Humans ; Lymphoma, B-Cell/pathology* ; Lymphoma, Non-Hodgkin/pathology*

Background: Non-Hodgkin's lymphoma is a malignant (cancerous) growth of B or T white blood cells (lymphocytes) in the lymph system. Many lymphoma classifications were proposed. All were based by groups of the original cells, histopathological appearances and clinical features. Purpose: Histological classification of lymph node malignant non - \r\n", u'Hodgkin lymphoma based on the new WHO 2001 classification. Objectives: To apply new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma were histopathologically and immunohisto chemically studied at K hospital in Hanoi. Subjects and method: The study included 165 patients with malignant non Hodgkin lymphoma were examined and treated at K hospital in Hanoi from 2000 to 2003. Results: The study based on new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma showed results B lymphoma: Diffuse large B - cell lymphoma accounts for 63.3%, follicular lymphoma: 17.5%, small lymphocytic lymphoma: 12.5%, mantle cell lymphoma: 1.7% and the others are at low rate. T lymphoma: large T-cell lymphoma accounts for 35.0%, T lymphoblastic lymphoma: 30.0%, angioimmunoblastic T-cell lymphoma: 12.5%, peripheral T- cell lymphoma, unspecified: 10.0%, the others are at low rate. Conclusion: We concluded that new WHO classification of malignant non Hodgkin is reproducible in our practice and should be useful in the treatment decision. \r\n', u'
Lymphoma ; Non-Hodgkin/ pathology ; epidemiology Neoplasms by Histologic Type

Adult ; Glottis ; pathology ; Humans ; Laryngeal Neoplasms ; pathology ; Lymphoma, Non-Hodgkin ; pathology ; Male ; Tracheal Neoplasms ; pathology

OBJECTIVETo report a case of rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma.

METHODSClinical records of a 71 years old male patient with rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma admitted on May 19, 2010 to the First Affiliated Hospital of Sun Yet-sen University were retrospectively reviewed. Clinical manifestations, diagnosis, and treatment as well as postoperative pathology were summarized.

RESULTSThe preoperative diagnosis of the patient was severe atypical adenomatous hyperplasia with focal carcinogenesis, and the preoperative staging was T2N0-1M0. The patient underwent a Parks procedure (rectal resection and colo-anal anastomosis) and subtotal resection of left lateral liver. The operation was successful, postoperative recovery uneventful. Postoperative pathology showed moderately differentiated tubular adenocarcinoma with deep muscular invasion, and non-Hodgkin lymphoma with marginal zone cell. Both the distal and proximal resection margins were negative and no vascular and neural invasion were seen. Immunohistochemical staining indicated L26(+), Bcl-2(+), Bcl-6(+), CD3(-), CD23(-), CK epithelial cells(+), and M-CEA luminal border(+). The pathological and immunohistochemistry results of liver specimens showed hepatic mucosa-associated marginal zone lymphoma.

CONCLUSIONSRectal adenocarcinoma and lymphoma occurring at the same site simultaneously is extremely rare with unique pathologic features.

Adenocarcinoma ; complications ; pathology ; Aged ; Humans ; Lymphoma, Non-Hodgkin ; complications ; pathology ; Male ; Rectal Neoplasms ; complications ; pathology

Global Health ; Hodgkin Disease ; classification ; epidemiology ; pathology ; therapy ; Humans ; Lymphoma, Non-Hodgkin ; classification ; epidemiology ; pathology ; therapy ; Risk Factors ; Singapore ; epidemiology

Adult ; Female ; Humans ; Lymphoma, Non-Hodgkin ; diagnosis ; pathology ; Tracheal Neoplasms ; diagnosis ; pathology

Adult ; Carcinoma, Hepatocellular ; secondary ; Humans ; Liver Neoplasms ; secondary ; Lymphoma, Non-Hodgkin ; pathology ; Male ; Spinal Neoplasms ; pathology

This study was purposed to investigate the clinicopathological features of acute tumor lysis syndrome (ATLS) in elderly patients with malignant non-Hodgkin's lymphoma, so as to explore its diagnosis and treatments. 2 cases of ATLS in elderly patients with non-Hodgkin's lymphoma were retrospectively analyzed, including progress of tumor, the level of laboratory examination, clinical manifestation and response to treatments. Data regarding clinical and biochemical parameters were collected. The results indicated that the 2 patients with non-Hodgkin's lymphoma were found to have high tumor burden, and were sensitive to anti-tumor treatments, and had many promoting factors of ATLS. 1 patient displayed hyperkalemia, but another displayed hypokalemia. Both patients were given allopurinol, hydration and alkalization, and one was given dialysis. But both died because of disease deterioration. ATLS rarely occurred in patients who were treated by rituximab only. But the patients with high grade NHL and high tumor burden maybe develop ATLS during 1 - 4 days after given rituximab. In conclusion, ATLS is one of factors of death in patients with malignant lymphoma. The clinical manifestation is not typical, and the diagnosis mainly depends on laboratory examination parameters. Earlier judgment, prophylaxis and effective treatment are important for improving prognosis of elderly DLBCL-NHL.
Aged ; Aged, 80 and over ; Humans ; Lymphoma, Non-Hodgkin ; pathology ; Male ; Retrospective Studies ; Tumor Lysis Syndrome ; pathology

Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells and which possess ribosomal RNA (rRNA) genes. The numbers and/or configurations of NORs have been thought to be related to cellular activities. To assess the applicability of NORs associated protein (Ag-NORs) in the field of diagnostic histopathology, a silver staining was done in paraffin sections of malignant lymphomas, tonsils and reactive lymph nodes and the numbers of Ag-NORs in the nuclei of low-grade and those of high-grade lymphomas were compared. A significant difference was found between the numbers of Ag-NORs in the nuclei of low-grade lymphoma (a mean of 1.3 per nucleus) and those of high-grade lymphomas (a mean of 4.2 to 8.3 per nucleus). The Ag-NORs were often observed in nuclei in areas where nucleoli themselves were not visible in H and E stain. It is suggested that this method would be of great value in the field of tumor histopathology.
Histological Techniques ; Humans ; Korea ; Lymphoma, Non-Hodgkin/ethnology/*pathology ; Nucleolus Organizer Region/*pathology ; *Silver ; *Staining and Labeling

Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells and which possess ribosomal RNA (rRNA) genes. The numbers and/or configurations of NORs have been thought to be related to cellular activities. To assess the applicability of NORs associated protein (Ag-NORs) in the field of diagnostic histopathology, a silver staining was done in paraffin sections of malignant lymphomas, tonsils and reactive lymph nodes and the numbers of Ag-NORs in the nuclei of low-grade and those of high-grade lymphomas were compared. A significant difference was found between the numbers of Ag-NORs in the nuclei of low-grade lymphoma (a mean of 1.3 per nucleus) and those of high-grade lymphomas (a mean of 4.2 to 8.3 per nucleus). The Ag-NORs were often observed in nuclei in areas where nucleoli themselves were not visible in H and E stain. It is suggested that this method would be of great value in the field of tumor histopathology.
Histological Techniques ; Humans ; Korea ; Lymphoma, Non-Hodgkin/ethnology/*pathology ; Nucleolus Organizer Region/*pathology ; *Silver ; *Staining and Labeling