4.Clinical manifestation of lymphoma and its significance in pathological diagnosis.
Xiao-ge ZHOU ; Jian-lan XIE ; Yan JIN ; Yuan-yuan ZHENG
Chinese Journal of Pathology 2012;41(1):57-58
Burkitt Lymphoma
;
diagnosis
;
pathology
;
Female
;
Hodgkin Disease
;
diagnosis
;
pathology
;
Humans
;
Lymphoma
;
classification
;
diagnosis
;
pathology
;
Lymphoma, Extranodal NK-T-Cell
;
diagnosis
;
pathology
;
Lymphoma, Follicular
;
diagnosis
;
pathology
;
Lymphoma, Large B-Cell, Diffuse
;
diagnosis
;
pathology
;
Male
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
diagnosis
;
pathology
6.A Case of CD7+, CD4-, CD8-, CD3-acute T cell lymphoblastic leukemia.
Hee Jin HUH ; Jung Won HUH ; Mi Yae LEE ; Woon Sup HAN ; Wha Soon CHUNG
Korean Journal of Clinical Pathology 2001;21(4):260-263
A CD7 positive acute leukemia, lacking CD4, CD8, CD3, CD13 and CD33 expression may include 4 categories; acute T-cell leukemia, mixed lineage leukemia, acute undifferentiated leukemia and CD7 positive acute myeloid leukemia. Therefore, the expression of cyCD3 or the presence of TCR gene rearrangement can make the diagnosis of acute T-cell leukemia. We report a patient with acute T-cell lymphoblastic leukemia, showing CD7+, CD4-CD8-, and CD3-expression and TCR gamma gene rearrangement.
Diagnosis
;
Genes, T-Cell Receptor
;
Genes, T-Cell Receptor gamma
;
Humans
;
Leukemia
;
Leukemia, Myeloid, Acute
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
;
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
;
T-Lymphocytes
7.Transfusion - Associated Graft - Versus - Host Disease in Patients with Acute Leukemia.
Myung Soo CHA ; Kwang Hoon LEE ; Yoo Hong MIN ; Kwang Gil LEE
Korean Journal of Dermatology 1996;34(2):345-349
Graft-versus-host disease can develop in immunosuppressed individuals who receive blood product transfusions that contain imrnunocompetent lymphocytes. We report a case of transfusion-associated graft-versus-host disease(TA-GVHD) that developed in a patient with acute lymphocytic leukemia who were undergoing therapy. The groups at risk for development of TA-GVHD, the clinical presentation and course, and methods of diagnosis are summarized. Prevention of TA-CVHD is possible by irradiation of blood products given to patients at risk, but problems remain in determining the groups that warrant such measures. We should be aware of the risk of developing TA-GVHD after routine blood transfusion, especially in areas where the population's HLA types are rather homogeneous.
Blood Transfusion
;
Diagnosis
;
Graft vs Host Disease
;
Humans
;
Leukemia*
;
Lymphocytes
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
Transplants*
9.Establishment and application of multiplex FISH in detection of the complex chromosome abnormalities in leukemia.
Meng ZHAO ; Bing CHEN ; Lu WANG ; Lan XU ; Qi CAO ; Xinying SU ; Saijuan CHEN
Chinese Journal of Medical Genetics 2002;19(5):375-378
OBJECTIVETo set up the technical system of multiplex fluorescence in situ hybridization M-FISH and to explore its application in detection of the complex chromosome abnormalities in leukemia.
METHODSThe complex chromosome abnormalities of two leukemia patients were analyzed by the combination use of classical cytogenetics, chromosome painting (CP), FISH and M-FISH.
RESULTSIn a case of acute lymphoblastic leukemia-L2, the complex karyotype: 46,XY,der(2)t(2;9),der(9)t(9;12;22) was identified by M-FISH, which was detected as 46,XY,der(9)t(9;12) by classical cytogenetics; In a case of acute monocytic leukemia-M5, the complex chromosome abnormalities: 46,XY,der(2)t(2;17), der(10)t(10;11;17), der(11)t(11;?) was revealed by M-FISH, which was confirmed by CP and FISH, and mixed lineage leukemia (MLL) gene was also found involved in this complex chromosome translocation.
CONCLUSIONM-FISH was proved to be a powerful tool to examine the complicated karyotypes and hopefully to elucidate nearly all chromosomal aberrations in leukemia and other cancers.
Chromosome Aberrations ; Humans ; In Situ Hybridization, Fluorescence ; methods ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; diagnosis ; genetics