1.Dermatofibroma in Patient with Relapsing Primary Cutaneous Anaplastic Large Cell Lymphoma.
Dongyun SHIN ; Do Young KIM ; Min Geol LEE ; Dae Suk KIM
Korean Journal of Dermatology 2015;53(6):482-484
No abstract available.
Histiocytoma, Benign Fibrous*
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Humans
;
Lymphoma, Large-Cell, Anaplastic
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
2.Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma That Developed after Lymphomatoid Papulosis.
Jae Wan GO ; Shin Han KIM ; Sang Yeop YI ; Han Kyoung CHO
Korean Journal of Dermatology 2010;48(12):1081-1085
Lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) are grouped under the category of cutaneous T-cell lymphomas as CD30+ lymphoproliferative disorders. Though LyP is clinically characterized by chronic recurrent papulonodular cutaneous lesions, it shows malignant features on the histologic findings. LyP is associated with lymphomas, including primary cutaneous ALCL, mycosis fungoides and other lymphoproliferative disorders. A few cases of LyP related to ALCL have been reported in Korea. We report here on an interesting case of primary cutaneous ALCL that developed in succession after LyP in a 38-year-old female.
Adult
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Female
;
Humans
;
Korea
;
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell
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Lymphoma, T-Cell, Cutaneous
;
Lymphomatoid Papulosis
;
Lymphoproliferative Disorders
;
Mycosis Fungoides
3.Primary Cutaneous Anaplastic Large Cell Lymphoma:Report of One Case.
Han WANG ; Ping-Ping GUO ; Zhen HUO ; Han-Huan LUO
Acta Academiae Medicinae Sinicae 2022;44(4):737-740
Primary cutaneous anaplastic large cell lymphoma is a rare non-Hodgkin's lymphoma.The tumor cells have the characteristics of anaplastic cells,expressing CD30 but not anaplastic lymphoma kinase.In this study,we reported a case of primary cutaneous anaplastic large cell lymphoma in a Tibetan child and summarized the clinicopathological features,aiming to strengthen the understanding of this disease.
Child
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Humans
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Ki-1 Antigen
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Lymphoma, Primary Cutaneous Anaplastic Large Cell
;
Skin Neoplasms/pathology*
4.A Case of Multifocal Primary Cutaneous Anaplastic Large Cell Lymphoma Managed without Surgical Treatment
Joonho LIM ; Eonju PARK ; Seokchan EUN
Korean Journal of Head and Neck Oncology 2019;35(2):77-80
Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is rare among skin malignancies. C-ALCL usually manifests as reddish or violet nodules. Surgical excision or radiation therapy is generally considered as first-line therapy, but a clinically aggressive disease may require multiagent chemotherapy. Establishing a proper diagnosis of C-ALCL is challenging but should be made to avoid inappropriate treatment and its consequences. The authors report a case of medically resolved C-ALCL in an 81-year-old man presented with well-defined nodular lesions on the forehead.
Aged, 80 and over
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Diagnosis
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Drug Therapy
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Forehead
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Humans
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Lymphoma, Large-Cell, Anaplastic
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell
;
Lymphoma, T-Cell
;
Skin
;
Viola
5.A Case of Primary Cutaneous Anaplastic Large Cell Lymphoma on Palm.
Byeong Su KIM ; Moon Hyung YOU ; Joon Goon KIM ; Yeon Woong KIM ; Dong Hoon SHIN ; Jong Soo CHOI
Korean Journal of Dermatology 2017;55(9):610-614
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare primary cutaneous lymphoma that is predominantly composed of large lymphoid cells that express the CD30 antigen. The skin lesion of PCALCL is usually single, ulcerative, and located on the trunk or extremities and rarely the palm. A 25-year-old woman presented with a plaque on the left palm for 20 days. The plaque was walnut-sized and purple to gray colored with erosion in the center. Histopathologic examination showed infiltration of large atypical cells in the dermis. The large tumor cells showed positivity for CD3, CD4, and CD30 and negativity for CD8, CD20, epithelial membrane antigen, and anaplastic lymphoma kinase. PET-CT showed no other hypermetabolic lesion except that on the left palm, and we finally arrived at a diagnosis of PCALCL. The patient was treated with an intralesional injection of methotrexate (25 mg/mL, 0.45 cc). After 3 months of treatment, the walnut-sized plaque had disappeared and a peripheral hyperpigmented patch remained.
Adult
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Antigens, CD30
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Dermis
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Diagnosis
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Extremities
;
Female
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Humans
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Injections, Intralesional
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Lymphocytes
;
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
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Methotrexate
;
Mucin-1
;
Phosphotransferases
;
Skin
;
Ulcer
6.A Case of Primary Cutaneous Anaplastic Large Cell Lymphoma with Extensive Limb Disease.
Jae Ho BYEON ; In Sook WOO ; Won Jik LEE ; Sung Hee KAM ; Chi Wha HAN ; Yun Hwa JUNG
Korean Journal of Medicine 2015;89(3):353-357
Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of malignant non-Hodgkin lymphoma, in which 40% of the cases show spontaneous regression without aggressive treatment. Surgery and focal radiation therapy are the primary forms of treatment for this disease; however, if pcALCL is accompanied by multifocal skin lesions, chemotherapy is also common. The prognosis for pcALCL is generally excellent, with a 5-year survival rate of 85-100%. However, pcALCL with extensive limb disease typically has a poor prognosis. Here, we present a case of pcALCL with extensive limb disease that resulted in the patient's death, despite the use of aggressive chemotherapy.
Drug Therapy
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Extremities*
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Lymphoma
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Lymphoma, Non-Hodgkin
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
;
Prognosis
;
Skin
;
Survival Rate
7.A Case of Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma, Small Cell Variant.
Jung MIN ; Han Saem KIM ; Sang Hyeon HWANG ; Heun Joo LEE ; Jae Hui NAM ; Ho Joo JUNG ; Ji Hye PARK ; Ga Young LEE ; Won Serk KIM
Korean Journal of Dermatology 2015;53(4):304-309
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare cutaneous T-cell lymphoma. Most cases are composed of large anaplastic cells. However, it presents a wide spectrum of histologic patterns. In the small cell variant, a small-sized pleomorphic cell morphology can be seen. A 74-year-old woman presented with an 8-month history of asymptomatic ulcerative plaque and satellite nodule on the right calf. Her past medical history was not specific. The histologic findings on punch biopsy specimens showed a malignant small round cell tumor on both lesions. The tumor cells had large pleomorphic nuclei with multinucleation and some eosinophilic cytoplasm. We performed immunohistochemical staining to rule out neuroectodermal tumor, neuroendocrine tumor, melanoma, lymphoma, and so on. However, the staining results were negative for pancytokeratin, CD3, CD20, CD99, chromogranin A, synaptophysin, CD56, ALK, HMB45, desmin, kappa, lambda, myoglobin, and S-100 protein. CT, MRI, and PET-CT were negative for extracutaneous involvement. Total excision was done, and additional immunohistochemical staining was performed to confirm the origin of the tumor. Staining results for vimentin, LCA, CD4, and CD30 were positive. We concluded that these findings were consistent with the small cell variant CD30+ PCALCL, which occurs rarely.
Aged
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Biopsy
;
Chromogranin A
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Cytoplasm
;
Desmin
;
Eosinophils
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Female
;
Humans
;
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic*
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell
;
Lymphoma, T-Cell, Cutaneous
;
Magnetic Resonance Imaging
;
Melanoma
;
Myoglobin
;
Neuroectodermal Tumors
;
Neuroendocrine Tumors
;
S100 Proteins
;
Synaptophysin
;
Ulcer
;
Vimentin
8.A Case of Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma, Small Cell Variant.
Jung MIN ; Han Saem KIM ; Sang Hyeon HWANG ; Heun Joo LEE ; Jae Hui NAM ; Ho Joo JUNG ; Ji Hye PARK ; Ga Young LEE ; Won Serk KIM
Korean Journal of Dermatology 2015;53(4):304-309
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare cutaneous T-cell lymphoma. Most cases are composed of large anaplastic cells. However, it presents a wide spectrum of histologic patterns. In the small cell variant, a small-sized pleomorphic cell morphology can be seen. A 74-year-old woman presented with an 8-month history of asymptomatic ulcerative plaque and satellite nodule on the right calf. Her past medical history was not specific. The histologic findings on punch biopsy specimens showed a malignant small round cell tumor on both lesions. The tumor cells had large pleomorphic nuclei with multinucleation and some eosinophilic cytoplasm. We performed immunohistochemical staining to rule out neuroectodermal tumor, neuroendocrine tumor, melanoma, lymphoma, and so on. However, the staining results were negative for pancytokeratin, CD3, CD20, CD99, chromogranin A, synaptophysin, CD56, ALK, HMB45, desmin, kappa, lambda, myoglobin, and S-100 protein. CT, MRI, and PET-CT were negative for extracutaneous involvement. Total excision was done, and additional immunohistochemical staining was performed to confirm the origin of the tumor. Staining results for vimentin, LCA, CD4, and CD30 were positive. We concluded that these findings were consistent with the small cell variant CD30+ PCALCL, which occurs rarely.
Aged
;
Biopsy
;
Chromogranin A
;
Cytoplasm
;
Desmin
;
Eosinophils
;
Female
;
Humans
;
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic*
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell
;
Lymphoma, T-Cell, Cutaneous
;
Magnetic Resonance Imaging
;
Melanoma
;
Myoglobin
;
Neuroectodermal Tumors
;
Neuroendocrine Tumors
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S100 Proteins
;
Synaptophysin
;
Ulcer
;
Vimentin
9.Primary Cutaneous Anaplastic Large Cell Lymphoma of the Lower Lid.
Mi Rang KIM ; Jun Young CHI ; Young Hyeh KO ; Yoon Duck KIM
Journal of the Korean Ophthalmological Society 2005;46(12):2086-2090
PURPOSE: Primary cutaneous anaplastic large cell lymphoma is rarely encountered in the lower eyelids. We report a patient with primary cutaneous anaplastic large cell lymphoma arising from the lower eyelid. METHODS: A 39-year-old man presented with a relatively fast growing mass on the center of his left lower eyelid for one month. The mass did not respond to local injection of triamcinolone at a local clinic. The lesion appeared as a solitary reddish nodule with ulceration, was non-tender, round, crusted, and measured 13 mm x 11 mm x 5 mm. Well- developed superficial vessels were found on the surface of the nodule. An incisional biopsy was performed. RESULTS: Histologic examination revealed that the bulk of the infiltrate was in the papillary and reticular dermis. Tumor cells had abundant, well-defined cytoplasm and pleomorphic nuclei with multiple nucleoli. The majority of the neoplastic cells showed immunoreactivity for CD 30 (Ki-1) along the cell membrane. A histopathological diagnosis of primary cutaneous anaplastic large cell lymphoma was made. CONCLUSIONS: Most cases of primary cutaneous anaplastic large cell lymphoma arise from the body and extremities. However, since primary cutaneous anaplastic large cell lymphoma may occur in the eyelid, it should be differentiated from nodular and relatively fast growing inflammatory tumors despite local steroid treatment.
Adult
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Biopsy
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Cell Membrane
;
Cytoplasm
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Dermis
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Diagnosis
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Extremities
;
Eyelids
;
Humans
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
;
Triamcinolone
;
Ulcer
10.A Case of Mycosis Fungoides Concurrent with Lymphomatoid Papulosis.
Jae Woo CHOI ; Soon Hyo KWON ; Kkot Bora YEOM ; Sun Young HUH ; Kwang Hyun CHO ; Kye Yong SONG ; Sang Woong YOUN ; Kyoung Chan PARK ; Jung Im NA
Korean Journal of Dermatology 2011;49(10):931-935
Mycosis fungoides (MF) is the most frequent cutaneous T cell lymphoma (CTCL). Since the major tumor cell of MF is the helper T cell, positive markers are usually CD3, CD4 and CD45RO. Some MFs show CD30 positivity and the major differential diagnosis for MF with CD30 positivity includes transformed MF and MF concurrent with primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. As each disease shows a different prognosis, an exact diagnosis is crucial for proper treatment. We now report a case of 44-year-old male patient with mycosis fungoides which developed several papules on preexisting MF patches. On biopsy of the newly formed papules, CD 30 positive cells were observed and the histologic features were consistent with lymphomatoid papulosis. Both the lesions of lymphomatoid papulosis and MF responded well to narrow band ultraviolet B phototherapy.
Adult
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Biopsy
;
Diagnosis, Differential
;
Humans
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell
;
Lymphoma, T-Cell, Cutaneous
;
Lymphomatoid Papulosis
;
Male
;
Mycosis Fungoides
;
Phototherapy
;
Prognosis