The trace Alb, IgG, and IgM in urine were determined with ELISA, and urinary casts protein romposition was analysed by means of immunoenzyme stain methods, in 123 cases of primary hypertension patients. A significant high level of urine Alb and Ig were found in these patients, and a positive correlation existed between urinary trace proteins and disease severity, blood pressure and disease course. These increased proteins fell to normal level after giving treatment. Besides TH (Tamm-horsfall glycoprotein), no IgG, IgA, IgM and Alb were detected in urinary casts. These results suggested that the conbined use of both methods would be benefirial to distinguish primary hypertension from renal hypertension as well as to make early prognosis and monitor of renal function.

Umbilical needling therapy of I-Ching is a new kind of acupuncture therapy conducted by Professor Qi Yong, based on and the comprehension of Zhou Yi, and enormous clinical experiences. It has now been accepted and usedgradually. Umbilical needling treatments of various diseases are with obvious effect. There are few clinical studies on the application of this therapy alone, and it is more combined with other therapies such as acupuncture, moxibustion and Traditional Chinese Medicine (TCM) for the purpose of healing. A wide range of diseases could be traeated by the combination of umbilical needling therapy and acupuncture. Umbilical needling therapy combined with moxibustion is often used to treat gynecological diseases. Internal diseases could be traeated by the combination of umbilical needling therapy and TCM. The umbilical needling therapy still lacks of systematic research and uniformed curative effect standard, and there are some difficulties and risks in practice. Therefore, its development has limitations. Besides, there are few studies on the "preventive treatment of disease" . The future research should base on the original theory, overcome the operational difficulties and carry out systematic research.

Objective To explore the effect of preoperative behavior training and psychological support on the somatic function and negative emotions of chronic rhino-sinusitis patients after functional endoscopic sinus surgery.Methods A retrospective study was conducted in 140 chronic rhino-sinusitis patients who received functional endoscopic sinus surgery in Zhoushan Hospital from January 2017 to June 2018,and they were divided into control group and observation group according to the different intervention method,with 70 cases in each group.The control group was given routine care,and the observation group received preoperative behavior training combined with psychological support.The nursing effect of the two groups was compared.Results The scores of self-rating anxiety scale and the self-rating depression scale of the observation group after intervention were (45.06 ± 2.34) points,(49.65 ± 3.11) points,respectively,which of the control group were (52.65 ± 4.88) points,(58.66 ± 5.17) points,respectively,the differences between the two groups were statistically significant (t =8.329,9.017,all P ＜ 0.05).The scores of physical health,mental health,social adaptation,psychical health and quality of life in the observation group were (43.15 ± 3.74) points,(23.35 ± 2.31) points,(43.22 ± 2.67) points,(55.47 ± 2.72) points,(167.89 ± 9.44) points,respectively,which were higher than those in the control group,the differences between the two groupswere statistically significant (t =8.038,12.018,11.328,10.771,14.028,all P ＜ 0.05).Conclusion The application of preoperative behavior training and psychological support in functional endoscopic sinus surgery can improve chronic rhino-sinusitis patients'postoperative symptoms comfort,alleviate patients'negative mental state,and improve their quality of life,which is worthy of clinical application.

OBJECTIVE:To know the utilizatior of Shenfu injection(SFI)in our hospital,and provide reference for ratio-nal use of SFI. METHODS:In respective study,patients received SFI from the Hospital Information System(HIS)in surgery department in our hospital from Jan. 2013 to Dec. 2014 were analyzed statistically in aspects of general situation,indications, usage and dosage,course of treatment,drug combination,etc. And the incidence of ADR/ADE was monitored. RESULTS:The 1 247 surgery inpatients used SFI distributed in thyroid and galactophore department(634 cases),comprehensive minimal-ly invasive department (292 cases),gastrointestinal surgery department (250 cases),urology department (64 cases) and car-diothoracic surgery department(7 cases),including 466 male and 781 female,the ratio of male to female was 1∶1.68,aver-age age was 58.50 years;it mainly used in perioperative medication (78.11%) and treated for tumors (11.23%),treatment course concentrated on 2-7 d(71.45%),dosage mainly was 100 ml(70.01%);combination medication were mainly pantopra-zole sodium,Fructus bruceae injection,Xueshuantong for injection(lyophilized),etc. The nonstandard phenomenon was exist-ed in indications,dosage,solvent selection,medication frequency,drug combination,etc. There were no obvious ADR/ADE related to SFI. CONCLUSIONS:More attention must be paid to the irrational use of SFI in surgery clinic of our hospital,the safety of traditional Chinese medicine injection in clinical use should be correctly understood,achieve dialectical therapy and rational drug use.

Esophageal squamous cell carcinoma(ESCC) is a common malignancy in china,and TNM staging is the standard staging system for ESCC.However,in clinical practice,patients' prognosis is not always consistent with the staging.This phenomenon may be attributed from the fact that the current limitation and imperfect of the TNM staging system,and besides,another possible reason might be that some prognostic factors for ESCC other than TNM descriptors may exist.Among all the prognostic factors for ESCC,molecular biomarkers received widely concern.We searched the literatures and identified 12 molecular biomarkers that received the most concern and validated them in our single surgeon team.The results showed that only P21,COX-2 and E-cadherin were significant prognostic factors for ESCC in this series.Therefore,in the current study,we reviewed the literature regarding the prognostic significance of the above mentioned three biomarkers for clinical reference.

Objective To assess the application of ultrasonography in prenatal diagnosis of fetal choledochal cysts.Methods The clinical data of 25 fetuses,who were diagnosed as fetal choledocho cysts using ultrasonography and followed up,were retrospectively analyzed.Results Among 25 cases,24 cases were confirmed as congenital choledochal cysts after normal delivery or abortion,and 1 case of liver cyst was misdiagnosed.The 24 cases' prenatal ultrasound showed liver cystic space occupying wihich was connected to intrahepatic bile duct or gallbladder.The cysts wall was thin,and the colour Doppler flow imaging CDFI showed that blood vessels circled around the cyst.In 24 fetuses with prenatal choledochal cysts,21 were fullterm birth,3 were aborted including 1 case with other congenital abnormalities.The size of choledochal cysts was not changed in 5 cases,and was enlarged with the gestational ages in remaining 16 cases fetuses.The choledochal cysts did not affect fetal growth and development.The newborn infants with congenital choledochal cysts were treated surgically within 8 months after birth and all recovered well.Conclusion Fetal choledochal cysts have typical sonographic manifestations.Ultrasonography can be used for prenatal diagnosis of congenital choledochal cysts,which can be successfully treated by surgery early after birth.

OBJECTIVE To study the risk factors of pulmonary infection and prognosis in cerebral apoplectic patients.METHODS A retrospective survey on 497 cerebral apoplectic patients was analyzed to investigate the rate of pulmonary infection,the type and the severity of cerebral apoplexy,the underlying disease,the age,and the prognosis.RESULTS The rate of infection highly increased in the older patients with the severe diseases and many riskfactors.CONCLUSIONS Controlling the rate of pulmonary infection can help us to succeed in treating cerebral apoplexy.

Objective To investigate the association between the mutations in the ALOX5AP gene and ischemic stroke.Methods In 26 patients with acute cerebral infarction and 23 normal controls,the mononucleoside polymorphism(SNPs)in the ALOX5AP was analysised by the single strand conformation polymorphism analysis of polymerase chain reaction products(PCR-SSCP)and Sanger's dideoxy chain termination.Results The frequency of SG13S100(A/G)in the ALOX5AP gene in group of cerebrall infarction(18/26,69.2%)was significantly higher than that in normal controls(8/23,34.8%)(P

AIM:To evaluate the therapeutic effects of bisdemethoxycurcumin liposome in mice with CCl4-induced acute liver injury model and its mechanism.METHODS:40 ICR mice were randomly divided into 4 groups:control group,model group,bisdemethoxycurcumin injection group and demethoxycurcumin liposome group(n=10).The liver injury model was made by injecting CCl4 in mouse's abdomen.The activities of ALT,AST in serum,the contents of MDA in liver and the pathological changes of hepatic tissue were investigated.RESULTS:Compared with those in control group,the serum ALT,AST activities and liver MDA contents of model group were highly increased,but those in bisdemethoxycurcumin injection group and bisdemethoxycurcumin liposome group were reduced significantly.The liver lobules were ameliorated obviously too,especially in bisdemethoxycurcumin liposome group.The pharmacodynamic action of liposome was better than that of the injection.CONCLUSION:Bisdemethoxycurcumin liposome has significantly protective effects on CCl4-induced acute chemical liver injury by reducing peroxidation of lipid in endotheliocyte of the liver.

Objective To investigate the impact of leukocyte-removed priming fluid on lung function peri-CPB in infants. Methods Selected 60 infants of less than 1-year-old, with ventricular septal defect (VSD), were randomly assigned to the experimental group and the control group, the experimental group took blood leukocyte-removed priming fluid, and the control group took banked blood-derived priming fluid. Indicators of OI, PaO2/PAO2, A-aDO2 and RI were recorded at the corresponding period of cardiopulmonary bypass (pre-CPB, 2h, 6h, 12h, 24h and 48h post-CPB). Results At 2h, 6h,12h post-CPB, OI and PaO2/PAO2 of the experimental group were higher than those of the control group (P