1.Incidental Focal Acantholytic Dyskeratosis in a Patient with Discoid Lupus Erythematosus: A Possible Role for SPCA1 in the Pathogenesis of the Disease.
Hyeong Rae KIM ; Seul Ki LIM ; Hae Eul LEE ; Myung IM ; Young LEE ; Young Joon SEO ; Jeung Hoon LEE
Annals of Dermatology 2017;29(5):655-657
No abstract available.
Humans
;
Lupus Erythematosus, Discoid*
2.Four Cases of Facial Discoid Lupus Erythematosus Successfully Treated with Topical Pimecrolimus or Tacrolimus.
Ye Won HAN ; Hyung Ok KIM ; Sung Hwan PARK ; Young Min PARK
Annals of Dermatology 2010;22(3):307-311
Discoid lupus erythematosus (DLE), which is a cutaneous form of lupus erythematosus (LE), is generally refractory to a wide range of topical or systemic therapies. Although the main treatment option for DLE is topical steroids, it is often ineffective or likely to produce long-term side effects. New drugs, including tacrolimus and pimecrolimus, have been developed to overcome the adverse effects of steroids and treat the lesions of DLE for a prolonged period. We herein report 4 cases of facial DLE successfully treated with therapeutic adjuvants, topical tacrolimus or pimecrolimus.
Lupus Erythematosus, Discoid
;
Steroids
;
Tacrolimus
3.Numerous Mucin Nodules in a Patient with Seropositive Wide Spread Discoid Lupus Erythematosus.
Kozo YONEDA ; Junko MORIUE ; Kozo NAKAI ; Toshio DEMITSU ; Tetsuya MORIUE ; Ikumi YOKOI ; Asuka MUNEHIRO ; Hiroaki DOBASHI ; Yasuo KUBOTA
Annals of Dermatology 2012;24(1):112-114
No abstract available.
Humans
;
Lupus Erythematosus, Discoid
;
Mucins
4.A Case of Linear Cutaneous Lupus Erythematosus.
Mi Yeon KIM ; Chang Nam LEE ; Hyun Jeong PARK ; Jun Young LEE ; Baik Kee CHO
Korean Journal of Dermatology 2002;40(6):671-675
"Linear cutaneous lupus erythematosus(LCLE)" is linear lesion of discoid lupus erythematosus(DLE). Eleven cases LCLE were reported in the English literature including 6 Korean children. We describe an 11-year-old girl with slightly erythematous, well-defined atrophic patches arranged in a linear configuration on the left cheek. Histologic findings were consistent with DLE though the direct immunofluorescent test was negative. Moderate improvement of the lesion was observed with use of sunscreen and topical steroid for 5 months.
Cheek
;
Child
;
Female
;
Humans
;
Lupus Erythematosus, Cutaneous*
;
Lupus Erythematosus, Discoid
5.Artificial Reproduction of Lupus Erythematosus by Provocative Phototesting.
Young Ho CHO ; Seung Kyung HANN ; Yoon Kee PARK ; Min Seok SONG ; Sungbin IM
Annals of Dermatology 1993;5(2):105-108
Sunlight is one of the well-established factors which play key roles in the induction and exacerbation of lupus erythematosus. In two patients of discoid lupus erythematosus, we have experimentally reproduced skin lesions by provocative phototesting. Both UVA (100 joules/cm²) and UVB (80 millijoules/cm²) radiation induced the skin lesions. The reproduced skin lesions were clinically and histopathologically consistent with lupus erythematosus.
Humans
;
Lupus Erythematosus, Discoid
;
Reproduction*
;
Skin
;
Sunlight
6.Topical thalidomide having good effect on refractory chronic discoid lupus erythematosus: a case report.
Chen-zhong NI ; Hui-yun SONG ; Hong-mei ZHOU
West China Journal of Stomatology 2007;25(3):306-309
Systemic thalidomide has good effect on refractory chronic discoid lupus erythematosus (CDLE) whereas topical regimen of it has not been reported previously. In this paper, a case of refractory CDLE cured with topical thalidomide in clinic was reported and the feasibility of topical therapy was reviewed.
Female
;
Humans
;
Lupus Erythematosus, Discoid
;
Thalidomide
7.A Case of Linear Lupus Panniculitis in Child.
Woo Seok CHOI ; Jee Woong KIM ; Hyun Su PARK ; Sang Jai JANG ; Jung Chul CHOI
Korean Journal of Dermatology 2006;44(11):1367-1369
Lupus panniculitis is an uncommon clinical variant of cutaneous lupus erythematosus. The cutaneous lesions of lupus panniculitis are characterized by subcutaneous nodules or plaques. The overlying skin can often appear unchanged, but may also be associated with discoid lupus erythematosus and appear erythematous, atrophic, telangiectatic or poikilodermatous. The mean age of incidence is between 30~40 years, and children are rarely affected. Furthermore, a linear distributions of the lesions has rarely been reported. We herein describe a case of 8-year-old girl with linear lupus panniculitis on the face, and propose that the possibility of this disease be considered in cases where linear subcutaneous nodular lesions occur in children or young adults.
Child*
;
Female
;
Humans
;
Incidence
;
Lupus Erythematosus, Cutaneous
;
Lupus Erythematosus, Discoid
;
Panniculitis, Lupus Erythematosus*
;
Skin
;
Young Adult
8.Squamous Cell Carcinoma on the Upper Lip of a Patient with Discoid Lupus Erythematosus.
Dong Yeon KIM ; Eun Young RHA ; Gyeol YOO ; Jin Soo LIM
Archives of Plastic Surgery 2013;40(2):155-157
No abstract available.
Carcinoma, Squamous Cell
;
Humans
;
Lip
;
Lupus Erythematosus, Discoid
10.Upper lip squamous cell carcinoma arising from discoid lupus erythematosus treated with standard wide excision
Janelle G Go ; Melanie Joy Doria-Ruiz ; Daisy King-Ismael
Journal of the Philippine Dermatological Society 2020;29(2):73-77
Introduction: Squamous cell carcinoma (SCC) is a rare complication of long-standing discoid lupus erythematosus
(DLE). The reported risk factors associated with the malignant transformation include chronic inflammation, scarring, immunosuppression, and the dysfunctional healing already evident in discoid lesions. If underdiagnosed and left untreated, this may lead to higher rates of recurrences, metastases and death.
Objective: The main objective of this article is to report the diagnosis and management of a DLE-associated SCC on the upper lip of an elderly Filipino female. A short discussion on the pathogenesis and treatment of this disease entity is also presented.ugs/topical medications, family history and accompanying systemic symptoms were reviewed and analyzed.
Case: A 78-year-old female, pawid maker, developed a rapidly growing verrucous tumor measuring 4.0 x 2.0 x 2.0 cm from a depigmented atrophic plaque located on the upper lip. Initial histopathologic findings were consistent with SCC and DLE. Considering the tumor size and the challenging anatomical location, the surgical oncology and plastic surgery team carried out a wide excision with 5 mm margin of the entire upper lip mass and surrounding plaque, followed by lip reconstruction. Biopsy findings of the excised mass were consistent with the initial findings. Three months post-operation, there was significant wound healing with no recurrences.
Conclusion: Although the incidence is rare, SCC occurring in DLE is considered to be high-risk and should warrant
early recognition and prompt treatment. In this paper, the authors also highlight the use of a standard wide excision in lieu of Mohs Microscopic Surgery as an alternative option where resources are limited.
surgical flaps
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Lupus Erythematosus, Discoid
;
Carcinoma, Squamous Cell