2.Follicular immunoblastic lymphoma: a clinicopathologic and immunohistochemical study of a case.
Xuanqiu HE ; Lei YANG ; Yanqing DING
Journal of Southern Medical University 2013;33(6):794-797
Primary follicular immunoblastic lymphoma (FIBL) is an extremely rare lymphoma. The positive expression of CD10 suggests the lymphoma originating from germinal centers (GC) and CD138-positive expression generally indicates plasmablastic or plasmacytic differentiation. We report such a rare case in a Chinese female patient and analyze the clinicopathologic and immunohistochemical features of this disease. PET-CT examination was performed to detect signs of systemic lymph node metastasis. We also discussed the differential diagnosis of FIBL from follicular lymphoma (FL) and reactive follicular hyperplasia (RFH). As a rare variant of human follicular lymphoma, FIBL is featured by a neoplastic overgrowth of intrafollicular immunoblasts. Compared with FL, FIBL has a greater chance to evolve into diffuse large B-cell lymphoma with therefore a poorer prognosis.
Adult
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Female
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Humans
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Immunoblastic Lymphadenopathy
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pathology
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Lymphoma, Follicular
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pathology
3.Update knowledge about the classification of lymphomas.
Chinese Journal of Pathology 2013;42(9):577-579
4.Histologic evaluation of malignant lymphoma.
Chinese Journal of Pathology 2011;40(4):217-219
Dendritic Cells, Follicular
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pathology
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Diagnosis, Differential
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell
;
pathology
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Lymphoma
;
pathology
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Lymphoma, Extranodal NK-T-Cell
;
pathology
;
Lymphoma, Follicular
;
pathology
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Lymphoma, Large B-Cell, Diffuse
;
pathology
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Lymphoma, Large-Cell, Anaplastic
;
pathology
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Lymphoma, Mantle-Cell
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pathology
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Lymphoma, T-Cell, Peripheral
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pathology
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Neoplasm Invasiveness
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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pathology
5.Clinical manifestation of lymphoma and its significance in pathological diagnosis.
Xiao-ge ZHOU ; Jian-lan XIE ; Yan JIN ; Yuan-yuan ZHENG
Chinese Journal of Pathology 2012;41(1):57-58
Burkitt Lymphoma
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diagnosis
;
pathology
;
Female
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Hodgkin Disease
;
diagnosis
;
pathology
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Humans
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Lymphoma
;
classification
;
diagnosis
;
pathology
;
Lymphoma, Extranodal NK-T-Cell
;
diagnosis
;
pathology
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Lymphoma, Follicular
;
diagnosis
;
pathology
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Lymphoma, Large B-Cell, Diffuse
;
diagnosis
;
pathology
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Male
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
diagnosis
;
pathology
6.Clinical Research Advances of Duodenal-Type Follicular Lymphoma--Review.
Hong-Yi LI ; Jun-Dong ZHANG ; Xue-Chun LU
Journal of Experimental Hematology 2023;31(2):581-584
Duodenal-type follicular lymphoma (DFL) is a unique subtype of follicular lymphoma (FL), which often involves the second portion of duodenum (descending part of duodenum). Due to its specific pathological features, such as lack of follicular dendritic cells meshwork and disappearance of activation-induced cytidine deaminase expression, DFL presents an inert clinical course and is often confined to the intestinal tract. Inflammation-related biomarkers suggest that the microenvironment may play a likely role in the pathogenesis and favorable prognosis of DFL. Since patients generally have no obvious clinical symptoms and low progression rate, the treatment regimen for DFL is mainly observation and waiting (W&W) strategy. This study will review the latest research progress of epidemiology, diagnosis, treatment and prognosis of DFL in recent years.
Humans
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Lymphoma, Follicular/drug therapy*
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Duodenal Neoplasms/pathology*
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Prognosis
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Tumor Microenvironment
7.Clinicopathological analysis of 64 case of angioimmunoblastic T-cell lymphoma.
Congyou GU ; Nan LI ; Min LI ; Xuemin XUE ; Zifen GAO
Chinese Journal of Hematology 2014;35(1):24-28
OBJECTIVETo explore the clinical and pathological characteristics of angioimmunoblastic T-cell lymphoma (AITL).
METHODSSixty-four cases of AITL were retrospectively analyzed by histopathological and immunohistochemical methods.
RESULTSThere were 35 men and 29 women, the median age was 59 years (range, 25-84 ys). AITL typically presented with advanced stage, generalized lymphadenopathy, hepatosplenomegaly and systemic symptoms. Morphologically, the lymph nodes showed partial or total obliteration of the normal architecture by a polymorphic infiltration of lymphocytes, and by proliferation of follicular dendritic cells and that of high endothelial venules. Most cases contained a monoclonal T-cell population as well as clonal cytogenetic abnormalities. Immunophenotype analysis showed that neoplastic cells expressed the following markers: CXCL13 (positive rate 95.3%), PD-1 (positive rate 75.0%), CD10 (positive rate 25.0%), Bcl- 6 (positive rate 40.0%), CD2 (positive rate 96.0%), CD3 (positive rate 95.0%), CD4 (positive rate 84.0%), CD5 (positive rate 73.0%), EBER (positive rate 39.5%) and Ki-67 (average positive rate 55.0%), and frequently showed aberrant loss or reduced expression of CD7 and CD8.
CONCLUSIONThe neoplastic cells of AITL showed features of CD4+ TFH, with peculiar clinical features. Peripheral T-cell lymphomas with a follicular growth pattern may show overlapping features with focal AITL.
Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Female ; Humans ; Immunoblastic Lymphadenopathy ; diagnosis ; pathology ; Lymphoma, Follicular ; pathology ; Lymphoma, T-Cell, Peripheral ; diagnosis ; pathology ; Male ; Middle Aged ; Retrospective Studies
8.Pathogenesis of follicular lymphoma.
Pei-hong ZHANG ; Xiong-zeng ZHU
Chinese Journal of Pathology 2007;36(1):56-58
Chromosomes, Human, Pair 14
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Chromosomes, Human, Pair 18
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Dendritic Cells, Follicular
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metabolism
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pathology
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Humans
;
Lymphoma, Follicular
;
genetics
;
metabolism
;
pathology
;
Lymphoma, Large B-Cell, Diffuse
;
genetics
;
metabolism
;
pathology
;
Proto-Oncogene Proteins c-bcl-2
;
metabolism
;
Translocation, Genetic
9.Update on relation between follicular helper T cells and lymphoma.
Chinese Journal of Pathology 2013;42(9):634-637
Biomarkers, Tumor
;
metabolism
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Humans
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Immunoblastic Lymphadenopathy
;
metabolism
;
pathology
;
Lymphoma
;
genetics
;
metabolism
;
pathology
;
Lymphoma, Follicular
;
genetics
;
metabolism
;
pathology
;
Lymphoma, T-Cell, Peripheral
;
genetics
;
metabolism
;
pathology
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Signal Transduction
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Skin Neoplasms
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metabolism
;
pathology
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T-Lymphocytes, Helper-Inducer
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metabolism
;
pathology
10.Clinicopathologic Charcteristics of Korean Non - Hodgkin's Lymphomas Based on REAL Classification.
Yoon Koo KANG ; Bong Seog KIM ; Tae Won KIM ; Mon Hee RYU ; Seung Sook LEE ; Baek Yeol RYOO ; Tae You KIM ; Young Hyuck IM ; Kyoo Hyung LEE ; Jooryung HUH ; Dae Seog HEO ; Yung Jue BANG ; Chulwoo KIM ; Jung Shin LEE ; Byoung Kook KIM ; Woo Kun KIM ; Sang Hee KIM ; Noe Kveong KIM
Journal of the Korean Cancer Association 1999;31(4):641-652
PURPOSE: Non-Hodgkins lymphoma (NHL) is recognized as not a single disease but a group of diseases heterogeneous in biology and clinical characteristics. Recently, a new pathologic classification system, the REAL classification, has been introduced into the clinic. Although REAL classification has tried to define the subtypes biologically more correctly, its clinical usefulness has not been established yet. A retrospective study was performed to define the clinical characteristics of Korean NHLs according to the REAL classification and to determine its clinical usefulness. MATERIALS AND METHODS: Pathologies of NHLs managed at 3 major hospitals in Korea between 1989 and 1995 were reviewed with immunophenotyping to determine the pathologic subtypes according to REAL classification. Clinical characteristics at the presentation and treatment outcomes of the eligible patients were analyzed. To determine the differences from the NHLs in the western countries, data of Non-Hodgkins Lymphoma Classification Project (NHLCP) were also compared. RESULTS: Total 802 cases were eligible for this study. Although it was similar to NHLCP study that B-cell subtypes were the majority and diffuse large B-cell lymphoma was the most common subtype, the proportion of T-cell subtypes were much higher in our patient population than in the western population. It was because peripheral T-cell lymphomas, angiocentric lymphoma in particular, were more common and follicular lymphomas were less common in our patients. Eleven common pathologic subtypes could be classified into 3 prognostic groups. Marginal zone B-cell lymphoma and lymphoplasmacytoid lymphoma of which 5-year overall survival rate (5-yOSR) were > 80% were classified in the good prognostic group. Precursor T-lymphoblastic lymphoma was classified in the poor prognostic group because its 5-yOSR was less than 30%. The other 9 subtypes were classified in the intermediate prognostic group with S-yOSR of 30-79%. CONCLUSION: The clinical. character' tics and prognoses of Korean NHLs could be defined according to REAL classification. These information would be helpful for the clinicians in formulating treatment strategies of Korean NHLs according to REAL classification.
B-Lymphocytes
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Biology
;
Classification*
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Hodgkin Disease*
;
Humans
;
Immunophenotyping
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Korea
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Lymphoma
;
Lymphoma, B-Cell
;
Lymphoma, B-Cell, Marginal Zone
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Lymphoma, Follicular
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Lymphoma, Non-Hodgkin
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Lymphoma, T-Cell, Peripheral
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Pathology
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Prognosis
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Retrospective Studies
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Survival Rate
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T-Lymphocytes
;
Tics
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Waldenstrom Macroglobulinemia