1. Inhibitory activities of plumbagin on cell migration and invasion and inducing activity on cholangiocarcinoma cell apoptosis
Luxsana PANRIT ; Luxsana PANRIT ; Tullayakorn PLENGSURIYAKARN ; Pongsakorn MARTVISET ; Kesara NA-BANGCHANG ; Tullayakorn PLENGSURIYAKARN ; Kesara NA-BANGCHANG ; Pongsakorn MARTVISET
Asian Pacific Journal of Tropical Medicine 2018;11(7):430-435
Objective: To investigate the cytotoxic, apoptotic and inhibitory activities on cell migration and invasion of plumbagin in the human cholangiocarcinoma (CCA) cell line (CL-6) in comparison with human embryonic fibroblast cell line (OUMS). Methods: Cytotoxicity activity was evaluated using MTT assay. Inhibitory effect on cell migration and invasion were investigated using label-free real-time cell analysis and QCM ECMatrix cell invasion chamber, respectively. Apoptotic activity was evaluated using flow cytometry and CellEvent™ Caspase 3/7 assay. Results: Based on results of the cytotoxicity test in CL-6 cells, 50% inhibitory concentration (IC
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