2.De novo CD5- positive diffuse large B- cell lymphoma in leukemic phase with highly chromosome complex aberrations and splenic infarction: a case report and literatures review.
Kun WANG ; Jianhua ZHANG ; Chunxia DONG ; Fanggang REN ; Ruihong WU ; Jianli GUO ; Chen WANG ; Linhua YANG
Chinese Journal of Hematology 2015;36(10):887-887
7.Clinical Characteristics for Cutaneous Involvement in Diffuse Large B-Cell Lymphoma and Hemophagocytic Syndrome patients with First Presentation of Dermatomyositis.
Qiong LIU ; Yan GUAN ; Dong-Ping HUANG ; He-Sheng HE
Journal of Experimental Hematology 2021;29(1):253-258
OBJECTIVE:
To present one patient initially diagnosed with dermatomyositis(DM) who was eventually revealed to be diffuse large B-cell lymphoma(DLBCL) complicated with hemophagocytic syndrome(HPS), and to improve the understanding of the disease.
METHODS:
The clinical characteristics, diagnostic approach, treatment of the patient were retrospectively analyzed, and some related literatures were reviewed.
RESULTS:
A 52-year-old female patient suffered from muscle weakness, elevated serum creatine kinase activity, electromyography changes and characteristic skin rashes and diagnosed as DM. The patient was treated with glucocorticoid therapy and the muscle strength, skin rashes, and creatine kinas index turns into remission. Subsequently, subcutaneous nodules appeared during treatment, and the patient was confirmed as DLBCL based on pathological biopsy; And the patient was considered HPS because of presenting with repeated fever, splenomegaly, cytopenias, hypofibrinogenemia, hypertriglyceridemia, hyperferritinemia, high levels of sCD25, low NK-cell activity and hemophagocytosis in bone marrow. But the patient refused chemotherapy, and only treated with "DXM+VP-16" to control hemophagocytic syndrome, and unfortunately died due to the disease progression.
CONCLUSION
Cutaneous involvement in diffuse large B-cell lymphoma and hemophagocytic syndrome patients with first presentation of dermatomyositis is relatively rare. Malignacy screening should be performed as soon as possible after newly diagnosed DM, so that the patient can get early diagnosis and effective treatment to improve survival rate.
Dermatomyositis/complications*
;
Etoposide
;
Female
;
Humans
;
Lymphohistiocytosis, Hemophagocytic/diagnosis*
;
Lymphoma, Large B-Cell, Diffuse/complications*
;
Middle Aged
;
Retrospective Studies
9.Secondary mediastinal diffuse large B cell lymphoma after the treatment of nodular sclerosis classical Hodgkin lymphoma: a case report.
Ting-ting HAN ; Lei FAN ; Li WANG ; Ji XU ; Wei XU ; Jian-yong LI
Chinese Journal of Hematology 2013;34(8):732-732
Adult
;
Hodgkin Disease
;
complications
;
pathology
;
therapy
;
Humans
;
Lymphoma, Large B-Cell, Diffuse
;
etiology
;
pathology
;
therapy
;
Male
;
Sclerosis
10.Efficacy and prognostic analysis of relapsed/refractory diffuse large B-cell lymphoma patients with hepatitis B virus infection.
Ying FANG ; Li WANG ; Ying QIAN ; Wei Li ZHAO
Chinese Journal of Hematology 2018;39(12):1017-1020
Objective:b> To evaluate the clinical and prognostic significance of hepatitis B virus infection on patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Methods:b> A retrospective analysis was performed in 81 relapsed/refractory DLBCL cases who were treated with salvage regimens from January 2004 to November 2016. The patients were divided into two group, HBsAg positive and HBsAg negative group, and assessed the clinical features and survival time of two groups. Results:b> Twenty-four (29.6%) patients were HBsAg positive and 57(70.4%) were negative. HBsAg-positive DLBCL patients showed unique clinical features, including more younger patients (P=0.005), more advanced Ann Arbor stage (P<0.001), high-risk IPI (P=0.010), more hypohemoglobin (P=0.015), especially extra-nodal involvement (P=0.038) and recurrence (P=0.002). Overall response rate (29.2% vs 68.4%, χ(2)=10.720, P=0.001) and median overall survival time [(11.3±2.9) months vs (30.0±7.6) months, χ(2)=28.175, P<0.001] were inferior in HBsAg-positive patients, respectively. Conclusion:b> To strictly control HBV infection plays an important role on the survival and prognosis of relapsed/refractory lymphoma patients.
Antineoplastic Combined Chemotherapy Protocols
;
Hepatitis B/complications*
;
Hepatitis B virus
;
Humans
;
Lymphoma, Large B-Cell, Diffuse/complications*
;
Neoplasm Recurrence, Local
;
Prognosis
;
Retrospective Studies