1.Role of autologous adult stem cells in liver firbrosis
Chinese Journal of Hepatobiliary Surgery 2010;16(7):549-552
Hepatic fibrosis is a wound-healing re-sponse to all kinds of chronic liver injury, which if persistent can lead to cirrhosis. Once develops to cirrhosis, the only ef-fective therapy will be liver transplantation. In recent years,many scholars have taken all kinds of methods to try to pre-vent liver fibrosis developing to cirrhosis. As auto adult stem cell possesses multi-directional differentiation and none reject reaction advantages, it has become the study hotspot of nu-merous researches for hepatic fibrosis therapy and acquired significant progression.
6.The community prevention,therapy and rehabilitation of psychiatric patients undergoing "unlock program"
Chinese Journal of Practical Nursing 2008;24(14):1-3
Objective To discuss the effect of community prevention,therapy and rehabilitation for psychiatric patients undergoing "unlock program" and free from captivity. Methods We collected and compared the result for 71 pschiatric patients before and after free from captivity by the Brief Psychiatric Rating Scale(BPRS)and Global Assessment Scale(GAS)according to the work model of the psychiatric prevention,therapy and rehabilitation nursing program which complied with "socialization,comprehension and accessibility". Results After the unlock program the total score of BPRS and GAS greatly dropped to (22.57±3.13)and (80.67±15.57)respectively 2 years later,which were statistically different from those before the attendance of the unlock program (P<0.01). Conclusions The unlock program proved to be a novel and effective nursing program for community prevention,therapy and rehabilitation of psychiatric patients free from captivity.
7.Changes of the maxillary arch produced by different self-ligating appliance systems during the leveling and aligning phases
Journal of Practical Stomatology 2010;26(2):240-243
Objective:To evaluate the changes in the transverse dimension and the perimeters of the maxillary archs produced by 3 self-ligating appliance systems during the leveling and aligning phases. Methods: 45 patients who had class I skeletal pattern and upper arch crowding 3-6 mm were divided into 3 groups with 15 subjects in every group. The dental casts were analyzed. Results: Statistically significant increases were recorded of all dentoalveolar widths (with the exception of intermolar width measured lingually) and arch perimeters. The increase in arch perimeter showed a significant negative relationship with the individual perimeter of the maxillary arch before treatment. No significant change was found in arch depth. Conclusion: The self-ligating appliance systems produce statistically significant increases in the transverse dentoalveolar width and the perimeter of the maxillary arch during the leveling and aligning phases of treatment.
8.Experience of Dr. WANG Hui-reng in preventing and treating chronic obstructive pulmonary disease with theory of prophylactic treatment
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(02):-
Chief Physician WANG Hui-reng is one of the second batch of national prestigious TCM experts. He has been engaged in medical services over 40 years and is adept in preventing and treating the chronic obstructive pulmonary disease (COPD) under the direction of prophylactic treatment, which emphasizes the control of risky factors of COPD, striving for protecting the healthy body, preventing the transmission of the disease and the recurrence after healing.
9.Expressions of IL-6 receptor subunit gp80 and gp130 genes in bone marrow of osteoporotic rat
Chinese Journal of Endocrinology and Metabolism 2000;0(06):-
Gene expressions of interleukin-6 receptor subunit gp130 and gp80 were investigated by competitive RT-PCR in the rat model of osteoporosis. A significant increase in expressions of gp130 and gp80 was found in bone marrow of osteoporotic rat, this change may be a possible mechanism in osteoporosis due to loss of estrogen.
10.Mechanisms of chronic injury in a model of heart allograft chronic rejection
Chinese Journal of Immunology 2001;0(07):-
Objective:To study the mechanisms of chronic injury in heart allograft with chronic rejection.Methods:A model of cardiac chronic rejection in the rat based on tolerance induced through donor specific blood transfusions was used.The subpopulation and the distribution of infiltrating cells and the expression of adhesion molecule and growth factors were studied by immunohistochemistry and Northern blot analysis in the chronic rejection model.Results:Infiltrating cells were predominantly T lymphocytes and macrophages,mostly evident in the interstitial,subendocardial and perivascular areas.Allografts were demonstrated significantly elevated number of CD45+,CD4+,CD8+,TCR+,CD45RB+ cells,macrophages(ED_1) and NK cells at both 3 and 6 months compared with normal rat hearts and isografts at 3 months.Damaged areas also were observed expression of the adhesion molecules ICAM-1,LFA-1,basic fibroblast growth factor (bFGF) and transforming growth factor(TGF-?1).Northern blot analysis of total RNA,showed 5 to 6 fold upregulation of TGF-?1 mRNA in the chronic rejection model compared with normal rat hearts.Conclusion:These results suggest that T lymphocytes and macrophages play a central role in the development on chronic rejection and the increased expression of ICAM-1,LFA-1,bFGF and TGF-?1 in this model supports the involvement of these adhesion molecules and growth factors in the development of cardiac allograft vasculopaphy.