1.Clinical and laboratory features of acute monocytic leukemia with B lymphoproliferative disorders.
Xue-Jing CHEN ; Yan LIU ; Gui-Qing GUO ; Qing-Nian CHENG ; Bing-Cheng LIU ; Dong LIN ; Kai-Qi LIU ; Ying-Chang MI ; Jian-Xiang WANG ; Hui-Jun WANG
Chinese Journal of Hematology 2012;33(9):710-714
OBJECTIVETo identify the clinical and pathological features of acute myeloid leukemia with B lymphoproliferative disorders.
METHODSThe characteristics of 3 cases of acute monocytic leukemia with untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis were reported with literatures review.
RESULTSThe patients presented with a history of anemia, bleeding and/or fever. Acute monocytic leukemia was diagnosed by bone marrow morphology, cytochemistry and pathology studies. Immunophenotyping by flow cytometry analysis showed a significant population of absolute B-lymphocyte count of > 5×10(9)/L in a patients, similar to that of chronic lymphocytic leukemia.
CONCLUSIONSThe association of acute monocytic leukemia and untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis was a rare event. The abnormal B lymphocytes was likely to be misdiagnosis. Thus, it was important to combine several kinds of laboratory studies, especially flow cytometry to identify this rare disorder.
Aged ; B-Lymphocytes ; pathology ; Female ; Humans ; Leukemia, Monocytic, Acute ; complications ; diagnosis ; pathology ; Lymphocytosis ; complications ; diagnosis ; pathology ; Middle Aged
2.A Case of Hypersensitivity to Mosquito Bites without Peripheral Natural Killer Cell Lymphocytosis in a 6-Year-Old Korean Boy.
Han Su SEON ; Ji Hyeon ROH ; Seung Ho LEE ; Eun Kyeong KANG
Journal of Korean Medical Science 2013;28(1):164-166
Hypersensitivity to mosquito bites (HMB) is a rare disease characterized by intense skin reactions such as bulla and necrotic ulcerations at bite sites, accompanied by general symptoms such as high-grade fever and malaise occurred after mosquito bites. It has been suggested that HMB is associated with chronic Epstein-Barr virus (EBV) infection and natural killer (NK) cell leukemia/lymphoma. We describe here a Korean child who presented with 3-yr history of HMB without natural killer cell lymphocytosis. He has been ill for 6 yr with HMB. Close observation and examination for the development of lymphoproliferative status or hematologic malignant disorders is needed.
Child
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Epstein-Barr Virus Infections/complications
;
Humans
;
Hypersensitivity/*diagnosis/etiology
;
Insect Bites and Stings/*diagnosis/pathology
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Killer Cells, Natural/immunology
;
Lymphocytosis/complications/pathology
;
Male
;
Republic of Korea
;
Skin/pathology
3.A Case of Hypersensitivity to Mosquito Bite Associated with Epstein-Barr Viral Infection and Natural Killer Cell Lymphocytosis.
Eui Jung ROH ; Eun Hee CHUNG ; Young Pyo CHANG ; Na Hye MYOUNG ; Young Koo JEE ; Min SEO ; Jin Han KANG
Journal of Korean Medical Science 2010;25(2):321-323
Hypersensitivity to mosquito bites (HMB) is a disorder characterized by a necrotic skin reaction and generalized symptoms subsequent to mosquito bites. It has been suggested that HMB is associated with chronic Epstein-Barr virus (EBV) infection and natural killer cell leukemia/lymphoma. We describe here a Korean child who had HMB associated with chronic EBV infection and natural killer cell lymphocytosis. A 5-yr-old boy was suffered from necrotic skin lesions on the right ear lobe. Type A EB virus was detected from hlood cells and bone marrow biospy recognized hemophagocyrosis.
Animals
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Child, Preschool
;
Culicidae/*immunology
;
Epstein-Barr Virus Infections/complications/*diagnosis
;
Herpesvirus 4, Human/genetics/isolation & purification
;
Humans
;
Hypersensitivity/complications/*diagnosis
;
Insect Bites and Stings/complications/*immunology
;
Killer Cells, Natural/immunology/*pathology
;
Lymphocytosis/complications/*diagnosis
;
Male
;
Polymerase Chain Reaction
4.Hypersensitivity to Mosquito Bites Associated with Natural Killer Cell-derived Large Granular Lymphocyte Lymphocytosis: A Case Report in Korea.
Joo Seop CHUNG ; Ho Jin SHIN ; Eun Yup LEE ; Goon Jae CHO
The Korean Journal of Internal Medicine 2003;18(1):50-52
Hypersensitivity to mosquito bites (HMB) is characterized by intense skin reactions at bite sites. The pathogenesis of HMB might be related to clonal lymphoproliferation of Epstein-Barr virus DNA-positive natural killer (NK) cells. We report the first case of HMB possibly associated with NK cell-derived large granular lymphocyte (NK-LGL) lymphocytosis in Korea.
Adult
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Animals
;
Base Sequence
;
*Culicidae
;
Epstein-Barr Virus Infections/*complications/diagnosis
;
Humans
;
Hypersensitivity/*etiology/virology
;
Insect Bites and Stings/*complications/immunology
;
Killer Cells, Natural/*immunology/pathology
;
Korea
;
Lymphocytosis/*complications/pathology
;
Male
;
Molecular Sequence Data
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Polymerase Chain Reaction
;
Prognosis
;
Risk Assessment
5.Marked Increase of Circulating Double-Negative gammadelta T Cells in a Patient With Hydroa Vacciniforme-Like Lymphoma.
Sang Yong SHIN ; Chang Hun PARK ; Duck CHO ; Hee Jin KIM ; Sun Hee KIM
Annals of Laboratory Medicine 2016;36(3):268-270
No abstract available.
Child, Preschool
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Female
;
Flow Cytometry
;
Humans
;
Hydroa Vacciniforme/*diagnosis/pathology
;
Immunophenotyping
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Lymphocytosis/complications
;
Lymphoma/*diagnosis
;
Receptors, Antigen, T-Cell, gamma-delta/genetics/*metabolism
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STAT3 Transcription Factor/genetics/metabolism
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Sequence Analysis, DNA
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Skin/metabolism
;
T-Lymphocytes/*metabolism