Study on 99 patients with systemic lupus erythematosus (SLE) who were diagnosed and treated at Dermatology hospital, and all patients had surveyed genotype of FC gamma RIIA. The control group consisted of 93 voluntary blood donors who were surveyed genotype of FCRIIA. Genotype of FCRIIA was defined by PCR-SSP method. Results: 4 PCR reactions were used to determine genotype of FCRIIA. The frequency of R/R131, R/H131 and H/H131 in 99 patients occurred in 15 (15.1%), 74 (74.1%) and 10 (10.1%), respectively and in 93 control persons were 11 (11.8%), 50 (53.8%) and 32 (34.4%), respectively. The distribution of frequency of 3 genotype between 2 groups was different with 2 = 16.16 and p<0.01. Genotype of FCRIIA could be the risk factors for the appearance of SLE in Vietnamese people.
Lupus Erythematosus, Systemic ; Diagnosis

Patients with systemic lupus erythematosus (SLE) diagnosed and treated at National Institute of Demato-Venereology, based on 4 criteria of SLE classifications. In control group, volunteers were taken blood samples to analyse genotypes. Study the relationship of SLE and polymorphism of FcR-coded gene, authors suggested FcRIIIB genotype may be risk factor of SLE, and FcRIIIB genotype isn’t related to occurrence of SLE.
Lupus Erythematosus, Systemic ; Diagnosis ; Therapeutics

Study on all in-patients treated at Kidney Department of Bach Mai Hospital from 2000 to 2002, which divided into 2 groups: group 1 included 38 patients with lupus nephritis and nephrotic syndrome, group 2 included 45 patients with primary nephrotic syndrome (NS). Results: most of primary NS occurred before the age of 50 years old (95.6%), there was no difference between male and female. NS due to systemic lupus erythematosus (SLE) had multiple clinical signs and was more severe than in primary NS. The prevalence of renal impairment in both primary and secondary NS was high (44.4% and 55.3%, respectively). The serum protein concentration in primary NS was significant lower than secondary NS (p<0.01). Nevertheless, serum cholesterol, HDL-C, LDL-C concentrations in primary NS were significant higher than secondary NS (p<0.01). In primary NS, the rate of minimal change glomerulonephritis was highest (51.1%), but in secondary NS, mesangial proliferative glomerulonephritis accounted for highest rate (63.2%). In type IV in secondary NS due to SLE, there were symptoms of hypertension, renal failure, hemorrhage and the histological damages were more severe than in other types (p<0.05). Histological lesions in secondary membrane and mesangial proliferative glomerulonephritis due to SLE were more severe than primary diseases.
Nephrotic Syndrome, Lupus Erythematosus, Systemic, Adult, Diagnosis

87 subjects aged 10-69 with the diagnosis of systemic erythema lupus-SLE (82.67% female) were treated in Marine Medicine Centre at Hai Phong College of Medicine and Viet Tiep Hospital. The most common age is 20-49 (65.82%). Most common clinical signs are anemia 67.82%, arthritis 65.51%, erythema 64.37%, ulcer of month 32.18%, sensitive to light 27.84%, disk shape erythema 16.09%. The rate of positive antinucleus antibody in SEL is 66.67%, anti ds DNA – 60.92% with the technique of indirect fluorescein using basal subtract as antigene Crithidia lucilae and Hep-2 cells. The value of immunological examination contributes to early diagnosis of SLE with the rate of 83.91%, helping to follow the progress of condition during the management
Lupus Erythematosus, Systemic ; diagnosis ; Therapeutics ; immunology

In order to better understand the clinical manifestation of systemic lupus erythematosus (SLE) with intracranial hypertension syndrome (IHS), we analyzed the clinical features and treatment of a typical SLE patient with IHS. SLE is one of the most unpredictable autoimmune diseases involving multiple organ systems that is defined clinically and associated with antibodies directed against cell nuclei. IHS is an uncommon manifestation of neuropsychiatric SLE (NPSLE) and is characterized by an elevated intracranial pressure, papilledema, and headache with occasional abducens nerve paresis, absence of a space-occupying lesion or ventricular enlargement, and normal cerebrospinal fluid chemical and hematological constituents. IHS has been reported in a few sporadic cases in patients with SLE worldwide, but rarely has been reported in China. In this study, a 34-year-old female SLE patient with IHS was reported and pertinent literature reviewed. The clinical presentation, image logical features, and investigatory findings were discussed.
Diagnosis, Differential ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/*etiology ; Lupus Erythematosus, Systemic/*complications ; Lupus Erythematosus, Systemic/diagnosis

OBJECTIVE: Discoid erythema is most common skin lesions in chronic cutaneous lupus erythematosus (CCLE), and patients with multiple discold lesions occasionally transform into systemic lupus erythematosus (SLE). METHOD: Four patients of CCLE with 1 or 2 another criteria for the diagnosis of SLE (incomplete/latent SLE) were identified. With these patients, we undertook prospective studies regarding the response to treatment (topical corticosteroids/antimalarials) and the course of disease over a period of 3 years. RESULTS: During the past 3 years, all of the patients continued to be stable, and only experienced minor exacervations of cutaneous and/or systemic symptoms. They showed no evidences of complete remission or developing additional criteria to determine SLE. CONCLUSION: It is suggested that incomplete/latent SLE with discold cutaneous lesions infrequently evolve to SLE, and it would appear that our cases probably have good prognosis, without or minimum systemic involvements.
Diagnosis ; Erythema ; Humans ; Lupus Erythematosus, Cutaneous* ; Lupus Erythematosus, Systemic* ; Prognosis ; Prospective Studies ; Skin

Cryptococcal meningitis is rare but, often fatal complication of systemic lupus erythematosus(SLE). It is difficult to differentiate cryptococcal meningitis from neuropsychiatric lupus due to similarity of clinical symptoms and laboratory findings of cerebrospinal fluid(CSF). Earlier diagnosis and effective antifungal therapy improve the prognosis of cryptococcal meningitis in SLE patients. We report a case of cryptococcal meningitis in a patients with SLE who had been medicated with low dose steroid.
Diagnosis ; Humans ; Lupus Erythematosus, Systemic* ; Meningitis, Cryptococcal* ; Prognosis

Pulmonary hemorrhage is a rare, but serious manifestation of systemic lupus erythematosus (SLE). In this report we describe a 13-year-old girl with pulmonary hemorrhage as the sole presenting clinical manifestation of SLE. Asymptomatic pulmonary lupus needs no treatment; however, pulmonary involvement in lupus may be life threatening, in which case prompt and aggressive treatment is mandatory. The different aspects of pulmonary lupus are demonstrated through the clinical histories of patients who suffered from pleuro-pulmonary lupus. Early diagnosis of acute pulmonary complications in systemic lupus erythematosus patients is essential to improve the chances of recovery.
Adolescent ; Early Diagnosis ; Female ; Hemoptysis* ; Hemorrhage* ; Humans ; Lupus Erythematosus, Systemic

Child ; Female ; Hemoptysis ; etiology ; Humans ; Lupus Erythematosus, Systemic ; complications ; diagnosis

Child ; Humans ; Lupus Erythematosus, Systemic ; diagnosis ; therapy ; Practice Guidelines as Topic