Parkinson’s disease: An Indian experience
Birinder Singh Paul M ; Gunchan Paul ; Gagandeep Singh ; Sandeep Kaushal ; Amarinder Dhaliwal ; Inder Dev Bahia
Neurology Asia 2014;19(2):157-162
Background & Objective: Parkinson’s disease (PD) is a chronic neurological disease, many a times presenting with non-motor symptoms. Pain is one of the most important non-motor symptom and there is no consensus regarding its exact mechanism and characterisation. This study was planned to evaluate the characteristics of pain and possible factors influencing it, in a cohort of patients with established Parkinson’s disease. Methods: 104 patients consenting to participate were included in the study. Data regarding age of onset, duration of disease, treatment, Hoehn-Yahr scale, phenotype of PD, UPDRS scores, pain type and distribution of pain were noted. Single and multiple logistical regression models with pain (1/0) as the outcome variable were used to check the association of pain with the above mentioned variables. Results: 54.8% of patients with PD experience pain. Presence of sensory symptoms was significantly associated with the pain group (42.1%) than the no pain group (21%). Pain was more pronounced on the side with predominant motor symptoms (72%) and in 68.4 % patients pain responded to dopaminergic treatment. Musculoskeletal pain (82.5%) was the commonest type and lower limbs were the commonest site of pain (43.2%). Conclusion: Pain in Parkinson’s disease has multiple dimensions and characteristics. Pain itself may be the reason for early diagnosis. Proper classification of pain will help in improved management of these patients.
5.Antifungal Activity of Securinine against Some Plant Pathogenic Fungi.
Ashok K SINGH ; M B PANDEY ; Sarita SINGH ; Anil K SINGH ; U P SINGH
Mycobiology 2008;36(2):99-101
The alkaloid securinine was assessed against spore germination of some plant pathogenic and saprophytic fungi (Alternaria alternata, Alternaria brassicae, Alternaria brassicicola, Curvularia lunata, Curvularia maculans, Curvularia pallenscens, Colletotrichum musae, Colletotrichum sp., Erysiphe pisi, Helminthosporium echinoclova, Helminthosporium spiciferum, Heterosporium sp.). Spore germinations of all the tested fungi were inhibited. Alternaria brassicicola, C. lunata, C. pallenscens and H. spiciferum were highly sensitive as complete inhibition of spore germination was observed at very low concentrations (200 ppm).
Alternaria
;
Azepines
;
Brassica
;
Colletotrichum
;
Fungi
;
Germination
;
Helminthosporium
;
Heterocyclic Compounds, Bridged-Ring
;
Lactones
;
Musa
;
Phyllanthus
;
Piperidines
;
Plants
;
Spores
6.Acute Paraplegia in a Toddler: A Diagnostic Journey Compounding the Challenge in Management: A Case Report
Goh JH ; Fazir M ; Zainal-Abidin NA ; Amir D ; Singh M
Malaysian Orthopaedic Journal 2016;10(2):56-60
Spinal tuberculosis is not common in the paediatric age
group. Initial clinical features are often vague and non
specific until the disease progresses to later stages. We
highlight the diagnostic difficulties and management
challenges of a complicated extradural tuberculoma with
neurological deficits in a very young girl.
Tuberculosis, Spinal
7.Incidence of Cancer in Fiji
K. Singh ; K. P. Singh ; M. Singh ; H. K. Singh
Fiji Medical Journal 1981;9(10):164-170
8.Serum folic acid levels in epilepsy patients before and after phenytoin therapy
Abhishek Singh Nayyar ; Mubeen Khan ; GT Subhas ; B Nataraju ; Vijayalakshmi KR ; Anitha M.
Neurology Asia 2012;17(3):205-208
Background & Objectives: Low serum folate level is often reported as an adverse drug sequela of long
term phenytoin usage seen with prolonged duration of phenytoin therapy. There is no previous study
to prospectively track the serum folate level with usage of phenytoin, which is the objective of this
study. Methods: Twenty-fi ve patients between the ages of 18-50 years diagnosed to have epilepsy and
planning to start phenytoin were recruited in this study. Assessment of serum folic acid was done by
chemiluminiscent method prior to the start of phenytoin and after 6 months of treatment. The serum
folate level of 10 age and sex matched healthy control was also taken. Results: The average serum
folate level was 7.48 + 2.04 ng/mL prior to the start of phenytoin therapy, which fell to 3.9 + 1.95
ng/mL after 6-month of phenytoin therapy (p-value <0.001). The average serum folate level for the
age and sex matched 10 control samples was 14.46 + 2.81 ng/mL.
Conclusion: A signifi cant fall of serum folic acid levels is seen in epilepsy patients after 6 months
treatment with phenytoin.
9.Serum total protein, albumin and advanced oxidation protein products (AOPP) - implications in oral squamous cell carcinoma
Abhishek Singh Nayyar ; Mubeen Khan ; Vijayalakshmi KR ; Suman B ; Gayitri HC ; Anitha M
The Malaysian Journal of Pathology 2012;34(1):47-52
Background: The role of oxygen free radicals in the initiation, promotion and progression of
carcinogenesis and the protective role of anti-oxidant defenses have been the subject of much
speculation in the recent past with confl icting reports in the literature. Objectives: The aim of this
study was to measure the concentration/levels of serum total proteins, albumin and advanced oxidation
protein products as markers of oxidative stress in sera of patients with an oral pre-cancerous lesion
and frank oral cancer. Materials and methods: The study consisted of sera analysis of 30 new patients
of histologically proven well-differentiated, oral squamous cell carcinoma and 10 patients, clinically
diagnosed with a potentially malignant epithelial lesion, speckled leukoplakia, aged between 40 to
60 years, in addition to 25 healthy controls. One way analyses of variance were used to test the
difference between groups. The normality of data was checked before the statistical analysis was
performed. Results: The study revealed variations in sera levels of albumin and advanced oxidation
protein products to be statistically signifi cant (p < 0.001). Conclusion: The results obtained emphasize
the need for more studies with larger sample sizes to be conducted before a conclusive role could be
drawn in favour of sera levels of total protein, albumin and advanced oxidation protein products as
markers of diagnostic signifi cance and of the transition from the various oral pre-cancerous lesions
and conditions into frank oral cancers.
10.Does Oral Lansoprazole Really Reduce Gastric Acidity in VLBW Premature Neonates?
Tham Sock Ying ; Rogers Ian M ; Samuel KF ; Singh A ; Ong King Kok
The Medical Journal of Malaysia 2012;67(3):284-288
Premature neonates of very low birth weight (VLBW) whose
treatment required the use of naso-gastric tube feeding were investigated. 10 infants suspected of having GERD (gastroesophageal reflux) received oral lansoprazole therapy by tube administration. 9 other infants formed a control group.
In the treated group a fasting pH was determined before
treatment and again after 7 days treatment. The control
group was similarly assessed at an interval of 7 days. Despite acid reduction, the post-treatment pH mean of 1.31 would continue to pose a threat to the esophageal mucosa. The physiology of neonatal acid secretion is discussed to explain these findings.