OBJECTIVE:To study the occurrence of adverse drug reaction(ADR)in our hospital and its relevant factors in order to improve the rational drug use level in the clinic.METHODS:A total of 134 cases of ADR reports collected in our hospital in 2006 were classified and analyzed statistically.RESULTS:Of the 134 cases,99 kinds of drugs were involved(in different dosage forms and specifications),leading the list were anti-infectives(34 kinds,34,34%),followed by Chinese drug preparations.Intravenous infusion(94 cases/times,59.49%)was the main route of administration;and the main types of ADR were lesions of skin and accessories.CONCLUSION:Great importance should be attached to ADR monitoring to promote rational drug use in the clinic.

Objective To investigate clinical characteristics and psychological problems of patients with severe acute respiratory syndrome,and to study the effects of drug therapy and psychological intervention.Methods To analysis clinical characteristics and psychological qustioniare results.Results Fifty-one patients (male twenty-nine,female twenty-two,age range 15～68,average age (33 2?8)were analysed.Clinical symptoms were fever(96 1%),muscle pain and fatige(80 4%),cough 56 9%,chest distress and short breath(25 5%),dizziness and headeache(27 5%),diarrhea(3 9%).Psychological questionare results were depression and anxiety(90 2%),sleepless (51 2%),anorexia (31 7%),despair of disease (34 1%),restlessness (65 9%),fear unjustified attitude of other people after discharge (61 0%).Anti-viral drugs were used in 84.0% of the patients (ribavirin 0 4～1 2gram/day,clinical course 7～15 days).Antibiotics were used in 70 0% of the patients,mainly azithromycin and levofloxacin.Glucocortical steroid was used in 57 0% of the patients,mainly methylprednisolone 40～320 microgram per day with clinical course 3～15 days.Psychological intervention include such therapies as supporting,recognition,drug-assiting, suggestion, telephone talking etc.all of the patients were cured and discharged.Conclusion Comprehensive drug-therapy,especially glucocortical steroid was effective,psychological intervention was an important assisted therapy

OBJECTIVE:To provide scientific reference for prescription comment. METHODS:Network questionnaire was de-signed to investigate the development of hospital prescription comment taking hospital pharmacists from Shanghai as the object. The surveyed data were analyzed statistically. RESULTS:A total of 51 effective questionnaires were collected with effective recovery rate of 100%,involving 51 hospitals. Second-level prescription comment mode was adopted in 51 hospitals;the mode of"initial clinical pharmacist comment,expert group re-comment"was mostly adopted in second-level hospitals,accounting for 23.53%. The mode of"outpatient pharmacist initial comment,clinical pharmacist re-comment"was mostly adopted in third-level hospitals and general hospitals,accounting for 23.53% and 21.57%,respectively. The method of"all prescriptions randomly selected at one stage"was mostly adopted in third-level hospital(accounting 23.53%). 45.10% of them did not adopt information system for pre-scription comment. 86.27% of surveyed hospitals carried out the review once a month. The limitation on the amount of drugs which were"less than 2 weeks"and"less than 1 month"took up the high proportion(41.18%,45.10%). Among irrational used common drugs,antibiotics accounted for the highest proportion (43.14%). In supernormal prescriptions,the most common problem was drug use without indication(accounting for 64.71%). Surveyed pharmacists from different types of hospital had different comments on same prescription. The effects of prescription comment on hospital rational drug use and pharmacist's ability had been widely recognized,but its effects on physician prescribing behavior was not satisfactory(only 5.88% respondents believed the great effects of prescription comment). Main ideas and suggestions of surveyed pharmacists for improving the role of prescription comment were"to improve the comment ability of pharmacists","to pay more attention by hospital leaders"and"to increase the degree of infor-mation management". CONCLUSIONS:During the process of prescription comment,it is necessary to improve the authority of prescription comment and the scientific sampling method,optimize the frequency of prescription comment and the consistency of comment results,and also pay attention to combination with administrative intervention.

Objective:To analyze the status of the construction and quality of scientific research ethics committee of medical institutions of Shanghai health and family planning system,and to provide the basis for promoting the standardization of ethic review of scientific research projects.Methods:Taking the training representative of ethics committee of Shanghai health and family planning system as participant,we obtained the relevant information of scientific research ethics committee using questionnaire survey method and carried on system analysis and evaluation.Results:Since the promulgation of local standard of Shanghai scientific research ethics review,scientific research ethics committees gradually standardly conducted the ethical review work of scientific research projects and carried out ethical training programs,but there were still some shortcomings and facing challenges in the aspect of the review quality management,specific ethical issues,discipline construction and personnel training.Conclusion:Scientific research ethics committee should enhance the quality of review,discipline construction and personnel training according to local standards.