Objective: to explore the effect of non nutritive sucking combined with maternal voice stimulation on feeding process in premature infants. Methods: A total of 129 premature infants admitted to the neonatal department of a tertiary hospital from July 2016 to July 2017 were randomly selected. According to the random number table method, there were 3 groups: NNS group, control group (routine nursing group), and NNS+MSS group, each with 43 cases. Non-nutritive sucking was given in the NNS group, general routine treatment and nursing in the control group, and non-nutritive sucking combined with mother's voice stimulation in the NNS+MSS group. The duration of feeding, initial feeding and hospitalization were observed in 3 groups. Results: NNS + MSS group feeding transition time, the first feeding duration, hospitalization days three points respectively (8.60 ± 1.24)d, (8.16±1.74)min, (13.26 ± 1.84)d, and NNS group respectively (12.09 ± 2.10) d, (4.72±1.45) min, (14.70±1.79) d, the control group, respectively (17.70±2.30) d (2.28 ± 1.39) min (19.81± 4.17) d. The differences between the three groups were statistically significant (F=242.085, 159.313, 63.856, all P<0.05). Conclusions Non nutritive sucking combined with mother sound stimulation can promote early feeding from nasal feeding to complete transoral feeding as soon as possible, reduce intermediate conversion time, accelerate feeding process and shorten hospitalization time.