1.Comments to "Pr imary Cutaneous CD30+ Anaplastic Large Cell Lymphoma That Developed after Lymphomatoid Papulosis".
Min Soo JANG ; Jong Bin PARK ; Dong Young KANG ; Jin Seuk KANG ; Jae Woo BAEK ; Sang Tae KIM ; Kee Suck SUH ; Jae Wan GO ; Shin Han KIM ; Sang Yeop YI ; Han Kyoung CHO
Korean Journal of Dermatology 2011;49(4):392-392
No abstract available.
Lymphoma, Large-Cell, Anaplastic
2.A Case of ALK-Negative Systemic Anaplastic Large Cell Lymphoma.
Hong Seok KIM ; Seung Joo SIM ; Dae Cheol KIM ; Jae Seok KIM ; Ki Hoon SONG ; Ki Ho KIM
Annals of Dermatology 2004;16(3):125-131
No abstract available.
Lymphoma, Large-Cell, Anaplastic*
3.Comments to "Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma That Developed after Lymphomatoid Papulosis".
Min Soo JANG ; Jong Bin PARK ; Dong Young KANG ; Jin Seuk KANG ; Jae Woo BAEK ; Sang Tae KIM ; Kee Suck SUH
Korean Journal of Dermatology 2011;49(6):564-564
No abstract available.
Lymphoma, Large-Cell, Anaplastic
4.ALK-positive anaplastic large cell lymphoma with a monomorphic small-cell pattern masquerading as inflammatory gastric lesions
The Malaysian Journal of Pathology 2019;41(2):213-222
Introduction: Anaplastic lymphoma kinase-positive (ALK+) anaplastic large cell lymphoma (ALCL) with a non-common pattern can be diagnostic challenging. Pathologists can be unavoidably and unintentionally blind to non-descript tumor cells in a lymphohistiocytic- (LH) or small-cell (SC)pattern. We report a case of primary systemic ALK+ ALCL with a SC pattern that presented as secondary gastric lesions with a mixed LH and SC pattern that was masqueraded as inflammatory lesions. Case Report: A 34-year-old woman with intractable epigastric pain was referred to have repeated endoscopy with biopsy. She was found to multiple gastric erosions and nodules that were diagnosed as inflammatory lesions both endoscopically and histologically. Meanwhile, she developed an acute onset of severe back pain associated with a pathologic compression fracture in the T3 thoracic vertebral body. Imaging studies disclosed a disseminated systemic disease involving abdominopelvic lymph nodes and cervical and thoracic vertebral bodies. The needle biopsy of the pelvic lymph node disclosed diffuse proliferation of monomorphic small round cells that were diffusely positive for CD30 and ALK. A diagnosis of ALK+ ALCL with a monomorphic SC pattern was rendered. Discussion: A retrospective review of the gastric biopsies with the aid of immunohistochemistry enabled us to recognise the presence of lymphomatous infiltrates with a mixed LH and SC pattern in every piece of gastric biopsies that were repeatedly misdiagnosed as inflammatory lesions. This case illustrates a significant diagnostic pitfall of the LH- and SC-patterns in ALK+ ALCL, in which the tumour cells featuring lymphoid, plasmacytoid or histiocytoid appearance can be masqueraded as inflammatory cells.
Anaplastic large cell lymphoma
5.Leukemic manifestation of anaplastic lymphoma kinase-negative-type anaplastic large-cell lymphoma.
Jae Wook KIM ; Su Jin SHIN ; Chan Jeoung PARK
Korean Journal of Hematology 2012;47(1):6-6
No abstract available.
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic
6.Primary cutaneous anaplastic large cell lymphoma in a 73-year-old Filipino male
Juan Antonio D. Cervantes ; Eunice Kaye M. Rayos-Lopez ; Ma. Teresita G. Gabriel ; Reynaldo L. Ugalde ; Johannes F. Dayrit
Journal of the Philippine Dermatological Society 2019;28(2):55-57
Introduction:
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is an uncommonly encountered subtype
of cutaneous lymphoma under the classification of CD30-positive lymphoproliferative disorders which presents
histologically as large atypical lymphocytes with pleomorphic and anaplastic cytology that localizes to the dermis.
Although recurrent, PCALCL usually carries a good prognosis, with 5-year survival rates ranging from 85% to 95%.
Case Summary:
We report a 73-year-old elderly male who consulted at our out-patient department with a 3-year
and 6-month history of multifocal, gradually enlarging, erythematous nodules with dry, necrotic areas on the scalp,
right auricular area, left axillary area, right forearm, and right thigh, accompanied by loss of appetite and nontender
cervical, left axillary, and right inguinal lymphadenopathy. Previous skin punch biopsy and immunohistochemical
stain done by the patient’s preceding dermatologist was signed out as “suggestive” of pseudolymphoma. However,
management with intralesional corticosteroid injections provided no improvement. Skin punch biopsy done at our
institution revealed ALK negative (-) anaplastic large cell lymphoma. Patient was then referred to an oncologist,
however, the patient was lost to follow-up and succumbed to community acquired pneumonia.
Conclusion
This case highlights the importance of a thorough diagnostic assessment as recent studies indicate a
poorer prognosis of ALK (-) cases, with overall 5-year survival rates consistently below 50%.
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic
7.Prognostic Value of Leukocytosis in Systemic Anaplastic Large-Cell Lymphoma with Cutaneous Involvement.
Youngkyoung LIM ; Ji Hye PARK ; Dong Youn LEE
Annals of Dermatology 2018;30(6):721-724
No abstract available.
Leukocytosis*
;
Lymphoma, Large-Cell, Anaplastic*
8.Dermatofibroma in Patient with Relapsing Primary Cutaneous Anaplastic Large Cell Lymphoma.
Dongyun SHIN ; Do Young KIM ; Min Geol LEE ; Dae Suk KIM
Korean Journal of Dermatology 2015;53(6):482-484
No abstract available.
Histiocytoma, Benign Fibrous*
;
Humans
;
Lymphoma, Large-Cell, Anaplastic
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
9.Clinicopathological Analysis of Systemic Anaplastic Large Cell Lymphoma.
Soo Young CHUNG ; Han Suk RYU ; Jae Soo KO ; Baek Youl RYOO ; Seung Sook LEE
Korean Journal of Pathology 2006;40(6):399-405
BACKGROUND: Several studies from western countries have reported variable prognoses for patients with systemic anaplastic large cell lymphoma (ALCL) depending strongly on the expression of anaplastic lymphoma kinase (ALK). However, no prognostic significance of ALK expression in Koreans was reported in a single report regarding these patients, although the number of cases was limited in that study. METHODS: We analyzed the clinicopathological features of ALK+ ALCL and ALK- ALCL in 30 Korean patients diagnosed with primary systemic ALCL. RESULTS: ALK expression was detected in 60% of all ALCL patients (18/30), and there was no statistical significance to ALK expression in overall survival. Patients with ALK+ ALCL were younger in age and had negative bcl-2 expression; these differences were statistically significant. Tumors positive for ALK protein and granzyme B expression, and negative for bcl-2 expression with a null-cell phenotype tended to have better survival outcomes, althought this trend failed to reach statistical significance (p<0.2), probably due to the limited number of cases in this study. CONCLUSION: ALK protein expression and the absence of bcl-2 in tumor cells tend to result in better survival despite the failure of this trend to achieve statistical significance. Further studies that examine potential pathologic prognostic factors combined with the expression of ALK and apoptotic factors such as bcl-2 are needed. Additional larger-scale studies are also needed to conclude that ALK expression has no prognostic significance among Koreans.
Granzymes
;
Humans
;
Lymphoma
;
Lymphoma, Large-Cell, Anaplastic*
;
Phenotype
;
Phosphotransferases
;
Prognosis
10.CD30-Positive Anaplastic Lymphoma Kinase-Negative Systemic Anaplastic Large-Cell Lymphoma in a 9-Year-Old Boy.
Jeong Eun KIM ; Eui Hyun OH ; Young Suck RO ; Joo Yeon KO
Annals of Dermatology 2016;28(3):371-374
Anaplastic large-cell lymphoma (ALCL) is a CD30-positive T-cell/null-cell lymphoma that is clinically classified into either primary cutaneous ALCL or systemic ALCL (S-ALCL) sub-types. Because 90% of childhood S-ALCL cases are anaplastic lymphoma kinase (ALK)-positive, there is a lack of data on ALK-negative S-ALCL cases among pediatric patients. Herein, we report a rare case of ALK-negative S-ALCL in a 9-year-old Korean boy who initially presented with itchy erythematous maculopapules and an erosive nodule on the trunk area. We emphasize the need of high index of suspicion of an underlying malignant disease in the presence of refractory eczematous lesions.
Child*
;
Eczema
;
Humans
;
Lymphoma*
;
Lymphoma, Large-Cell, Anaplastic*
;
Male*
;
Phosphotransferases