Objective To explore the effects of comprehensive psychological nursing intervention on patients with nasopharyngeal carcinoma during radiotherapy, so as to provide references for alleviating their physical and mental pain and to improve their quality of life. Methods From July 2016 to April 2017, a total of 124 cases of nasopharyngeal carcinoma patients treated by radiotherapy from a ClassⅢGrade A hospital were recruited in the research, of which 63 cases from July to December 2016 were assigned as control group and 61 cases from January to April 2017 were assigned as intervention group. Routine nursing care was provided in the control group. On the basis of the routine nursing, individual combined with group intervention was applied in the intervention group according to the psychological and behavioral interventions before and during radiotherapy. The nursing intervention lasted from the beginning of the first radiotherapy till the end of the therapy course in both groups. By the end of the therapy, all the patients were investigated with Distress Thermometer (DT) and the short Quality of Life Scale for Nasopharyngeal Carcinoma with 13 items (QOL-NPC13). Results The scores of DT in the control group and the intervention group were (8.08±0.58) and (5.30±1.11) respectively, and the difference was statistically significant (t=19.316,P<0.001). The scores of body function, psychological spirit, social relationship, toxic side effect and the quality of life of the intervention group were all higher than those of the control group, the differences were statistically significant (Z=-4.674,-7.894,-4.755,-4.842,-8.114; P< 0.001). Conclusions Comprehensive psychological nursing intervention is helpful to relieve the psychological pain and improve the quality of life in patients with nasopharyngeal carcinoma undergoing radiotherapy.

Objective:To develop the discrimination experience questionnaire for HIV/acquired immunodeficiency syndrome(AIDS) patients and test the reliability and validity of the questionnaire.Methods:Based on the literature review and semi-structured interviews to clarify the operational definition of discrimination for HIV/AIDS and develop the item pool. The questionnaire was developed though 2 rounds Delphi consultation and a pilot test. A total of 410 HIV/AIDS patients in Shanghai Public Health Clinical Center of Fudan University from June to December 2020 were selected to investigate the questionnaire, item analysis was used to screen items. SPSS 22.0 software was used for reliability test and exploratory factor analysis, the AMOS 21.0 software was used for confirmatory factor analysis to test the reliability and validity of the questionnaire.Results:The questionnaire consisted 2 dimensions(external discrimination and internal discrimination) and 10 items. Exploratory factor analysis showed that two common factors were extracted from the frequency of discrimination and the degree of negative psychological impact of discrimination experience on patients, and the cumulative variance contribution rates were 48.367% and 55.403%, respectively. The confirmatory factor analysis on the frequency of discrimination showed that Chi square degree of freedom ratio ( χ2/ df) was 2.831, P<0.05, root mean square of approximation error (RMSEA) was 0.093, goodness of fit index (GFI) was 0.928, comparative fit index (CFI) was 0.925, incremental fit index (IFI) was 0.926; the confirmatory factor analysis on the negative psychological impact of discrimination experience on patients showed that χ2/ df was 1.740, P<0.05; RMSEA was 0.076, GFI was 0.925, CFI was 0.936, IFI was 0.938. The content validity of the questionnaire was 0.9. The Cronbach α coefficientof questionnaire was 0.811, and the test-retest coefficient was 0.862 ( P<0.01). Conclusions:The discrimination experience questionnaire for HIV/AIDS patients has good reliability and validity, and it can be used to measure the discrimination for HIV/AIDS patients.