1.Case report: pulmonary typical carcinoid with multi-organ metastasis.
Qi GUI ; Chengcheng XU ; Shiying YU
Chinese Journal of Lung Cancer 2010;13(5):554-556
Adult
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Carcinoid Tumor
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pathology
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secondary
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Female
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Humans
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Lung Neoplasms
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pathology
2.Research progress on clinical diagnosis for lung metastases from differentiated thyroid carcinoma.
Huanhuan LI ; Suping LI ; Jinhui YOU
Journal of Biomedical Engineering 2014;31(4):950-954
Lung metastases are more common in metastatic disease in differentiated thyroid carcinoma (DTC). Because of its insidious onset and slow development, clinical diagnosis is relatively difficult. Some possible diagnostic methods for detecting the lung metastasis of DTC including serological examination, radionuclide imaging and other medical imaging patterns are discussed in this paper. The progress and the current situation about investigation of those modalities which are in the early diagnosis, recurrent and clinical evaluation for the lung metastasis of DTC are briefly reviewed. Therefore, it is expected to promote DTC with lung metastasis to a higher diagnostic level.
Humans
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Lung Neoplasms
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diagnosis
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secondary
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Neoplasm Metastasis
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Thyroid Neoplasms
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pathology
4.Skip metastasis of prostate cancer: diagnosis and treatment.
Jun-Qi WANG ; Wang LI ; Qiang WANG ; Kun LIU ; Li-Jun MAO ; Jia-Cun CHEN ; Jun-Nian ZHENG ; Xiao-Qing SUN
National Journal of Andrology 2009;15(12):1120-1123
OBJECTIVETo improve the diagnosis and treatment of far advanced prostate cancer without clinically detectable bone metastasis.
METHODSCancer metastatic lesions were found in the liver and lungs respectively of two patients on routine medical examination, and only an abnormally elevated level of the serum prostate specific antigen (PSA) was observed in the following system examinations. The patients were diagnosed as having prostate cancer by prostate biopsy. MRI showed a discontinued prostate capsule, and ECT revealed no bone metastasis. Diagnostic treatment was conducted by giving LHRHa combined with antiandrogens. One of the patients underwent surgical castration at 12 months, and both received intensity modulated radiation therapy (80 Gy) at 15 and 18 months, respectively.
RESULTSThe metastatic lesions in the liver and lungs of the patients were either absent or significantly reduced after treated by maximal androgen blockade for 3 months, and all disappeared after 6 months'treatment, with the PSA level stabilized at less than 0.02 microg/L in one patient, and around 0.5 microg/L in the other. Antiandrogen treatment was suspended after radiotherapy. The results of liver, lung and bone scanning were normal during the 12-month follow-up, and the PSA level was below 1.0 microg/L.
CONCLUSIONRemote metastasis of prostate cancer may occur in ectosteal organs first, which deserves special attention. A combination of different treatment methods promises satisfactory results.
Aged ; Humans ; Liver Neoplasms ; secondary ; Lung Neoplasms ; secondary ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms ; diagnosis ; pathology ; therapy
5.Huge hepatic angiosarcoma with spine, pelvis, spleen and pulmonary metastases: a case report.
Zhengju XU ; Xingnan PAN ; Huanwen YNAG
Chinese Journal of Hepatology 2014;22(4):311-311
Hemangiosarcoma
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pathology
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Humans
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Liver Neoplasms
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pathology
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Lung Neoplasms
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secondary
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Male
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Middle Aged
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Pelvic Neoplasms
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secondary
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Spinal Neoplasms
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secondary
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Splenic Neoplasms
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secondary
6.Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast.
Yan-Hong GAO ; Hui-Juan XIANG ; Jian ZHU ; Yun DUAN ; Pei ZHOU
Chinese Medical Journal 2018;131(6):751-752
Breast Neoplasms
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pathology
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Female
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Humans
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Lung Neoplasms
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secondary
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Phyllodes Tumor
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secondary
7.Metastatic involvement of the stomach secondary to lung carcinoma.
Hyun Soo KIM ; Woo Ick JANG ; Hee Seung HONG ; Chong In LEE ; Dong Ki LEE ; Suk Joong YONG ; Kye Chul SHIN ; Young Hak SHIM
Journal of Korean Medical Science 1993;8(1):24-29
Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of the stomach secondary to lung carcinoma were diagnosed by gastroscopy. The first patient was a 66-year-old man who had primary lung carcinoma with multiple bone and subcutaneous metastases. Gastroscopy showed multiple submucosal tumors with central umbilications in the fundus and in the upper body of the stomach. Pathologic examination revealed massive submucosal infiltration and conical shaped and scanty deep mucosal infiltration of undifferentiated small cell carcinoma suggestive of metastatic involvement. The second patient was a 68-year-old man who had primary lung carcinoma with brain metastasis. Gastroscopy showed a large fungating mass in the greater curvature side of the stomach. Pathologic examination revealed poorly differentiated squamous cell carcinoma. We report the two cases of metastatic gastric cancer from lung carcinoma with the literature review.
Aged
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Carcinoma, Small Cell/*secondary
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Carcinoma, Squamous Cell/*secondary
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Humans
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Lung Neoplasms/*pathology
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Male
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Stomach Neoplasms/*secondary
8.Clinicopathologic characteristics of metastatic carcinomas to spleen.
Chong-qing YANG ; Zi-cheng ZHANG ; Qi YU ; Jian-xin PANG
Chinese Journal of Pathology 2006;35(5):281-284
OBJECTIVETo study the clinicopathologic characteristics of metastatic carcinomas to the spleen.
METHODSSixteen cases of metastatic carcinoma to the spleen were retrieved from archival clinical, surgical pathology and autopsy records. The demographic data (including sex and age of patients), clinical symptoms, primary sites, tumor histologic types, gross appearance of spleen and growth patterns within the spleen were analyzed.
RESULTSAmong the 16 patients studied, 12 were males and 4 were females. The male predilection was obvious. The age ranged from 48 to 90 years, the median age 66.5 years. Major clinical symptoms included discomfort in the left upper quadrant, pain, emaciation and loss of appetite. Splenomegaly was noted in some patients and computerized tomography could show space-occupying lesions in the spleen. In general, lung was the most common primary site for splenic metastasis and accounted for 43.8% of all cases (7/16). In male patients, primary lung tumor was found in 50.0% cases (6/12). On the other hand, primary ovarian tumor was commonly seen in females (2/4). Histologically, undifferentiated carcinoma of lung was frequently encountered (25.0%, 4/16), including 3 cases of small cell undifferentiated carcinoma and 1 case of large cell undifferentiated carcinoma. Other histologic tumor types included bronchioloalveolar carcinoma (2 cases), colonic adenocarcinoma (2 cases), ovarian serous papillary adenocarcinoma (2 cases), and prostatic adenocarcinoma (2 cases). The commonest histologic tumor type found in male patients was pulmonary undifferentiated carcinoma. The growth patterns of metastatic carcinoma in spleen included nodular, diffuse and multinodular. Most cases presented as a single splenic nodule. Sometimes, tumors with high metastatic potential (5/16) showed diffuse and multinodular growth patterns. Examples of these tumors included small cell undifferentiated carcinoma (3 cases), pulmonary adenocarcinoma (1 case) and prostatic adenocarcinoma (1 case).
CONCLUSIONSMetastatic carcinoma to the spleen is rare. Understanding of the clinicopathologic characteristics is helpful in guiding clinical management and pathologic diagnosis.
Adenocarcinoma ; secondary ; Adenocarcinoma, Bronchiolo-Alveolar ; secondary ; Aged ; Aged, 80 and over ; Carcinoma, Small Cell ; secondary ; Colonic Neoplasms ; pathology ; Cystadenocarcinoma, Serous ; secondary ; Female ; Humans ; Lung Neoplasms ; pathology ; Male ; Middle Aged ; Ovarian Neoplasms ; pathology ; Prostatic Neoplasms ; pathology ; Spleen ; pathology ; Splenic Neoplasms ; secondary
9.A case of hepatic epithelioid hemangioendothelioma that caused extrahepatic metastases without intrahepatic recurrence after hepatic resection.
Soung Won JEONG ; Hyun Young WOO ; Chan Ran YOU ; Won Hang HUH ; Si Hyun BAE ; Jong Young CHOI ; Seung Kew YOON ; Chan Kwon JUNG ; Eun Sun JUNG
The Korean Journal of Hepatology 2008;14(4):525-531
Epithelioid hemangioendothelioma is a neoplasm of vascular origin with a low-to-intermediate malignant potential and is one of the rare sarcomas arising from the liver. Its etiology is unknown and its clinical outcome is unpredictable. There is no generally accepted therapeutic strategy because of its rarity and the variable natural course between hemangioma and angiosarcoma. We report a case of a 64-year old woman who underwent hepatic resection due to epithelioid hemangioendothelioma in the right lobe that progressed to extrahepatic metastases of the bone, pleura, and peritoneum 22 months later. However, after resection there was no primary hepatic recurrence.
Bone Neoplasms/diagnosis/pathology/secondary
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Female
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Hemangioendothelioma, Epithelioid/*diagnosis/pathology/*secondary
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Hepatectomy
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Humans
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Liver Neoplasms/*diagnosis/pathology
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Lung Neoplasms/diagnosis/pathology/secondary
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Middle Aged
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Tomography, X-Ray Computed
10.Pulmonary Metastases of Uterine Endometrial Stromal Sarcoma: Diffuse Micronodular and Ground Glass Opacities: A Case Report.
Gou Young KIM ; Chang Ohk SUNG ; Joungho HAN ; Joon Oh PARK ; Kyung Soo LEE
Journal of Korean Medical Science 2004;19(6):901-903
Pulmonary metastases of uterine endometrial stromal sarcoma (ESS) are un com-mon. The patterns of uterine ESS metastasis to the lung are multiple pulmonary nodules, single nodule, or cystic lesions. Pulmonary intraalveolar micronodular metastases of uterine ESS are unusual and have not been reported. We experienced a case of metastatic uterine ESS presenting as pulmonary diffuse micronodules with ground glass opacities on chest computed tomography of a 37-yr-old woman who previously underwent hysterectomy due to low grade ESS of the uterus four years ago. The histologic findings of video assisted thoracotomy biopsy showed numerous intraalveolar polypoid micronodules protruding from the alveolar septums. All tumor nodules were composed of short spindle cells arranged in ill-defined whorls, and nuclear feature and sparse cytoplasm were seen in uterine ESS. Immunohistochemically, these cells showed strong nuclear staining for estrogen receptor and progesterone receptor, and diffuse cytoplasmic staining for CD10.
Adult
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Endometrial Neoplasms/*pathology/radiography
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Female
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Humans
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Lung Neoplasms/*pathology/radiography/*secondary
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Sarcoma, Endometrial Stromal/*pathology/radiography/*secondary