Documented lymphoma of the kidney is rare and its diagnosis is very difficult. In most cases the diagnosis is made after removal or biopsy of a kidney for suspected primary renal tumor or at autopsy. If a lymphoma of the kidney were primary, early diagnosis and aggressive treatment of the local area would be essential for a cure. Herein we report a case of primary renal lymphoma in 38-yr-old man who was treated with surgical intervention and combination chemotherapy.
Autopsy ; Biopsy ; Diagnosis ; Drug Therapy, Combination ; Early Diagnosis ; Kidney* ; Lymphoma*

The authors have studied six patients with histologically proven primary malignant lymphoma of the brain which is still a rare primary brain tumor. The clinical, radiological and pathological findings with results of the treatment are presented. All cases showed a good response to radiation therapy. Therefore, the early diagnosis by computerized tomography scan followed by biopsy or excision is considered to be very important for the BEST results in the treatment. Related reports are discussed briefly.
Biopsy ; Brain Neoplasms ; Brain* ; Drug Therapy ; Early Diagnosis ; Humans ; Lymphoma*

The primary lymphoma in the lung is very rare. Most of the primary pulmonary lymphomas, which represent 3-4 % of extra-nodal lymphomas, are low-grade B-cell lymphoma. The low-grade B-cell lymphomas progress slowly and the prognosis of these are more favorable than that of the nodal lymphomas. However, high-grade forms progress rapidly with more severe course. The diagnosis of primary pulmonary lymphomas generally relies on the histopathologic findings of lung specimens obtained by surgical excision of the lesions or open-lung biopsy. Recently, less aggressive biopsies(transbronchial, transthoracic) and/or immunocyto -chemical, immunochemical and gene rearrangement studies on materials obtained by bronchoalveolar lavage have been used occasionally. The treatment of the primary pulmonary lymphomas has not been precisely codified. Several clinical data suggest that limited surgery or non -aggressive chemotherapy can provide long-term survival in patients with such slowly developing neoplasm, and demonstrated the need for the development of noninvasive diagnostic methods. In this study, we report a case of high-grade B-cell lymphoma of the lung which was treated with combination chemotherapy.
B-Lymphocytes ; Biopsy ; Bronchoalveolar Lavage ; Diagnosis ; Drug Therapy ; Drug Therapy, Combination ; Gene Rearrangement ; Humans ; Lung* ; Lymphoma* ; Lymphoma, B-Cell ; Prognosis

Aged ; Bendamustine Hydrochloride ; therapeutic use ; Humans ; Lymphadenopathy ; diagnosis ; Lymphoma ; diagnosis ; drug therapy ; Male ; Rituximab ; therapeutic use

Primary nodal marginal zone B-cell lymphoma (MZBCL) is recognized as a rare and distinct entity. The rate of histologic transformation into diffuse large B-cell lymphoma (DLBCL) seems lower than the rate of transformation in follicular lymphoma. We herein report a rare case ofnodal MZBCL showing transformation into DLBCL. The patient was a 73-year-old female withcervical lymphadenopathy. On the initial biopsy, the lymph node architecture was diffuselyeffaced with an extensive interfollicular and parafollicular infiltrate of monocytoid B-cells. Therewere scattered large blastic B-cells without formations of compact sheets. The diagnosis ofnodal MZBCL was made. The patient did not receive chemotherapy and was treated with aconservatively supportive regimen. Forty two months later, the patient developed a new cervicallymphadenopathy and a biopsy was performed. Histologically, the lymph node revealeddiffuse sheets of transformed large B-cells showing prominent nucleoli. The diagnosis ofDLBCL transformed from nodal MZBCL was made. The patient was treated with 3 cycles ofcombined CHOP chemotherapy and she showed clinical improvement. These observationssuggest that an untreated primary nodal MZBCL may undergo high-grade transformation.
Aged ; B-Lymphocytes ; Biopsy ; Diagnosis ; Drug Therapy ; Female ; Humans ; Lymph Nodes ; Lymphatic Diseases ; Lymphoma ; Lymphoma, B-Cell ; Lymphoma, B-Cell, Marginal Zone* ; Lymphoma, Follicular

OBJECTIVETo investigate the best diagnostic and therapeutic method for primary lymphoma of the spleen.

METHODSClinicopathologic features of 23 patients treated from January 1956 to August 1999 were analyzed retrospectively.

RESULTSAll patients but one for exploration only (96%) underwent resection of the tumor. They accepted chemotherapy after operation. 23 patients were confirmed pathologically. B-cell type non-Hodgkin's lymphoma was noted in 21 patients and T-cell letion in 2. According to Ahman's staging, 9 patients belonged to stage I, 8 stage II, and 6 stage III. The 5-year survival rates were 50%, 40% and 16% respectively.

CONCLUSIONSThe diagnosis of splenic lymphoma is dependent mainly on B-ultrasound examination and CT scanning. Splenectomy combined with chemotherapy may provide optimum therapy for patients with splenic lymphoma.

Adult ; Aged ; Combined Modality Therapy ; Drug Therapy ; Female ; Humans ; Lymphoma ; diagnosis ; drug therapy ; surgery ; Male ; Middle Aged ; Retrospective Studies ; Splenectomy ; Splenic Neoplasms ; diagnosis ; drug therapy ; surgery

Lymphomatous involvement of the heart is extremely rare at initial diagnosis and presentation of malignant lymphoma. Worldwide, only a few cases have been diagnosed and treated during life and only four cases were diagnosed before death in Korea. We report a case of non-Hodgkin's lymphoma with two right atrial masses detected by chest computed tomography and transesophageal echocardiography. The patient was an 80 year- old man and the presenting symptoms included generalized weakness, weight loss, constipation and low abdominal pain. For diagnosis, the mass of the perinephric area was biopsied under ultrasonographic guidance, and pathologically it was determined to be malignant lymphoma, diffuse large B cell type. The patient was treated with continuous low dose cyclophosphamide and prednisolone vice standard chemotherapy because of advanced age and renal dysfunction. After 2 months of treatment the masses in the atrium and the intraabdominal masses disappeared.
Abdominal Pain ; Constipation ; Cyclophosphamide ; Diagnosis ; Drug Therapy ; Echocardiography, Transesophageal ; Heart ; Humans ; Korea ; Lymphoma* ; Lymphoma, Non-Hodgkin* ; Prednisolone ; Thorax ; Weight Loss

Although in the past two decades there has been a sharp rise in the incidence of extranodal primary lymphomas, non-Hodgkin's lymphoma (NHL) of the female genital tract is still rare. There is still no consensus on the management of cervical lymphomas. The malignant lymphoma localized in uterine cervix is rare and characteristically symptom free expressed. A 26-year-old woman presented in March 2004 with uterine bleeding. After the patient underwent punch biopsy, primary cervical malignant lymphoma was diagnosed. Six courses of chemotherapy were administered in an adjuvant setting. Thirty-nine months (May 2007) after the diagnosis the patient was alive and without signs of recurrent disease. In this report, one case of primary cervical lymphoma diagnosed by punch biopsy is reported and associated literature is discussed.
Adult ; Biopsy ; Cervix Uteri* ; Consensus ; Diagnosis ; Drug Therapy ; Female ; Humans ; Incidence ; Lymphoma* ; Lymphoma, Non-Hodgkin ; Uterine Cervical Neoplasms ; Uterine Hemorrhage

To characterize the clinical manifestations, and histologic features of CNS lymphoma in immunocompetent patients, we collected 15 cases of biopsy proven primary CNS lymphoma. Evidences of systemic lymphoma, HIV infection, and immune-compromising diseases were absent at the diagnosis. Brain MRI had been taken before radiation or chemotherapy, and pathologic specimens were classified according to working formulation and some cases underwent immunological marker studies. Mean duration of illness was 1. 8 months, mild CSF protein elevation(mean=58mg%) was observed in 5 of 6 patients, CSF cytology was positive in 2 of 7, and the recurrence rate was 69%. In MR imaging, tumor size was variable, and 5 patients had multiple lesions at diagnosis. All patients showed homogeneous(87%) or heterogeneous(13%) gadolinium enhancement, and secondary tumor change was shown in I case. The tumor had high tendency in abutting on CSF space(60%), and there was no relationship between histologic types and MR imaging I s. Classified by working formulation, the intermediate grade lymphomas(diffuse large cell and small cell cleaved types) were 14 out of 15(93%) and I showed low grade(small lymphocytic). B-cell lymphoma was 8 out of 9, and T-cell was only 1. As compared with the previous reported pathologic data of AIDS-related CNS lymphoma, the histology of lymphoma in immunocompetent patients were less malignant than those related to AIDS and immune-compromised patients.
Biopsy ; Brain ; Diagnosis ; Drug Therapy ; Gadolinium ; HIV Infections ; Humans ; Lymphoma* ; Lymphoma, B-Cell ; Magnetic Resonance Imaging ; Recurrence ; T-Lymphocytes

Accurate diagnosis of autoimmune pancreatitis (AIP) is important to clinicians since it is difficult to differentiate AIP from pancreatic malignancies. Furthermore, unlike pancreatic malignancies, AIP has dramatic response to steroids. A 61-years-old man presented with acute pancreatitis. Imaging studies showed two separate pancreatic masses, irregular narrowing of main pancreatic duct, and a renal mass that highly suggested AIP. Endoscopic ultrasound-guided core needle biopsy of the pancreatic masses and ultrasound-guided biopsy of the renal mass revealed peripheral T-cell lymphoma. The patient is currently undergoing chemotherapy. We present a case of pancreatic lymphoma masquerading as AIP with literature review.
Biopsy ; Biopsy, Large-Core Needle ; Diagnosis ; Drug Therapy ; Humans ; Lymphoma* ; Lymphoma, T-Cell, Peripheral ; Pancreatic Ducts ; Pancreatic Neoplasms ; Pancreatitis* ; Steroids