Schizophrenia (SZ) stands as a severe psychiatric disorder. This study applied diffusion tensor imaging (DTI) data in conjunction with graph neural networks to distinguish SZ patients from normal controls (NCs) and showcases the superior performance of a graph neural network integrating combined fractional anisotropy and fiber number brain network features, achieving an accuracy of 73.79% in distinguishing SZ patients from NCs. Beyond mere discrimination, our study delved deeper into the advantages of utilizing white matter brain network features for identifying SZ patients through interpretable model analysis and gene expression analysis. These analyses uncovered intricate interrelationships between brain imaging markers and genetic biomarkers, providing novel insights into the neuropathological basis of SZ. In summary, our findings underscore the potential of graph neural networks applied to multimodal DTI data for enhancing SZ detection through an integrated analysis of neuroimaging and genetic features.
Humans ; Schizophrenia/pathology* ; Diffusion Tensor Imaging/methods* ; Male ; Female ; Adult ; Brain/metabolism* ; Young Adult ; Middle Aged ; White Matter/pathology* ; Gene Expression ; Nerve Net/diagnostic imaging* ; Graph Neural Networks

Objective To explore the value of ultrasound-guided EnCor vacuum-assisted biopsy system in the diagnosis and treatment of breast lesions.Methods 54 patients with breast le-sions were conducted with minimally invasive surgery by ultrasound-guided EnCor system,and the value of diagnosis and treatment of minimally invasive surgery for breast lesions was evaluated.Re-sults All of breast lesions were removed by minimally invasive surgery.In postoperative pathologi-cal diagnosis,51 cases were benign,and 3 cases were breast cancer.No active bleeding or wound infection was observed in all patients,and subcutaneous ecchymosis was found in one case, hematoma in one case,bloody nipple discharge in one case.3 months later,there was no postopera-tive incision scar;the breast maintained the normal contour,and skin sensitivity had no change in all postoperative patients.Conclusion Ultrasound-guided EnCor vacuum-assisted biopsy system is safe and reliable,and it can be used as a preferred method for patients with resection and biopsy of breast lesions or patients with suspicious breast cancers.

Objective To explore the value of ultrasound-guided EnCor vacuum-assisted biopsy system in the diagnosis and treatment of breast lesions.Methods 54 patients with breast le-sions were conducted with minimally invasive surgery by ultrasound-guided EnCor system,and the value of diagnosis and treatment of minimally invasive surgery for breast lesions was evaluated.Re-sults All of breast lesions were removed by minimally invasive surgery.In postoperative pathologi-cal diagnosis,51 cases were benign,and 3 cases were breast cancer.No active bleeding or wound infection was observed in all patients,and subcutaneous ecchymosis was found in one case, hematoma in one case,bloody nipple discharge in one case.3 months later,there was no postopera-tive incision scar;the breast maintained the normal contour,and skin sensitivity had no change in all postoperative patients.Conclusion Ultrasound-guided EnCor vacuum-assisted biopsy system is safe and reliable,and it can be used as a preferred method for patients with resection and biopsy of breast lesions or patients with suspicious breast cancers.

Objective To investigate the potential association of Ghrelin(GHRL)gene polymorphisms susceptible to schizophrenia by case-control study.Methods Six hundred and thirty-four patients,six hundred and six healthy control subjects were recruited.Four SNPs rs696217,rs26802,rs27647 and rs26311 were detected by the polymerase chain reaction-based-restriction fragment length polymorphism analysis.Results No significant differences in genotype or allele frequencies of the four SNPs were observed between schizophrenic patients and healthy controls (Pvalues of genotype frequencies were 0.649,0.944,0.410,0.826;P values of allele frequencies were 0.773,0.992,0.301,0.723).However,seven haplotypes(GAAG,GAGC,GAGG,GCGC,GCGG,TAGC,TAGG)showed significant differences in frequency between schizophrenic and control groups(P values were 0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).Conclusion These data suggest that the GHRL gene may not be associated with susceptibility to schizophrenia in the Chinese Han population.However,the haplotype of GA may be the susceptive factor of schizophrenia.