Stem/progenitor cells contribute to normal development of organs, but their mutation may lead to many human diseases including cancer. Stem/progenitor cells and some of the cancer cells have the same abilities of self-renewal and differentiation, suggesting that tumors were initiated from mutated stem/progenitor cells, the cancer stem/progenitor cells. The recent studies on the origin of the non-Hodgkin's lymphomas has proved that the second-hit aggravates gene mutation in lymphocytic progenitor cells, leading to the generation of lymphoma. This review summarizes the current advances in the studies of the second-hit at stem/progenitor cells in oncogenesis of B-cell non-Hodgkin's lymphoma.
Humans ; Leukemia ; etiology ; Lymphoma ; etiology ; Mutation ; Neoplastic Stem Cells ; cytology

Abdominal Pain ; etiology ; Acute Pain ; etiology ; Child ; Humans ; Lymphoma ; complications

Child ; Humans ; Lymphoma, T-Cell ; complications ; Panniculitis ; etiology ; Subcutaneous Tissue

Castleman Disease ; complications ; Humans ; Lymphoma, Large B-Cell, Diffuse ; etiology

Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis* ; Death, Sudden/etiology*

Cryoglobulinemia ; etiology ; Diabetes Mellitus ; etiology ; Fatty Liver ; etiology ; Hepatitis C, Chronic ; complications ; Humans ; Lymphoma, B-Cell ; etiology

Aged ; B-Lymphocytes ; pathology ; Histiocytic Sarcoma ; complications ; Humans ; Lymphoma, B-Cell ; etiology ; Lymphoma, Large B-Cell, Diffuse ; etiology ; pathology ; Male

Adolescent ; Humans ; Ileal Diseases ; etiology ; Intussusception ; etiology ; Lymphoma, B-Cell ; complications ; Male

Acute Kidney Injury ; etiology ; Fanconi Syndrome ; etiology ; Female ; Humans ; Lymphoma, Non-Hodgkin ; complications ; Middle Aged

Child ; Child, Preschool ; Humans ; Male ; Mycoses ; etiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; complications ; drug therapy ; Rhinitis ; etiology ; Sinusitis ; etiology