Objective To analyze the composition and change of the disease spectrum of inpatients in a third-level women's and Children's Hospital in Foshan City,so as to provide evidence for the prevention and treatment of common diseases among local women and children and promote the development of maternal and child health work.Methods The primary diagno-sis and other medical data of home page of inpatients from 2013 to 2022 were collected and classified according to the Internation-al Classification of Diseases(ICD-10),and the changes of age,gender and disease spectrum of hospitalized patients in different discharge year groups were compared.Results The average increase rate of patients discharged from hospital in 2022 compared with 2013 is 9%.The majority of discharged patients were female adults,accounting for 65.2%.Adult female patients are mainly hospitalized for pregnancy,childbirth and puerperium,neoplasms,and genitourinary diseases,the composition of gynecological neoplasms and genitourinary diseases increased.Most of the hospitalized children were boys,with a sex ratio of 1.9 ∶1.Respirato-rydiseases and some conditions originating in the perinatal period in the decade from 2013 to 2022 were in the top two of the dis-ease spectrum of pediatric patients,and the ranking of Symptoms,signs and anomal clinical and laboratory findings,not else-where classified and neurological diseases increased rapidly.Conclusion Pregnancy,childbirth,puerperal and other special fe-male health conditions are still the main reasons for female hospitalization.It is necessary to continue to guarantee medical re-sources and strengthen the diagnosis and treatment ability of female tumor.Children's respiratory diseases and certain conditions originating in the perinatal period are still disciplines that need to be focused,while children's neurological diseases also need to continue to focus on due to their rapid growth.

Objective To provide clues for the diagnosis standard, laboratory examination and pathological mechanism of asthma and chronic obstructive pulmonary disease overlap syndrome(ACOS) by detecting the levels of serum total IgE, fractional exhaled nitric oxide (FeNO) and peripheral blood oxyphil cells in asthma, chronic obstructive pulmonary disease (C0PO) and ACOS. Methods A prospective randomized trial based on hospital was conducted. According to the diagnostic criteria and inclusion criteria, 40 asthma patients(asthma group), 25 cases of patients with COPD(COPD group)and 37 cases of ACOS patients(ACOS group)were collected continuously, and 40 healthy persons(healthy control group) were as the research object. General data and biochemical indexes were tested in each group. The levels of serum total IgE, FeNO and peripheral blood oxyphil cells in each group were observed and compared.The correlation between serum total IgE and other biochemical parameters were analyzed by Pearson correlation analysis. Results The level of total serum IgE in asthma group was significantly higher than that in other groups(P<0.05),and the level of total serum IgE in ACOS group was the second(P<0.05).The level of total serum IgE in healthy control group and COPD group had no significant difference(P>0.05).The level of FeNO in four groups had significant difference(P<0.05), and the level of FeNO in ACOS group and asthma group had significant difference compared with that of COPD group (P < 0.05). The level of peripheral blood oxyphil cells in asthma group, ACOS group, COPD group was significantly higher than that in healthy control group (P < 0.05), and the change of ACOS group was the best obviously.Conclusions Serum total IgE, FeNO and peripheral blood oxyphil cells are specific detection index in ACOS.Combined detection can help to identify ACOS, asthma and COPD, also reveal the presence of airway inflammation in the pathogenesis of ACOS, and can provide the basis for clinical diagnosis, treatment and prevention.