1.A case of leukemia-associated arthritis: identification of leukemic cells in synovial fluid by light microscopy.
Sung Soo YOON ; Han Do YOUN ; Cheolwon SUH ; Yung Jue BANG ; Sung Jae CHOI ; Byung Kook KIM ; Noe Kyeong KOM ; Eui Chong KIM
Journal of Korean Medical Science 1987;2(4):255-258
One case of arthritis complicating leukemia is described in which leukemic cells were identified in synovial fluid by light microscopy. Although arthritis is a well-known manifestation of leukemia with an incidence of 13.5%, the pathogenesis often is unclear, and the direct demonstration of leukemic cells in synovial fluid has been very uncommon. A 16 year-old male patient was admitted due to left elbow joint pain and swelling. Synovial fluid examination revealed blast cells and this finding has directed to a final diagnosis of acute lymphoblastic leukemia.
Adolescent
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Arthritis/*etiology
;
Humans
;
Leukemia-Lymphoma, Adult T-Cell/*complications/diagnosis/pathology
;
Male
2.A Case of Enteropathy-associated T-cell Lymphoma Presenting with Recurrent Hematochezia.
Dong Hoon YANG ; Seung Jae MYUNG ; Hye Sook CHANG ; Jin Woo SONG ; Suk Kyun YANG ; Gin Hyug LEE ; Hwoon Yong JUNG ; Weon Seon HONG ; Jin Ho KIM ; Young Il MIN ; Hee Cheol KIM ; Jooryung HUH ; Heung Bum OH
The Korean Journal of Gastroenterology 2003;42(6):527-532
Enteropathy-associated T-cell lymphoma (EATL) is an unusual primary gastrointestinal lymphoma, particularly associated with celiac sprue. This tumor usually affects the jejunum and grossly presents as multiple circumferential ulcers without the formation of definite tumor masses. Moreover, mesenteric lymph nodes are commonly involved. The patients have typically suffered from abdominal pain, diarrhea, or weight loss whereas some patients may manifest with nonspecific symptoms for a period of years or an acute emergency of perforation, obstruction, or hemorrhage. The clinical course of EATL is very unfavorable and the prognosis is poor. Both celiac sprue and EATL are very rare diseases in Asia, except India and Middle East. We report a 60-year-old male diagnosed as having EATL after segmental small bowel resection, who presented with recurrent gastrointestinal bleeding.
Celiac Disease/*complications
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Gastrointestinal Hemorrhage/*etiology
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Humans
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Intestinal Neoplasms/complications/*diagnosis/pathology
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Intestine, Small/pathology
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Lymphoma, T-Cell/complications/*diagnosis/pathology
;
Male
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Middle Aged
;
Recurrence
3.Case of Small Bowel Perforation due to Enteropathy-Type T-Cell Lymphoma.
Yong Seok KIM ; Yoo Shin CHOI ; Jun Seok PARK ; Beom Gyu KIM ; Seong Jae CHA ; Kyong Choun CHI ; Sung Jun PARK ; In Taik CHANG ; Sung Il PARK
Yonsei Medical Journal 2009;50(6):859-861
Enteropathy-type T-cell lymphoma (ETTL) is a rare disease with a poor prognosis. According to the World Health Organization (WHO) classification, it is a subtype of the peripheral T-cell lymphomas. This disease is associated with gluten-sensitive enteropathy, has a high risk of intestinal perforation and obstruction, and is refractory to chemotherapeutic treatment. We report the case of a 73-year-old woman who was diagnosed with enteropathy-type T-cell lymphoma of the small intestine, which was positive for the markers of cytotoxic T cells, CD3, CD8, and CD56, on immunohistochemical staining after resection of the perforated terminal ileum.
Aged
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Celiac Disease/*complications/pathology
;
Female
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Gastrointestinal Neoplasms/*complications/pathology
;
Humans
;
Intestinal Perforation/*diagnosis/*etiology/pathology
;
Lymphoma, T-Cell/*complications/pathology
4.Simultaneous Occurrence of Angioimmunoblastic T-cell Lymphoma and Plasma Cell Leukemia.
Mi Ae JANG ; Seung Tae LEE ; Hee Jin KIM ; Seokjin KIM ; Sun Hee KIM
Annals of Laboratory Medicine 2015;35(1):149-151
No abstract available.
Aged
;
Humans
;
Leukemia, Plasma Cell/complications/*diagnosis/pathology
;
Leukocytosis
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Lymph Nodes/pathology
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Lymphoma, T-Cell/complications/*diagnosis/pathology
;
Male
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Paraproteinemias/complications
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Polymerase Chain Reaction
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Receptors, Antigen, T-Cell, gamma-delta/genetics/metabolism
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Tomography, X-Ray Computed
5.Hepatosplenic gammadelta T cell lymphoma and its relationship with Epstein-Barr virus infection.
Xiao-Ning GAO ; Suo-Qin TANG ; Ying LIU ; Jian-Wen WANG
Journal of Experimental Hematology 2006;14(6):1134-1137
To explore the clinical and pathological characteristics of hepatosplenic gammadelta T-cell lymphoma and its relationship with Epstein-Barr virus infection, the clinical features of a 9-year-old girl with hepatosplenic gammadelta T-cell lymphoma were investigated, the smears of bone marrow was stained with Wright' s stain, biopsies of bone marrow and liver specimen were embedded in plastic and sliced about 4 microm in thickness and routinely stained with HE staining, the immunohistochemical staining was used to mark the tumor cells, and EBER probes were used to detect Epstein-Barr virus RNA. The results showed that the girl presented with prolonged fever, anemia, thrombocytopenia, hepatosplenomegaly, chronic active Epstein-Barr virus infection, and elevated levels of serum ferritin and lactate dehydrogenase. Bone marrow aspirate revealed the infiltration of atypical lymphocytes in the bone marrow stroma. The liver biopsy specimen revealed the infiltration of lymphocytes in the sinusoids, which was positive for the T-cell associated marker CD3 and activated cytotoxicity-associated marker granzyme B. In-situ hybridization analysis with EBER probes revealed that the above-mentioned characteristics were negative in neoplastic cells. It is concluded that hepatosplenic gammadelta T-cell lymphoma is a disease with distinctive clinical, histopathologic, and phenotypic characteristics. Hepatic and/or splenic and/or bone marrow biopsy with combined phenotype is beneficial to diagnosis. Epstein-Barr virus infection is late event involving an already transformed gammadelta T-cell clone.
Child
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Epstein-Barr Virus Infections
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complications
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Female
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Humans
;
Liver Neoplasms
;
diagnosis
;
pathology
;
virology
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Lymphoma, T-Cell, Peripheral
;
diagnosis
;
pathology
;
virology
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Receptors, Antigen, T-Cell, gamma-delta
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analysis
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Splenic Neoplasms
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diagnosis
;
pathology
;
virology
6.Recent advances in enteropathy-associated T-cell lymphoma.
Jian SUN ; Di YANG ; Zhao-hui LU ; Jie CHEN
Chinese Journal of Pathology 2010;39(10):717-720
Antigens, CD
;
metabolism
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CD3 Complex
;
metabolism
;
Celiac Disease
;
complications
;
Chromosome Aberrations
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Chromosomes, Human, Pair 9
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Diagnosis, Differential
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Enteropathy-Associated T-Cell Lymphoma
;
complications
;
genetics
;
metabolism
;
pathology
;
Humans
;
Integrin alpha Chains
;
metabolism
;
Intestinal Mucosa
;
pathology
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Ki-1 Antigen
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metabolism
;
Lymphoma, Extranodal NK-T-Cell
;
pathology
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Lymphoma, Large B-Cell, Diffuse
;
pathology
7.Sinonasal natural killer/T-cell lymphoma presenting as pyrexia of unknown origin with nasal symptoms.
Betsy K H SOON ; Xin-Rong LIM ; Deborah H L NG ; Ming-Yann LIM
Singapore medical journal 2014;55(7):e109-11
A 68-year-old Chinese man presented with an eight-month history of pyrexia of unknown origin and chronic sinusitis despite multiple courses of antibiotics. He underwent extensive investigations, including workups for infections, chronic granulomatous diseases and malignancy. Nasal biopsies were performed twice under local anaesthesia, but did not show any evidence of malignancy. Eventually, the patient was diagnosed with natural killer (NK)/T-cell lymphoma, nasal variant, based on histopathological findings from harvested deep tissue obtained via functional endoscopic sinus surgery. This study highlights that, for patients presenting with pyrexia of unknown origin and nasal symptoms, NK/T-cell lymphoma must be considered as a differential diagnosis. Generous amounts of tissue should be harvested under general anaesthesia rather than limited tissue under local anaesthesia, in order to facilitate and ensure a definitive diagnosis.
Aged
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Anti-Bacterial Agents
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chemistry
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Biopsy
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China
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Humans
;
Lymphoma, Extranodal NK-T-Cell
;
diagnosis
;
diagnostic imaging
;
pathology
;
Male
;
Nasal Cavity
;
pathology
;
Nose Neoplasms
;
complications
;
diagnosis
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radiotherapy
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Prognosis
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Radiography
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Radiotherapy
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Sinusitis
;
complications
;
diagnosis
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Treatment Outcome
8.Primary cutaneous T-cell lymphoma of the penis complicated by Fournier gangrene: a case report.
Zun-lin ZHOU ; Chuan-yun WANG ; Zhi-shun XU ; Bao-zhong ZHENG
National Journal of Andrology 2008;14(6):542-544
OBJECTIVETo explore the clinical presentation, pathologic characteristics, diagnosis and treatment of cutaneous T-cell lymphoma of the penis.
METHODSA 49-year-old man presented with painful swelling and inflammation of the foreskin, failed to respond to antibiotic treatment and dorsal incision, and was instead complicated by Fournier gangrene. Then he underwent debridement and pathological examination.
RESULTSPathological results indicated cutaneous T-cell lymphoma of the penis. Immunohistochemistry showed CD3 and CD45 RO to be positive, but CD30, CD79a, CD20 and HMB negative. The patient was treated by interferon alpha and ultraviolet B for 2 weeks, followed by total removal of the external genitalia because of necrosis of the corpus spongiosum, which involved the scrotum and right testis on pathological examination.
CONCLUSIONCutaneous T-cell lymphoma of the penis is a rare condition and easily mis diagnosed in the early phase. Definitive diagnosis depends on pathological study.
CD3 Complex ; analysis ; Diagnosis, Differential ; Fournier Gangrene ; etiology ; pathology ; Humans ; Immunohistochemistry ; Leukocyte Common Antigens ; analysis ; Lymphoma, T-Cell, Cutaneous ; complications ; metabolism ; pathology ; Male ; Middle Aged ; Penile Neoplasms ; complications ; metabolism ; pathology
9.Marked Increase of Circulating Double-Negative gammadelta T Cells in a Patient With Hydroa Vacciniforme-Like Lymphoma.
Sang Yong SHIN ; Chang Hun PARK ; Duck CHO ; Hee Jin KIM ; Sun Hee KIM
Annals of Laboratory Medicine 2016;36(3):268-270
No abstract available.
Child, Preschool
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Female
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Flow Cytometry
;
Humans
;
Hydroa Vacciniforme/*diagnosis/pathology
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Immunophenotyping
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Lymphocytosis/complications
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Lymphoma/*diagnosis
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Receptors, Antigen, T-Cell, gamma-delta/genetics/*metabolism
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STAT3 Transcription Factor/genetics/metabolism
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Sequence Analysis, DNA
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Skin/metabolism
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T-Lymphocytes/*metabolism
10.Hepatocellular Carcinoma with Immature T-Cell (T-lymphoblastic) Proliferation.
Shin EUN ; Youn Kyung JEON ; Ja June JANG
Journal of Korean Medical Science 2010;25(2):309-312
Indolent T-lymphoblastic proliferation has been rarely reported in the upper aerodigestive tract. The lymphoid cells associated with this condition have the morphological and phenotypical features of immature thymocytes. However, their pathogenesis and biology are unknown. We present an unusual type of tumor infiltrating lymphocytes in a case with hepatocellular carcinoma, presumed to be a T-lymphoblastic proliferation. A 58-yr-old female patient presented with indigestion and a palpable epigastric mass. The abdominal computed tomography revealed a mass in the S6 region of the liver. A hepatic segmentectomy was performed. Microscopic examination showed dense isolated nests of monomorphic lymphoid cells within the tumor. Immunohistochemically, the lymphoid cells were positive for CD3, terminal deoxymucleotide transferase (TdT) and CD1a. In addition, they showed dual expression of CD4 and CD8. The polymerase chain reaction used to examine the T-cell antigen receptor gamma gene rearrangement showed polyclonal T-cell proliferation. This is the second case of hepatocellular carcinoma combined with indolent T-lymphoblastic proliferation identified by an unusual tumor infiltrating lymphocytes.
Antigens, CD3/metabolism
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Antigens, CD4/metabolism
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Antigens, CD8/metabolism
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Carcinoma, Hepatocellular/*diagnosis/pathology/secondary
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DNA Nucleotidylexotransferase/metabolism
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Female
;
Humans
;
Liver Neoplasms/*diagnosis/immunology/pathology
;
Lymphocytes, Tumor-Infiltrating/*pathology
;
Mastectomy, Segmental
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Middle Aged
;
Precursor Cells, T-Lymphoid/*pathology
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/*pathology
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Tomography, X-Ray Computed