We report a case of non-Hodgkin's lymphoma(NHL) with simultaneous involvement of both thyroid and bilateral adrenal glands. Literature review on a computerized search showed that this is an extremely rare condition. The final diagnosis of diffuse large B cell lymphoma was confirmed by biopsies of thyroid gland, enlarged cervical lymph node, and adrenal gland. The significant endocrine dysfunction of the thyroid, adrenal or other endocrine glands was absent in our case. The patient responded dramatically to three cycles of chemotherapy with no complication or endocrine dysfunction and continues to be followed.
Adrenal Gland Neoplasms/drug therapy ; Adrenal Gland Neoplasms/diagnosis+ACo- ; Aged ; Antineoplastic Agents, Combined/therapeutic use ; Biopsy, Needle ; Case Report ; Cyclophosphamide/administration +ACY- dosage ; Doxorubicin/administration +ACY- dosage ; Female ; Follow-Up Studies ; Human ; Lymphoma, Large-Cell/drug therapy ; Lymphoma, Large-Cell/diagnosis+ACo- ; Prednisolone/administration +ACY- dosage ; Thyroid Neoplasms/drug therapy ; Thyroid Neoplasms/diagnosis+ACo- ; Treatment Outcome ; Vincristine/administration +ACY- dosage

We report a case of granulocytic sarcoma presented as a recurrent breast tumor in a 42-year-old woman with no history of leukemia. The case was initially diagnosed as malignant lymphoma on a previous biopsy specimen and she refused chemotherapy. At the time of recurrence of the breast tumor, the patient showed full-blown features of leukemia. This case of rare tumor suggests that differential diagnosis should be considered when malignant lymphoma of the breast is detected.
Adult ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Breast Neoplasms/diagnosis+ACo- ; Carcinoma, Lobular/diagnosis ; Case Report ; Cell Nucleus/ultrastructure ; Diagnosis, Differential ; Diagnostic Errors+ACo- ; Female ; Human ; Leukemia, Myelocytic, Acute/pathology ; Leukemia, Myelocytic, Acute/diagnosis+ACo- ; Lymphoma, Large-Cell, Diffuse/diagnosis+ACo- ; Neoplasm Recurrence, Local/pathology

We report a case of granulocytic sarcoma presented as a recurrent breast tumor in a 42-year-old woman with no history of leukemia. The case was initially diagnosed as malignant lymphoma on a previous biopsy specimen and she refused chemotherapy. At the time of recurrence of the breast tumor, the patient showed full-blown features of leukemia. This case of rare tumor suggests that differential diagnosis should be considered when malignant lymphoma of the breast is detected.
Adult ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Breast Neoplasms/diagnosis+ACo- ; Carcinoma, Lobular/diagnosis ; Case Report ; Cell Nucleus/ultrastructure ; Diagnosis, Differential ; Diagnostic Errors+ACo- ; Female ; Human ; Leukemia, Myelocytic, Acute/pathology ; Leukemia, Myelocytic, Acute/diagnosis+ACo- ; Lymphoma, Large-Cell, Diffuse/diagnosis+ACo- ; Neoplasm Recurrence, Local/pathology