4."Typhoidal Cells" Appear in a Woman with Hemophagocytic Syndrome Secondary To Brucellosis: A Case Report.
Wei-Qing SONG ; Xu ZHENG ; Hai-Ni LI ; Li LI ; Jiang-Shui YUAN ; Shu-Guo WANG
Chinese Medical Sciences Journal 2023;38(1):62-65
We report a case of hemophagocytic syndrome (HPS) secondary to brucellosis, in which typhoidal cells were found in bone marrow, suggesting typhoidal cells present not only in Salmonella typhi infections but also in other bacterial infections. Typhoidal cells in bone marrow can be used to quickly identify the presence of bacterial infection pending the results of bone marrow and/or blood cultures.
Female
;
Humans
;
Typhoid Fever/microbiology*
;
Lymphohistiocytosis, Hemophagocytic/etiology*
;
Brucellosis/complications*
7.Comparative Analysis of Primary and Reactivated EB Virus Infection Associated Hemophagocytic Lymphohistiocytosis.
Jiang-Hua LIU ; Wei LIU ; Yan-Ge LI
Journal of Experimental Hematology 2023;31(2):575-580
OBJECTIVE:
To compare the clinical characteristics of children with hemophagocytic lymphocytosis (HLH) associated with primary Epstein-Barr virus (EBV) infection and EBV reactivation, and explore the effects of different EBV infection status on the clinical indexes and prognosis of HLH.
METHODS:
The clinical data of 51 children with EBV associated HLH treated in Henan Children's Hospital from June 2016 to June 2021 were collected. According to the detection results of plasma EBV antibody spectrum, they were divided into EBV primary infection-associated HLH group (18 cases) and EBV reactivation-associated HLH group (33 cases). The clinical features, laboratory indexes and prognosis of the two groups were analyzed and compared.
RESULTS:
There were no significant differences in age, gender, hepatomegaly, splenomegaly, lymphadenopathy, neutrophil count in peripheral blood, hemoglobin content, platelet count, plasma EBV-DNA load, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, albumin, fibrinogen, triglyceride, ferritin, hemophagocytosis in bone marrow, NK cell activity and sCD25 between the two groups(P>0.05). The central nervous system involvement and CD4/CD8 in EBV reactivation-associated HLH group were significantly higher than those in primary infection-associated HLH group, but the total bilirubin was significantly lower than that in primary infection-associated HLH group (P<0.05). After treatment according to HLH-2004 protocol, the remission rate, 5-year OS rate and 5-year EFS rate of patients in EBV reactivation-associated HLH group were significantly lower than those in EBV primary infection-associated HLH group (P<0.05).
CONCLUSION
EBV reactivation-associated HLH is more likely to cause central nervous system involvement and the prognosis is worser than EBV primary infection-associated HLH, which requires intensive treatment.
Child
;
Humans
;
Epstein-Barr Virus Infections/complications*
;
Lymphohistiocytosis, Hemophagocytic/complications*
;
Herpesvirus 4, Human
;
Retrospective Studies
;
Prognosis
9.Hemophagocytic lymphohistiocytosis manifesting as sepsis in children: a report of 6 cases.
Xiao-Sheng HAO ; Cui-Ying WANG ; Yin-Bo CHEN
Chinese Journal of Contemporary Pediatrics 2015;17(12):1360-1362
Child
;
Child, Preschool
;
Female
;
Humans
;
Infant
;
Lymphohistiocytosis, Hemophagocytic
;
complications
;
immunology
;
Male
;
Sepsis
;
etiology
;
therapy