@@

Objective To investigate the relationship between the characteristic changes and prognosis of the patients with mild cognition impairment (MCI). Methods The methods of clinical memory test, word and phrase fluency test, word immediate recall and word delayed recall test were used in a three-year follow-up research with 14 patients with MCI and 18 healthy elderly individuals. Results Compared to healthy elderly subjects, the scores of the word delayed recall in the patients with MCI were significantly deterioration in the second year of follow up (P

Primary age-related tauopathy (PART) is one of neurodegenerative diseases in the very old people. PART clinically resembles Alzheimer′s disease and its definite diagnose needs pathological identification of neurofibrillary tangles with or without amyloid plaques in the brain. This article reviews the historical evolution, clinical manifestation, pathology and diagnosis of PART in order to provide new insights.

Objective To evaluate the efficacy and safty of BaileMian capsulae on treatment of insomnia in aged people. Methods 40 aged people with insomnia were randomly divided into the research group (BaileMian capsule group,n= 20) and the control group (Zaorenanshen capsule group,n=20) treated for 14 days.The clinical effects were esti- mated with SDRS before and after 1 w and 2 w treatment.Results The total SDRS scores after treatments in both groups were significantly decreased comparing with scores before treatments respectively (P

60 years old) in a community of Beijing were investigated by telephone visit, physical examination and Doppler examination. The rates of hypertension, coronary artery disease, diabetes and stroke were evaluated according to the patient whether had PAOD. Results Among 1730 people, 263 cases were diagnosed as POAD. The prevalence of hypertension, coronary heart disease, diabetes and stroke in PAOD population (59.3%,40.3%,29.3% and 22.3%) was higher than those in non-PAOD population (48.1%,32.6%,23.0%and 15.2%)( P

Objective: To study the effect of active attention with/without target counting on event-related potentials (ERPs) Method: ERPs were elicited by non-target (750 Hz, 80%) and target (2000 Hz, 20%) stimuli in an auditory oddball paradigm for 18 healthy young subjects Results:Compared to the active attention with target counting manner, P3 amplitude was significantly smaller when without target counting (P

BACKGROUND: As the second anti-Alzheimer disease drug approved by Food and Drug Administration(FDA), donepezil (Aricept) has been applied in European and American market. According to the regulation of Health Ministry of China, it needs conducting clinical trial of multiple center nationwide in order to come into Chinese market.OBJECTIVE: To evaluate the efficiency and safety of donepezil on treating mild and moderate Alzheimer disease (AD).DESIGN: Randomized, single blind and placebo control prospective study based on patients.SETTING: Neurological Department of Peking Hospital and Neurological Department of the 301 Hospital of Chinese PLA, and ect.PARTICIPANTS: Totally 188 patients with mild and moderate AD[with mini-mental state examination(MMSE) score of 10 to 24 points] from 15 big hospitals of Beijng, Shanghai and Guangzhou were conducted 12 weeks'clinical trial, among which 89 cases were of single blind and placebo control study while 99 cases were of self-controlled study. All the cases met the AD diagnostic standard of clinical neurology, linguistic dysfunction and stroke(NINCDS-ADRDA) and the 4th edition of Statistic Manual (DSM-IVR).INTERVENTIONS: Donepezil (5 rmg/tablet, ip, 5 rmg/time) or placebo with same color, shape, flavor and size with donepezil ( ip, 1 tablet/time)was taken orally for 12 consecutive weeks.MAIN OUTCOME MEASURES: MMSE, clinical dementia rating scale(CDR), activities of daily life scale(ADL), biochemical parameters, electrocardiograph(ECG) and chest x-ray were conducted once every 4 weeks before and after treatment.RESULTS: The random, single blind and placebo control study showed that the score of MMSE, CDR and ADL was greatly improved in donepezil group after 12 weeks' treatment when comparing with placebo group(P ＜ 0. 01,0.05, 0.01 ). Self-controlled study showed that the score of MMSE, CRD and ADL in donepezil group after 12 weeks' treatment increased 3.5, 0.6 and 7.1 points respectively compared with those before treatment(P ＜ 0.01,0.05, 0.01 ) . The score of MMSE was already improved in the 4th week of treatment. Among the 145 patients who took donepezil, 7 cases(4.8% )experienced side effect of mild cholinergic excitability. In the placebo group,2 of the 43 cases appeared dizziness and nausea. There was no difference between two groups( P ＞ 0.05).CONCLUSION: Donepezil can effectively treat mild and moderate AD patients and improve their cognitive functions, dementia level and daily living abilities with good tolerance and high safety.

Objectives To investigate the clinical feature of Parkinson's disease (PD) with restless leg syndrome (RLS) and the pathogenesis of RLS. Methods We conducted a cross-sectional and control study. The case group concluded 31 PD with RLS patients, meanwhile 39 PD patients were selected as the control group. Clinical history, clinical manifestations, complications and laboratory examinations were compared respectively between the two groups. Results All the RLS symptoms did not appear in RLS patients until the PD symptoms came out. Significant differences were found in complications such as swallow disturbance, constipation and illusion, when we compared the two PD groups (P ＜ 0.05 ). Compared with the PD or healthy group, the level of serum ferritin and the H-reflex latency of tibial nerve were significantly decreased in PD with RLS group ( P＜0.05). Conclusions Secondary RLS is a complication of PD.Deficiency of iron and decreased inhibition function of spinal cord may lead to the occurrence of RLS in PD patients. When their motor symptoms are serious and complications are more common, PD patients are more possible to have RLS symptoms.

ObjectiveTo investigate the neuropsychological characteristics of primary hypothyroidism.MethodSixty patients with primary hypothyroidism were enrolled and 60 euthyroid subjects with age-,gender-,and education-matched served as control.Neuropsychological parameters were determined in all the participants.ResultThe word list learning,figure recall,picture recall,verbal fluency,digit span,and trail making A and B in subclinical hypothyroid patients were impaired as compared with the control (6.0± 1.6 vs 7.6± 1.1,7.3± 1.4 vs 8.6±1.1,9.1±1.9 vs 10.0±0.1,6.7±1.4 vs 9.1±1.2,11.4±2.5 vs 13.3±1.5,11.3±2.2 vs 12.8±1.5,8.0±1.8 vs 9.2±0.8,5.0±1.6 vs 6.7±1.6,12.5±3.8 vs 15.7±2.0,61.1±32.5 vs 41.9±10.6,82.0±40.2 vs 43.2±14.5,all P＜0.05 ).Neuropsychological dysfunctions in all 11 tests were found among moderate and severe hypothyroid patients(26.2±5.0 vs 29.4±4.7,6.3±1.5 vs 6.8±1.4,8.9±2.2 vs 9.9±0.2,28.7±9.7 vs 37.0±6.0,6.4±1.1 vs 9.4±1.3,8.5±1.0 vs 9.4±0.6,11.9±3.0 vs12.9±1.7,8.1±1.8 vs 9.5±1.1,5.1±1.7 vs 6.6±1.5,11.4±2.9 vs 15.1±2.4,55.1±12.2 vs 41.0±11.6,all P＜0.05).ConclusionThe severity of cognitive impairment is accompanied with the decrease of thyroid function,it suggests that the cognitive function must depend on the normal levels of thyroid hormones.

To study the features of sporadic Creutzfeldt Jakob Disease(CJD) in China. Three cases of CJD diagnosed by clinical, electroencephalography (EEG), MRI,14 3 3 brain protein in cerebrospinal fluid (CSF),pathology and immunocytochemistry prion protein (PrP) were analysed. The average age of the onset of CJD was sixty four years.The onset was acute in all three cases. Visual and cerebellar signs appeared comparatively early besides mental and myoclonic symptoms,but signs of pyramidal damage were not obvious relatively. In all the three cases EEG showed periodic sharp wave complexes. Calcification of pallidumes was showed by CT in one case. Brain atrophy was not so obvious in three cases on MRI. One case showed increased signal surrounding both lateral ventricles of the brain on T2 weighted images. Biopsy,narked changes in the frontal lobe in one case,and in the occiptal lobe in another case were observed,with disappearance of nerve cells and extensive astroglial proliferation and spongiform state. Anti PrP immunocytochemistry had detected PrP deposits in the one biopsy,but the 14 3 3 brain protein was negative in CSF. The diagnosis of CJD was made clinically, but the 14 3 3 brain protein was suspicious one time and negative in another test. It suggested that CJD in Chinese patients may consist of the following features: 1. The onset was comparatively early in age. 2. The onset was acute. 3. Visual and cerebellar signs appeared comparatively early besides mental and myoclonic changes,but signs of pyramidal damage were not obvious relatively. 4. Brain atrophy was not remarkable. 5. Farther study with MRI should be carried out. 6. Negative 14 3 3 brain protein test could not rule out CJD.