1.Research on training quality guarantee system of medical graduate students based on project management
Yucheng PANG ; Changjun Lü ; Luping ZHANG
Chinese Journal of Medical Education Research 2017;16(8):757-762
Aiming at the problems faced by the medical postgraduate students in the cooperative medical education and the classified training mode,combined with the characteristics of the cultivation of medical postgraduates,the article constructed the quality guarantee system of graduate education based on project management.From the three dimensions of time dimension,corpus dimension and objective dimension,the article established a model of training quality guarantee system and analyzed the four work modules:construction of project organization,standardization of whole life cycle process,control of project quality and integration of project information.In addition,the article introduced the practice of this quality guarantee system in Binzhou Medical University.
2.Detailed resume of RNA m6A demethylases.
Dandan SHEN ; Bo WANG ; Ya GAO ; Lijuan ZHAO ; Yaping BI ; Jinge ZHANG ; Ning WANG ; Huiqin KANG ; Jingru PANG ; Ying LIU ; Luping PANG ; Zhe-Sheng CHEN ; Yi-Chao ZHENG ; Hong-Min LIU
Acta Pharmaceutica Sinica B 2022;12(5):2193-2205
N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m6A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m6A demethylases have been reported, fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5.