1.Marked Recovery From Paraquat-Induced Lung Injury During Long-Term Follow-up.
Kwon Hyun LEE ; Hyo Wook GIL ; Young Tong KIM ; Jong Oh YANG ; Eun Young LEE ; Sae Yong HONG
The Korean Journal of Internal Medicine 2009;24(2):95-100
BACKGROUND/AIMS: Paraquat-induced lung injury has been considered a progressive and irreversible disease. The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up for longer than 6 months. METHODS: We retrospectively examined high-resolution computed tomography and pulmonary function test of eight survivors with significant paraquat-induced lung injurys. RESULTS: High-resolution computed tomography revealed a predominant pattern of irregularly shaped consolidation with traction bronchiectasis at 1-2 months after paraquat poisoning, a mixed pattern of irregularly shaped consolidation and ground-glass opacity at 3-12 months, and a mixed pattern of consolidation, groundglass opacity, and honeycombing at 1-2 years. At 3-12 months after paraquat ingestion, the areas of consolidation had markedly decreased and the decreased lung volume had returned to normal. At 1-2 years after paraquat poisoning, the cystic changes had disappeared. At 2-3 years after paraquat poisoning, the decrease in forced vital capacity had greatly improved to the normal range. CONCLUSIONS: Recovery of nearly normal pulmonary structure and function may occur over several years following paraquat poisoning. Pulmonary function (both forced vital capacity and forced expiratory volume in 1 sec) evolved toward normal in the long-term survivors of paraquat poisoning with initial prominent lung injuries.
Adolescent
;
Adult
;
Aged
;
Bronchiectasis/chemically induced
;
Female
;
Follow-Up Studies
;
Forced Expiratory Volume
;
Herbicides/*toxicity
;
Humans
;
Lung/*drug effects/physiopathology/radiography
;
Lung Injury/*chemically induced/physiopathology/radiography/therapy
;
Lung Volume Measurements
;
Male
;
Middle Aged
;
Paraquat/*toxicity
;
Pulmonary Fibrosis/chemically induced
;
Recovery of Function
;
Retrospective Studies
;
*Survivors
;
Time Factors
;
Tomography, X-Ray Computed
;
Vital Capacity
;
Young Adult
2.Clinical Outcome of Paraquat Poisoning.
The Korean Journal of Internal Medicine 2009;24(2):93-94
No abstract available.
Bronchiectasis/chemically induced
;
Forced Expiratory Volume
;
Herbicides/*toxicity
;
Humans
;
Lung/*drug effects/physiopathology/radiography
;
Lung Injury/*chemically induced/physiopathology/radiography/therapy
;
Lung Volume Measurements
;
Paraquat/*toxicity
;
Pulmonary Fibrosis/chemically induced
;
Recovery of Function
;
*Survivors
;
Time Factors
;
Tomography, X-Ray Computed
;
Vital Capacity