2.Relationship between Bacteria in the Lower Respiratory Tract/Lung Cancer and the Development of Lung Cancer as well as Its Clinical Application.
Bowen LI ; Zhicheng HUANG ; Yadong WANG ; Jianchao XUE ; Yankai XIA ; Yuan XU ; Huaxia YANG ; Naixin LIANG ; Shanqing LI
Chinese Journal of Lung Cancer 2024;26(12):950-956
Due to the advancement of 16S rRNA sequencing technology, the lower respiratory tract microbiota, which was considered non-existent, has been revealed. The correlation between these microorganisms and diseases such as tumor has been a hot topic in recent years. As the bacteria in the surrounding can infiltrate the tumors, researchers have also begun to pay attention to the biological behavior of tumor bacteria and their interaction with tumors. In this review, we present the characteristic of the lower respiratory tract bacteria and summarize recent research findings on the relationship between these microbiota and lung cancer. On top of that, we also summarize the basic feature of bacteria in tumors and focus on the characteristic of the bacteria in lung cancer. The relationship between bacteria in lung cancer and tumor development is also been discussed. Finally, we review the potential clinical applications of bacterial communities in the lower respiratory tract and lung cancer, and summarize key points of sample collection, sequencing, and contamination control, hoping to provide new ideas for the screening and treatment of tumors.
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Humans
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Lung Neoplasms
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RNA, Ribosomal, 16S/genetics*
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Bacteria/genetics*
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Microbiota
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Respiratory System
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Lung/microbiology*
3.The Value of Routinely Culturing for Tuberculosis During Bronchoscopies in an Intermediate Tuberculosis-Burden Country.
Myung Hoon KIM ; Gee Young SUH ; Man Pyo CHUNG ; Hojoong KIM ; O Jung KWON ; Jang Ho LEE ; Nam Yong LEE ; Won Jung KOH
Yonsei Medical Journal 2007;48(6):969-972
PURPOSE: Many medical centers routinely culture bronchoscopy samples for Mycobacterium tuberculosis, even when tuberculosis is not strongly suspected. The value of this practice, however, is controversial. We evaluated the role of that procedure in the diagnosis of pulmonary tuberculosis in an intermediate tuberculosis-burden country. PATIENTS AND METHODS: A prospective, observational study was conducted in a tertiary referral center and included 733 consecutive patients who underwent bronchoscopy examination. RESULTS: M. tuberculosis was isolated in 47 patients (6.4%). According to radiographic features, the rate of positive culture for M. tuberculosis was relatively high in patients with atelectasis (5/33, 15.2%) and those with pulmonary infiltrations of suspicious infections (26/183, 14.2%). M. tuberculosis was isolated even in patients with pulmonary masses (9/266, 3.4%) and those with pulmonary nodules (5/175, 2.9%). In 16/47 (34.0%) patients with positive cultures for M. tuberculosis, active pulmonary tuberculosis was not suspected at the time of bronchoscopy. CONCLUSION: These results suggest that routinely culturing for M. tuberculosis during bronchoscopy is still useful in the diagnosis of pulmonary tuberculosis in an intermediate tuberculosis-burden country.
Adult
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Aged
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Bacteriological Techniques/methods
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Bronchoscopy
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Female
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Humans
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Lung/microbiology/pathology
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Lung Neoplasms/microbiology
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Male
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Middle Aged
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Mycobacterium tuberculosis/growth & development/*isolation & purification
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Prospective Studies
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Pulmonary Atelectasis/microbiology
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Reproducibility of Results
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Sensitivity and Specificity
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Tuberculosis, Pulmonary/*diagnosis/microbiology
4.Helicobacter Pylori Infection and Lung Cancer: New Insights and Future Challenges.
Ileana GONZÁLEZ ; Paulina ARAYA ; Armando ROJAS
Chinese Journal of Lung Cancer 2018;21(9):658-662
Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori has very high rates of infection in human populations, and it is estimated that over 50% of the world population is infected. Recently, certain extra-gastric manifestations, linked to H. pylori infection, have been widely investigated. Noteworthy, a growing body of evidences supports an association between H. pylori infection with lung cancer. The present review intend to highlight not only the most recent evidences supporting this association, but also some missed points, which must be considered to validate this emerging association.
Helicobacter Infections
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complications
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Helicobacter pylori
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physiology
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Humans
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Lung Neoplasms
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complications
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microbiology
5.Concomitant early avascular necrosis of the femoral head and acute bacterial arthritis by enteric Gram-negative bacilli in four oncologic patients.
Singapore medical journal 2013;54(5):e108-12
We present four cases of concomitant early (modified Ficat-Arlet stage I) avascular necrosis of the femoral head and acute bacterial arthritis of the hip joint by Gram-negative enteric bacilli. This was found in immunosuppressed oncologic patients whose clinical presentations and radiological findings were not entirely specific for joint sepsis. It is important to recognise the coexistence of these two pathologies, so as to avoid a delay in diagnosis and prevent significant morbidity and mortality.
Acute Disease
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Adenocarcinoma
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complications
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microbiology
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Adult
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Arthritis, Infectious
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complications
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diagnosis
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Bacillus
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isolation & purification
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Contrast Media
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Female
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Femur Head Necrosis
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complications
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diagnosis
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Gram-Negative Bacteria
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isolation & purification
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Hodgkin Disease
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complications
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microbiology
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Humans
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Leukemia, Myeloid, Acute
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complications
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microbiology
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Lung Neoplasms
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complications
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microbiology
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Male
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Middle Aged
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Multiple Myeloma
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complications
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microbiology
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Neoplasms
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complications
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microbiology
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Risk Factors
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Young Adult
6.Coal worker's pneumoconiosis complicated with lung cancer patients with respiratory tract of drug resistance of Pseudomonas aeruginosa.
Ji-Zhong CHEN ; Fu-Ping JIN ; He-Hong FAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(7):548-550
Adult
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Aged
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Aged, 80 and over
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Anthracosis
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complications
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microbiology
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Anti-Bacterial Agents
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pharmacology
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Drug Resistance, Bacterial
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Humans
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Lung Neoplasms
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complications
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microbiology
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Male
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Middle Aged
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Pseudomonas Infections
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microbiology
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Pseudomonas aeruginosa
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drug effects
7.Pulmonary Actinomycosis Imitating Lung Cancer on ¹⁸F-FDG PET/CT: A Case Report and Literature Review.
Lin QIU ; Lianjun LAN ; Yue FENG ; Zhanwen HUANG ; Yue CHEN
Korean Journal of Radiology 2015;16(6):1262-1265
Here we report a case of 41-year-old man with a soft tissue density mass at right upper lung and palpable abscesses at right upper backside and right wrist. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography demonstrated a 7.8 × 5.0 cm mass with soft-tissue density in the upper lobe of the right lung with high metabolic activity. The infiltrative mass extended to adjacent chest wall soft tissue. Final diagnosis of pulmonary actinomycosis with multiple abscesses was made. The patient responded well to antibiotics treatment.
Abscess
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Actinomycosis/*diagnosis/drug therapy/microbiology
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Adult
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Anti-Bacterial Agents/therapeutic use
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Diagnosis, Differential
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Fluorodeoxyglucose F18/chemistry
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Humans
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Lung Diseases/*diagnosis/drug therapy/microbiology
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Lung Neoplasms/pathology
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Male
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*Positron-Emission Tomography
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Tomography, X-Ray Computed
8.Clinical analysis of Staphylococcus aureus resistance to methicillin in patients with coal worker's pneumoconiosis complicated by lung cancer.
Si-hai LIU ; Pei-yue LIU ; Wen FENG ; Jun-he DAI ; Cheng-dong QI ; Fang QIAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(5):391-392
9.Foreign body-induced Actinomycosis Mimicking Bronchogenic Carcinoma.
Young Shin KIM ; Ju Hyun SUH ; Seung Min KWAK ; Jeong Seon RYU ; Chul Ho CHO ; Chan Sup PARK ; Soo Kee MIN
The Korean Journal of Internal Medicine 2002;17(3):207-210
Actinomycosis is a slowly progressive infectious disease caused by an anaerobic and microaerophilic bacteria that colonizes the face, neck, lung, pleura and the ileocecal region. There have been a few cases of this disease which have involved in the lung but one very rare case has been reported. We report a case of foreign body-induced endobronchial actinomycosis mimicking bronchogenic carcinoma in a 69-year-old man. On admission, the patient presented with weight loss, cough and hemoptysis. The fiberoptic bronchoscopy revealed a soft tissue mass, with a partial occlusion of the left upper bronchus, which resembled bronchogenic carcinoma. Contrary to the first impression, the biopsy of the bronchus revealed the mass lesion to be an actinomycotic infection involving the bronchus. After the confirmation of the lesion, treatment with penicillin was initiated. The follow-up bronchoscopy revealed an aspirated fish bone at the site of infection. The foreign body was safely removed.
Actinomycosis/*diagnosis/etiology
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Aged
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Biopsy
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Bronchi/microbiology/pathology
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Carcinoma, Bronchogenic/*diagnosis
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Case Report
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Diagnosis, Differential
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Foreign Bodies/*complications
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Human
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Lung Neoplasms/*diagnosis
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Male
10.Feasibility of galactomannan assay in bronchoalveolar lavage fluid in diagnosis of hematologic malignancy patients with invasive fungal infections.
Yun LENG ; Wen-Ming CHEN ; Jin-Wei LIU
Chinese Journal of Hematology 2011;32(8):551-552
Adolescent
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Adult
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Aged
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Bronchoalveolar Lavage Fluid
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Feasibility Studies
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Female
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Hematologic Neoplasms
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microbiology
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Humans
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Lung Diseases, Fungal
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diagnosis
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etiology
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Male
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Mannans
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analysis
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Middle Aged
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Young Adult