1.Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain.
Wan Rosmaiza Wan MUSA ; Mohamed Abdulwakil Abdulwakil ELRAIED ; Koon Seng PHANG ; Yew Gee KWAH ; Sook Pei TAN ; Roslan HARUN ; Andrea Yl BAN
Annals of the Academy of Medicine, Singapore 2010;39(8):658-659
Hemangiosarcoma
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complications
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diagnosis
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pathology
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Humans
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Lung Neoplasms
;
complications
;
diagnosis
;
pathology
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Male
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Sarcoma
;
complications
;
diagnosis
;
pathology
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Shoulder Pain
;
diagnosis
;
etiology
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Young Adult
2.A Case of Lambert-Eaton Myasthenic Syndrome Associated with Atypical Bronchopulmonary Carcinoid Tumor.
Jae Hyeok LEE ; Jin Hong SHIN ; Dae Seong KIM ; Dae Soo JUNG ; Kyu Hyun PARK ; Min Ki LEE ; Jee Yeon KIM
Journal of Korean Medical Science 2004;19(5):753-755
The Lambert-Eaton myasthenic syndrome (LEMS) is typically recognized as a paraneoplastic syndrome associated with a small cell lung carcinoma (SCLC), whereas LEMS with other neuroendocrine lung tumors, including carcinoids or large cell lung carcinoma, are highly unusual. Here, we report a rare case of LEMS with atypical bronchopulmonary carcinoid tumor: A 65-yr-old man presented with progressive leg weakness and a diagnosis of LEMS was made by serial repetitive nerve stimulation test. Chest CT revealed a lung nodule with enlargement of paratracheal lymph nodes, and surgically resected lesion showed pathological features of atypical carcinoid tumor. We concluded that LEMS could be associated with rare pulmonary neuroendocrine tumor other than SCLC, which necessitates pathologic confirmation followed by aggressive treatment for optimal management in these rare cases.
Aged
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Carcinoid Tumor/*complications/pathology/surgery
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Electromyography
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Humans
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Lambert-Eaton Myasthenic Syndrome/*complications/diagnosis
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Lung Neoplasms/*complications/pathology/surgery
;
Male
3.Application of percutaneous needle aspiration biopsy by the simulator guided to the diagnosis for pulmonary focus in coal miners' pneumoconiosis.
Si-hai LIU ; Cheng-dong QI ; Wen-shou XU ; Rui-xia ZHU ; Qin YAN ; Wen FENG ; Rong-xia SUN ; Yan-fang ZHANG ; Xiao-fu WU ; Zheng-chuan FU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(1):72-73
Aged
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Biopsy, Needle
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methods
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Coal Mining
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Humans
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Lung
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pathology
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Lung Neoplasms
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complications
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diagnosis
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Middle Aged
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Pneumoconiosis
;
complications
4.A Case of Hypertrophic Osteoarthropathy Associated with Epithelioid Hemangioendothelioma.
Jin Hyun KIM ; Eun Bong LEE ; Sunyoung KIM ; Hyoun Woo KANG ; Jung Won SUH ; Won Jae YOON ; Su Hwan KIM ; Eun Ha KANG ; Churl Hyun IM ; Yeong Wook SONG ; Hyo Suk LEE
Journal of Korean Medical Science 2004;19(3):484-486
Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome characterized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.
Adult
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Biopsy
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Blood Platelets/metabolism
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Endothelium/metabolism
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Femur/radiography
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Hemangioendothelioma, Epithelioid/*complications/*pathology
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Human
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Lung/pathology
;
Lung Neoplasms/*complications/pathology
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Male
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Osteoarthropathy, Secondary Hypertrophic/*complications/*pathology
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Vascular Endothelial Growth Factor A/metabolism
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Vascular Neoplasms/*diagnosis/pathology
5.An Unusual Radiologic Pattern of Cryptogenic Organizing Pneumonia: Diffuse Pulmonary Nodules in a Leukemia Patient.
Kai Hsiung KO ; Hsian He HSU ; Woei Yau KAO ; Ching Feng CHANG ; Ming Fang CHENG ; Guo Shu HUANG
Korean Journal of Radiology 2009;10(1):93-96
The radiological appearance of diffuse discrete pulmonary nodules associated with cryptogenic organizing pneumonia (COP) has been rarely described. We describe a case of COP in 49-year-old woman with acute myeloid leukemia who developed diffuse pulmonary nodules during the second course of induction chemotherapy. The clinical status of the patient and imaging findings suggested the presence of a pulmonary metastasis or infectious disease. A video-assisted thoracoscopic lung biopsy resulted in the unexpected diagnosis of COP as an isolated entity. Steroid therapy led to dramatic improvement of the clinical symptoms and the pulmonary lesions.
Cryptogenic Organizing Pneumonia/complications/*radiography
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Diagnosis, Differential
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Female
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Humans
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Leukemia, Myeloid, Acute/*complications/pathology
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Lung/*radiography
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Lung Neoplasms/radiography/secondary
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Middle Aged
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Multiple Pulmonary Nodules/complications/*radiography
6.Intrathoracic malignant peripheral nerve sheath tumor in von Recklinghausen's disease.
Ju Hyung PARK ; Koang Ho CHOI ; Heung Bum LEE ; Yang Keun RHEE ; Yong Chul LEE ; Myung Ja CHUNG
The Korean Journal of Internal Medicine 2001;16(3):201-204
Malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor arising from or differentiating toward the cells of the peripheral nerve sheath. MPNST accounts for about 5-10% of all soft tissue tumors and is often associated with neurofibromatosis type I (NF-1, von Recklinghausen's disease). It is one of the malignant tumors associated with von Recklinghausen's disease. Its common site is the lower and upper extremities, trunk, head and neck. But intrathoracic manifestations are very rare. We report a case of a 40 year-old man with multiple neurofibromatosis who was presented with an intrathoracic malignant peripheral nerve sheath tumor
Adult
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Case Report
;
Diaphragm/pathology
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Human
;
Lung/pathology
;
Male
;
Nerve Sheath Tumors/complications/diagnosis/*pathology
;
Neurofibromatosis 1/complications/diagnosis/*pathology
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Prognosis
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Severity of Illness Index
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Thoracic Neoplasms/complications/diagnosis/*pathology
7.Acute Upper Gastrointestinal Bleeding Due to Metastatic Lung Cancer: An Unusual Case.
Engin ALTINTAS ; Orhan SEZGIN ; Bulent UYAR ; Ayse POLAT
Yonsei Medical Journal 2006;47(2):276-277
There have been several published reports on metastatic lesions in the stomach, but the number of cases have been limited due to the low frequency of the condition. Metastatic lesions in the stomach are usually asymptomatic. A 55-year-old man with known metastatic lung adenocancer exhibited epigastric pain, hematemesis, and melena. A bleeding, ulcerated gastric metastasis was found and treated with endoscopic therapy and omeprazole.
Neoplasm Metastasis
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Middle Aged
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Male
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Lung Neoplasms/*complications/*diagnosis
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Humans
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Gastrointestinal Tract/*pathology
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Gastrointestinal Hemorrhage/diagnosis/*pathology
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Fatal Outcome
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Cell Nucleus/metabolism
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Adenocarcinoma/pathology
;
Acute Disease
8.Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients.
Xu-shi WANG ; Hai-bin SONG ; Si CHEN ; Wei ZHANG ; Jia-qi LIU ; Chao HUANG ; Hao-ran WANG ; Yuan CHEN ; Qian CHU
Journal of Huazhong University of Science and Technology (Medical Sciences) 2015;35(5):752-758
Pain perception is influenced by multiple factors. The single nucleotide polymorphisms (SNPs) of some genes were found associated with pain perception. This study aimed to examine the association of the genotypes of ABCB1 C3435T, OPRM1 A118G and COMT V108/158M (valine 108/158 methionine) with pain perception in cancer patients. We genotyped 146 cancer pain patients and 139 cancer patients without pain for ABCB1 C3435T (rs1045642), OPRM1 A118G (rs1799971) and COMT V108/158M (rs4680) by the fluorescent dye-terminator cycle sequencing method, and compared the genotype distribution between groups with different pain intensities by chi-square test and pain scores between groups with different genotypes by non-parametric test. The results showed that in these cancer patients, the frequency of variant T allele of ABCB1 C3435T was 40.5%; that of G allele of OPRM1 A118G was 38.5% and that of A allele of COMT V108/158M was 23.3%. No significant difference in the genotype distribution of ABCB1 C3435T (rs1045642) and OPRM1 A118G (rs1799971) was observed between cancer pain group and control group (P=0.364 and 0.578); however, significant difference occurred in the genotype distribution of COMT V108/158M (rs4680) between the two groups (P=0.001). And the difference could not be explained by any other confounding factors. Moreover, we found that the genotypes of COMT V108/158M and ABCB1 C3435T were associated with the intensities of pain in cancer patients. In conclusion, our results indicate that the SNPs of COMT V108/158M and ABCB1 C3435T significantly influence the pain perception in Chinese cancer patients.
ATP Binding Cassette Transporter, Sub-Family B
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genetics
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Adult
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Aged
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Aged, 80 and over
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Alleles
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Breast Neoplasms
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complications
;
diagnosis
;
genetics
;
pathology
;
Catechol O-Methyltransferase
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genetics
;
Female
;
Gastrointestinal Neoplasms
;
complications
;
diagnosis
;
genetics
;
pathology
;
Gene Expression
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Gene Frequency
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Genital Neoplasms, Female
;
complications
;
diagnosis
;
genetics
;
pathology
;
Genital Neoplasms, Male
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complications
;
diagnosis
;
genetics
;
pathology
;
Genotype
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Humans
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Lung Neoplasms
;
complications
;
diagnosis
;
genetics
;
pathology
;
Male
;
Middle Aged
;
Pain
;
complications
;
diagnosis
;
genetics
;
pathology
;
Pain Measurement
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Pain Perception
;
Polymorphism, Single Nucleotide
;
Receptors, Opioid, mu
;
genetics
9.Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia.
Kerem OKUTUR ; Baris HASBAL ; Kubra AYDIN ; Mustafa BOZKURT ; Esat NAMAL ; Buge OZ ; Kamil KAYNAK ; Gokhan DEMIR
Journal of Korean Medical Science 2010;25(12):1805-1808
Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (beta hCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. beta hCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for beta hCG. Serum beta hCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, beta hCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. beta hCG expression may be associated with aggressive clinical course and increased risk of recurrence, also beta hCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
Brain Neoplasms/radiotherapy/secondary
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Carcinoma, Non-Small-Cell Lung/complications/*diagnosis/pathology
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Chorionic Gonadotropin, beta Subunit, Human/*blood
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Gynecomastia/*etiology
;
Humans
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Lung Neoplasms/complications/*diagnosis/pathology
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Lymph Nodes/surgery
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Male
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Middle Aged
;
Recurrence
;
Risk Factors
;
Tomography, X-Ray Computed
10.Foreign body-induced Actinomycosis Mimicking Bronchogenic Carcinoma.
Young Shin KIM ; Ju Hyun SUH ; Seung Min KWAK ; Jeong Seon RYU ; Chul Ho CHO ; Chan Sup PARK ; Soo Kee MIN
The Korean Journal of Internal Medicine 2002;17(3):207-210
Actinomycosis is a slowly progressive infectious disease caused by an anaerobic and microaerophilic bacteria that colonizes the face, neck, lung, pleura and the ileocecal region. There have been a few cases of this disease which have involved in the lung but one very rare case has been reported. We report a case of foreign body-induced endobronchial actinomycosis mimicking bronchogenic carcinoma in a 69-year-old man. On admission, the patient presented with weight loss, cough and hemoptysis. The fiberoptic bronchoscopy revealed a soft tissue mass, with a partial occlusion of the left upper bronchus, which resembled bronchogenic carcinoma. Contrary to the first impression, the biopsy of the bronchus revealed the mass lesion to be an actinomycotic infection involving the bronchus. After the confirmation of the lesion, treatment with penicillin was initiated. The follow-up bronchoscopy revealed an aspirated fish bone at the site of infection. The foreign body was safely removed.
Actinomycosis/*diagnosis/etiology
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Aged
;
Biopsy
;
Bronchi/microbiology/pathology
;
Carcinoma, Bronchogenic/*diagnosis
;
Case Report
;
Diagnosis, Differential
;
Foreign Bodies/*complications
;
Human
;
Lung Neoplasms/*diagnosis
;
Male