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60 years old) in a community of Beijing were investigated by telephone visit, physical examination and Doppler examination. The rates of hypertension, coronary artery disease, diabetes and stroke were evaluated according to the patient whether had PAOD. Results Among 1730 people, 263 cases were diagnosed as POAD. The prevalence of hypertension, coronary heart disease, diabetes and stroke in PAOD population (59.3%,40.3%,29.3% and 22.3%) was higher than those in non-PAOD population (48.1%,32.6%,23.0%and 15.2%)( P

Objective: To study the effect of active attention with/without target counting on event-related potentials (ERPs) Method: ERPs were elicited by non-target (750 Hz, 80%) and target (2000 Hz, 20%) stimuli in an auditory oddball paradigm for 18 healthy young subjects Results:Compared to the active attention with target counting manner, P3 amplitude was significantly smaller when without target counting (P

Objective To investigate the relationship between the characteristic changes and prognosis of the patients with mild cognition impairment (MCI). Methods The methods of clinical memory test, word and phrase fluency test, word immediate recall and word delayed recall test were used in a three-year follow-up research with 14 patients with MCI and 18 healthy elderly individuals. Results Compared to healthy elderly subjects, the scores of the word delayed recall in the patients with MCI were significantly deterioration in the second year of follow up (P

Objective To evaluate the efficacy and safty of BaileMian capsulae on treatment of insomnia in aged people. Methods 40 aged people with insomnia were randomly divided into the research group (BaileMian capsule group,n= 20) and the control group (Zaorenanshen capsule group,n=20) treated for 14 days.The clinical effects were esti- mated with SDRS before and after 1 w and 2 w treatment.Results The total SDRS scores after treatments in both groups were significantly decreased comparing with scores before treatments respectively (P

Primary age-related tauopathy (PART) is one of neurodegenerative diseases in the very old people. PART clinically resembles Alzheimer′s disease and its definite diagnose needs pathological identification of neurofibrillary tangles with or without amyloid plaques in the brain. This article reviews the historical evolution, clinical manifestation, pathology and diagnosis of PART in order to provide new insights.

Objective To identify high?risk groups of Charcot foot( CN) in the people with diabetic foot neuropathic ulcerations( NU) . Methods Twenty cases patients with CN who were diagnosed in General Hospital of the Chinese People Air Force from June 2008 to June 2013 and 58 patients with diabetic neuropathic ulcer who were hospitalized from January 2010 to December 2011 and followed up until June 2014 without foot deform?ity were retrospectively analyzed. All patient's general condition, examination and laboratory results, diabetic chronic complications,complication,diabetes distribution of foot ulcers,and plain features. Results There were no statistically significant differences in terms of patients' average age, sex ratio, proportion of smokers, BMI, HbA1c,blood lipid,dorsalis pedis artery diameter and diabetic nephropathy (Ⅲ?Ⅳperiod) ,chronic kidney dis?ease stage 3 above,proliferation diabetic retinal pathological changes,the prevalence of coronary heart disease between the two groups(P>0. 05). Compared with NU group,patients with single high proportion(40. 00%(8/20) vs. 10. 34%(6/58)),Short duration of diabetes((12. 37±5. 64) years vs. (14. 27±8. 04) years),Feet long numbness(6(5,9) years vs. 4(2,20) years),low rate of hardening of the arteries narrow(ABI<0. 9)( 0 ( 0/20) vs. 39. 66%( 13/58) ) ,high recurrent diabetic foot ulcer prevalence( 70. 00%( 14/20) vs. 25. 86%( 15/58)),more patients with diabetes mellitus autonomic neuropathy(75. 00%(15/20) vs. 39. 66%(23/58)),less combined with hypertension ( 25. 00%( 5/20 ) vs. 58. 62%( 34/58 ) ) , the differences were significant ( t orχ2=6. 981,2. 259,4. 068,3. 887,12. 405,7. 436,6. 724;P<0. 05) . Diabetic foot wound distribution on mesopodi?um of CN group and NU group was 36. 84%(7/19),6. 90%(4/58) respectively,the difference was significant (χ2=11. 443,P=0. 003) . Diabetic foot amputation rate( Wanger 4,5 grade) of CN group and NU group was 44. 44%(4/9),6. 90%(2/29) respectively,the difference was significant(χ2=4. 732,P=0. 020). Conclusion The characteristics of high?risk groups of diabetics Charcot foot in the people with diabetic foot neuropathic ulcerations are middle aged,no foot of ischemia,combine the diabetic autonomic neuropathy and the feet always with recurrent ulcers.

Objective To study the relationship among Alzheimer-like neuropathologic changes and their relationship with age and sex. Methods From January 1,1986 to April 1,2000,all autopsy caus of non-demented individuals ≥40 years of age in the General Hospital of PLA were examined for Alzheimer-like neuropathologic changes in hippocampus.There were 41 female and 97 male. Senile plaques(SP),neurofibrillary tangles(NFT) were identified with modified Palmgren-stain method. Hirano bodies(HB) or granulovacuolar degeneration(GVD) were identified with HE stain methods. Results About 40% patients had Alzheimer-like neuropathological changes in hippocampus. There was a highly significant correlation was found between the incidence and severity of SP?NFT?Hirano or GVD and patients' age in the CA1 field of the hippocampus, but no significant difference between male and female. There was a strong correlation among the prevalence and numerical densities of these four types of Alzheimer-like changes. Conclusions Alzheimer-like neuropathologic changes were mainly distributed in CA1 of hippocampus. In CA1 they had relationship with age, but no relationship with sex and they had correlation each other.

Objective To explore the clinical features of spongiform encephalopathies occurred in the elderly and causes of misdiagnosis. Methods Clinicopathological diagnosis of a 79 year old man with acute spongiform encephalopathy was reported. Clinical, EEG and MRI characteristics of eight old patients with spongiform encephalopathy in China confirmed by neuropathology were reviewed. Results Elder patients with spongiform encephalopathies had an acute onset and a rapid developing course, and all patients presented with progressive dementia accompanied by various clinical manisfestations of extrapyramidal diseases. EEG recordings with typical periodic sharp wave complexes (PSP) was shown in six cases, and abnormal T2 signal in both basal ganglia by MRI in one case. Three cases were misdiagnosed as cerebral vascular disease and one cse as encephalitis herpes cimplex. Conclusions Spongiform encephalopathy in the elderly should be paid more attention to since their early clinical symptoms are similar to that of the acute cerebral vascular diseases. It is suggested that early diagnosis of spongiform encephalopathy could be made basing on the combination of the typical clinical characteristics and dynamic EEG findings, and brain biopsy if necessary, to avoid nosocomial spreading.

Objective To investigate the glucose metabolism changes of cerebral ischemic area after middle cerebral artery occlusion (MCAO) in cat on 18 *"FDG-PET scans.Methods A permanent focal cerebral ischemia model of cat was established by electrocoagulating the terminal of left middle cerebral artery via a transorbital approach. 15 minutes before MCAO, 0.5 mCi 18 *"FDG were intravenous bolus injection.15 minutes, 1 h, 3 h, and 6 h after ischemia, 18 *"FDG-PET were performed and the SUV were measured. After neurological examination, the cats were killed for performing TTC stainnig.Results The SUV of ischemic area were highter than that of contralateral and control area(P