4.Research Advances of Pan-negative Type of Non-small Cell Lung Cancer.
Li SUN ; Zhicheng XIONG ; Chengbo HAN
Chinese Journal of Lung Cancer 2018;21(2):129-138
In recent years, series of driver genes, such as EGFR, KRAS/NRAS, BRAF, PIK3CA, ALK and ROS1 and so on, have been found in non-small cell lung cancer (NSCLC) one after another with the development of molecular detecting technology. Targeted drugs bring benefits for these NSCLC patients with driver gene variations. However, some NSCLC did not have any known driver gene variations; we called it pan-negative lung cancer. In this paper, we summarize the concept, clinical pathological characteristics, the epidemiological characteristics, treatment and prognosis of pan-negative NSCLC.
Carcinoma, Non-Small-Cell Lung
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diagnosis
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drug therapy
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genetics
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pathology
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Humans
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Lung Neoplasms
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diagnosis
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drug therapy
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genetics
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pathology
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Mutation
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Prognosis
5.Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension.
Hayyam KIRATLI ; Bercin TARLAN ; Figen SOYLEMEZOGLU
Korean Journal of Ophthalmology 2013;27(3):215-218
Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient.
Carcinoma/*pathology/therapy
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Choroid/*pathology
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Choroid Neoplasms/*secondary/therapy
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Humans
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Hyperthermia, Induced
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Lung Neoplasms/secondary
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Male
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Middle Aged
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Sclera/*pathology
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Thyroid Neoplasms/*pathology/therapy
6.Skip metastasis of prostate cancer: diagnosis and treatment.
Jun-Qi WANG ; Wang LI ; Qiang WANG ; Kun LIU ; Li-Jun MAO ; Jia-Cun CHEN ; Jun-Nian ZHENG ; Xiao-Qing SUN
National Journal of Andrology 2009;15(12):1120-1123
OBJECTIVETo improve the diagnosis and treatment of far advanced prostate cancer without clinically detectable bone metastasis.
METHODSCancer metastatic lesions were found in the liver and lungs respectively of two patients on routine medical examination, and only an abnormally elevated level of the serum prostate specific antigen (PSA) was observed in the following system examinations. The patients were diagnosed as having prostate cancer by prostate biopsy. MRI showed a discontinued prostate capsule, and ECT revealed no bone metastasis. Diagnostic treatment was conducted by giving LHRHa combined with antiandrogens. One of the patients underwent surgical castration at 12 months, and both received intensity modulated radiation therapy (80 Gy) at 15 and 18 months, respectively.
RESULTSThe metastatic lesions in the liver and lungs of the patients were either absent or significantly reduced after treated by maximal androgen blockade for 3 months, and all disappeared after 6 months'treatment, with the PSA level stabilized at less than 0.02 microg/L in one patient, and around 0.5 microg/L in the other. Antiandrogen treatment was suspended after radiotherapy. The results of liver, lung and bone scanning were normal during the 12-month follow-up, and the PSA level was below 1.0 microg/L.
CONCLUSIONRemote metastasis of prostate cancer may occur in ectosteal organs first, which deserves special attention. A combination of different treatment methods promises satisfactory results.
Aged ; Humans ; Liver Neoplasms ; secondary ; Lung Neoplasms ; secondary ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms ; diagnosis ; pathology ; therapy
7.Result of Surgical Treatment of Stage IIIB Lung Cancer.
Gi Pyo HONG ; Kil Dong KIM ; Hyun Sung LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 2000;33(2):173-178
BACKGROUND: Though the surgical treatment of stage IIIB lung cancer is not generalized due to low complete remission rate high morbidity and mortality there are several reports on the improvement of long term survival after preoperative and postoperative adjuvant therapy. In this study we analyzed the prognostic factors affecting long term survival after surgical treatment of stage IIIB lung cancer MATERIAL AND METHOD: We analyzed the long term survival for age pathology invaded mediastinal organ n stage type of operation complete or incomplete resection and adjuvant therapy through a retrospective review of patients underwent surgical treatment. RESULT: From 1990 to 1998 56 patients(51/male 5/female0 with stage IIIB lung cancer were trated surgically. Forty two patients underwent radical resection and morbidity and mortality were 17% 12% respectively. The survival rate for overall patients and the radical resection group were 9% 12% respectively. In the radical resection group excluding explothoracotomy only(n=14) and the surgical mortality patients(n=5) the age the type of operation celly type resectability and N stage had no influence on the long term survival. The survival rate of radical resection group was significantly better than that of the explothoracotomy only group(p=0.04) The long term survival rate of postoperative combination therapy group was significantly better than chemotherapy or radiotherapy alone(p=0.04) CONCLUSION: Age type after surgical treatment of stage IIIB lung cancer. We conclude that combined modality of adjuvant treatment after radical resection of stage IIIB lung cancer seems to offer better long term survival in selective patients. The numbers of patients involved was small. Nevertheless these preliminary findings indicate questions that will need to be experienced further in larger studies.
Drug Therapy
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Humans
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Lung Neoplasms*
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Lung*
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Mortality
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Neoplasm Staging
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Pathology
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Radiotherapy
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Retrospective Studies
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Survival Rate
8.Paradoxical effects of arsenic in the lungs.
Caixia REN ; Yang ZHOU ; Wenwen LIU ; Qi WANG
Environmental Health and Preventive Medicine 2021;26(1):80-80
High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of previous studies, we infer that low- and medium-concentration arsenic cause lung diseases in a dose-dependent manner. Arsenic trioxide (ATO) is recognized as a chemotherapeutic drug for acute promyelocytic leukemia (APL), also having a significant effect on lung cancer. The anti-lung cancer mechanisms of ATO include inhibition of proliferation, promotion of apoptosis, anti-angiogenesis, and inhibition of tumor metastasis. In this review, we summarized the role of arsenic in lung disease from both pathogenic and therapeutic perspectives. Understanding the paradoxical effects of arsenic in the lungs may provide some ideas for further research on the occurrence and treatment of lung diseases.
Animals
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Arsenic/toxicity*
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Dose-Response Relationship, Drug
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Humans
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Lung/pathology*
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Lung Neoplasms/drug therapy*
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Mice
9.Coexisting metastatic choriocarcinoma and bladder adenocarcinoma of common germ cell origin.
Amit JAIN ; Norene LIEW ; Whay Kuang CHIA ; Sung Hock CHEW ; Yin Nin CHIA ; Tse Hui LIM ; Alvin LIM ; Sheow Lei LIM ; Chin Fong WONG ; Khai Lee TOH ; Min Han TAN
Annals of the Academy of Medicine, Singapore 2011;40(12):548-549
Adenocarcinoma
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pathology
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therapy
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Choriocarcinoma, Non-gestational
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pathology
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therapy
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Combined Modality Therapy
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Female
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Humans
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Lung Neoplasms
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secondary
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Middle Aged
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Neoplasms, Germ Cell and Embryonal
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pathology
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therapy
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Urinary Bladder Neoplasms
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pathology
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therapy
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Uterine Neoplasms
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pathology
;
therapy
10.The role of TBNA in diagnosis and treatment of lung diseases.
Chinese Journal of Lung Cancer 2010;13(5):396-400
In the last 30 years, clinical application oftransbronchial needle aspiration (TBNA) has proved its efficiency, accuracy, safety and cost-effectiveness, particularly in diagnosing and staging lung cancer as well as in diagnosing benign diseases. The application of endobronchial ultrasound (EBUS) increased the accuracy of TBNA. Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has superior performance and allowing real-time sampling under direct vision. Combination of EUBS-TBNA and traditional methods (CT, PET, mediastinoscopy, et al) can improve the diagnostic rate and negative predictive value. In the future, EUBS-TBNA may have applications in both benign and malignant lung diseases as a routine examination.
Biopsy, Fine-Needle
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methods
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Bronchi
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pathology
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Humans
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Lung Neoplasms
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diagnosis
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pathology
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therapy
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Neoplasm Staging