Objective To investigate the potential association of Ghrelin(GHRL)gene polymorphisms susceptible to schizophrenia by case-control study.Methods Six hundred and thirty-four patients,six hundred and six healthy control subjects were recruited.Four SNPs rs696217,rs26802,rs27647 and rs26311 were detected by the polymerase chain reaction-based-restriction fragment length polymorphism analysis.Results No significant differences in genotype or allele frequencies of the four SNPs were observed between schizophrenic patients and healthy controls (Pvalues of genotype frequencies were 0.649,0.944,0.410,0.826;P values of allele frequencies were 0.773,0.992,0.301,0.723).However,seven haplotypes(GAAG,GAGC,GAGG,GCGC,GCGG,TAGC,TAGG)showed significant differences in frequency between schizophrenic and control groups(P values were 0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).Conclusion These data suggest that the GHRL gene may not be associated with susceptibility to schizophrenia in the Chinese Han population.However,the haplotype of GA may be the susceptive factor of schizophrenia.

Objective To explore the value of ultrasound-guided EnCor vacuum-assisted biopsy system in the diagnosis and treatment of breast lesions.Methods 54 patients with breast le-sions were conducted with minimally invasive surgery by ultrasound-guided EnCor system,and the value of diagnosis and treatment of minimally invasive surgery for breast lesions was evaluated.Re-sults All of breast lesions were removed by minimally invasive surgery.In postoperative pathologi-cal diagnosis,51 cases were benign,and 3 cases were breast cancer.No active bleeding or wound infection was observed in all patients,and subcutaneous ecchymosis was found in one case, hematoma in one case,bloody nipple discharge in one case.3 months later,there was no postopera-tive incision scar;the breast maintained the normal contour,and skin sensitivity had no change in all postoperative patients.Conclusion Ultrasound-guided EnCor vacuum-assisted biopsy system is safe and reliable,and it can be used as a preferred method for patients with resection and biopsy of breast lesions or patients with suspicious breast cancers.

Objective To explore the value of ultrasound-guided EnCor vacuum-assisted biopsy system in the diagnosis and treatment of breast lesions.Methods 54 patients with breast le-sions were conducted with minimally invasive surgery by ultrasound-guided EnCor system,and the value of diagnosis and treatment of minimally invasive surgery for breast lesions was evaluated.Re-sults All of breast lesions were removed by minimally invasive surgery.In postoperative pathologi-cal diagnosis,51 cases were benign,and 3 cases were breast cancer.No active bleeding or wound infection was observed in all patients,and subcutaneous ecchymosis was found in one case, hematoma in one case,bloody nipple discharge in one case.3 months later,there was no postopera-tive incision scar;the breast maintained the normal contour,and skin sensitivity had no change in all postoperative patients.Conclusion Ultrasound-guided EnCor vacuum-assisted biopsy system is safe and reliable,and it can be used as a preferred method for patients with resection and biopsy of breast lesions or patients with suspicious breast cancers.