1.A case of parenchymal pulmonary endometriosis.
Yoon Joo HONG ; Hyo Chae PAIK ; Hyung Joong KIM ; Doo Yun LEE ; Sang Jin KIM ; Sang Ho CHO ; Yoon Mi OH
Yonsei Medical Journal 1999;40(5):514-517
Pulmonary Endometriosis is a rare disease entity and we report a 23-year-old single woman with a history of hemoptysis in association with menstruation. She was previously treated effectively with hormone therapy for 3 months, but decided to undergo surgical resection because of the high cost of hormone therapy. Radiographic finding of the chest showed haziness in the right lower lung field, and chest CT showed a ground-glass appearance in the posterobasal and laterobasal segment. The patient underwent basal segmentectomy of the right lower lobe. There was no incidence of hemoptysis during her menstruation following the operation.
Adult
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Case Report
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Endometriosis/therapy*
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Endometriosis/etiology
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Endometriosis/diagnosis
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Female
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Human
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Lung Diseases/therapy*
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Lung Diseases/etiology
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Lung Diseases/diagnosis
3.Pleural Aspergillosis.
Hyun Cheol CHUNG ; Joon CHANG ; Chul Min AHN ; Sung Kyu KIM ; Won Young LEE ; Doo Yon LEE
Yonsei Medical Journal 1988;29(1):84-88
Pleural aspergillosis is an uncommon disease; only 29 cases have reported in the literature since 1958. We reported a patient with a pleural aspergillosis complicated a preexisting chronic empyema. Treatment consisted of pleuropneumonectomy, creation of an pleurocutaneous window followed by an intrapleural instillation of nystatin.
Aged
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Aspergillosis/diagnosis/*etiology/therapy
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Case Report
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Empyema/complications
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Human
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Lung Diseases, Fungal/diagnosis/*etiology/therapy
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Male
4.A case with systemic disseminated fungal disease and reactive histiocytosis.
Chinese Journal of Pediatrics 2004;42(5):397-397
Antifungal Agents
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therapeutic use
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Fever
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Histiocytosis
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drug therapy
;
etiology
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Humans
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Infant
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Lung Diseases, Fungal
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complications
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diagnosis
;
drug therapy
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Male
5.Diagnosis and treatment of lung aspergillosis after liver transplantation.
Qi-yuan LIN ; Yong-heng ZHAO ; Lü-nan YAN ; An-hua HUANG ; Bo LI ; Shi-chun LU ; Yong ZENG ; Tian-fu WEN ; Ji-chun ZHAO ; Nan-sheng CHENG
Chinese Journal of Surgery 2003;41(1):17-18
OBJECTIVETo assess the diagnosis and treatment of invasive lung aspergillosis after liver transplantation.
METHODSRoutine sputum culture was performed. Itraconazole and fluconazole were used to prevent fungal infection prophylactically. Amphyotericin B was only used on aspergillosis. In 54 patients receiving, liver transplantation, 3 patients with lung aspergillosis were reviewed.
RESULTSOf the 3 patients 2 died and 1 recovered.
CONCLUSIONSOver-immunosuppression is a main risk factor for aspergillosis. Amphotericin B is still the best choice for the treatment of aspergillosis and its gradual, interrupted, low concentration administration, cooperated with itraconazole can ease the side effects.
Adult ; Aspergillosis ; diagnosis ; drug therapy ; etiology ; Female ; Humans ; Liver Transplantation ; adverse effects ; Lung Diseases, Fungal ; diagnosis ; drug therapy ; etiology ; Male ; Middle Aged
6.Aspergillus pneumonia in renal transplant recipients.
Xiao-dong ZHANG ; Xiao-peng HU ; Hang YIN ; Wei WANG ; Xin ZHANG ; Lin-Lin MA ; Yong WANG
Chinese Medical Journal 2008;121(9):791-794
BACKGROUNDFilamentous fungal infections are associated with a high morbidity and mortality in solid organ transplants. The present study aimed to investigate the aspergillus pneumonia in renal transplant recipients, and its diagnosis as well as treatment.
METHODSApproximately 2000 cases of renal transplants were retrospectively studied and we focused on cases hospitalized during August 1, 2005 and February 1, 2007, as the study period. The clinical database and electronic records were analyzed. Recently published literature was reviewed.
RESULTSThere was more diabetes and hypertension in the infected group than in the non-infected group (86% vs 62% and 57% vs 39%, respectively). Eighty-six percent of recipients from the infected group had delayed graft function. Seven cases with aspergillus pneumonia were identified based on either fungal culture or radiology. Of the 7 cases, 4 died in a few days after diagnosis. Liposomal amphotericin B was used as a first-line therapy.
CONCLUSIONSIncidences of fungal infection are increasing among renal transplant recipients. Early diagnosis and treatment are critical steps in curing aspergillosis.
Adult ; Aspergillosis ; diagnosis ; drug therapy ; etiology ; Cohort Studies ; Female ; Humans ; Kidney Transplantation ; adverse effects ; Lung Diseases, Fungal ; diagnosis ; drug therapy ; etiology ; Male ; Middle Aged ; Pneumonia ; diagnosis ; drug therapy ; etiology ; Retrospective Studies ; Tomography, X-Ray Computed
7.Diagnosis and treatment of invasive aspergillosis infection following orthotopic liver transplantation.
Shu-hong YI ; Gui-hua CHEN ; Min-qiang LU ; Yang YANG ; Chang-jie CAI ; Chi XU ; Hua LI ; Gen-shu WANG ; Hui-min YI
Chinese Journal of Surgery 2006;44(13):885-888
OBJECTIVETo explore the treatment and appropriate management of invasive aspergillosis infection following orthotopic liver transplantation.
METHODSThe clinical data of 576 cases who underwent orthotopic liver transplantation consecutively between January 2000 and January 2005 were analyzed retrospectively.
RESULTSThe prevalence of invasive aspergillosis infection was 1.74 (9/576), included 8 cases with pulmonary aspergillosis and 1 case with cerebral aspergillosis. The interval between transplantation and diagnosis were from 10 days to 2 months. Persistent or discontinuous low fever maybe the main clinical presentation after operation. Liposomal amphotericin B (AmBisome) is the mainly treatment for invasive aspergillosis infections, 5 patients were cured and 2 patients developed multi-organ aspergillosis infection died.
CONCLUSIONSThe clinical features of invasive aspergillosis infection following orthotopic liver transplantation were un-typical presentations in the early stage and easy to disseminate. Appropriate modification of immunosuppression therapy and early, high dose and long-term application of antifungal treatment is effective and safe to cure the disease.
Adult ; Aged ; Amphotericin B ; therapeutic use ; Antifungal Agents ; therapeutic use ; Aspergillosis ; diagnosis ; drug therapy ; etiology ; Female ; Humans ; Liver Transplantation ; adverse effects ; Lung Diseases, Fungal ; diagnosis ; drug therapy ; etiology ; Male ; Middle Aged ; Neuroaspergillosis ; diagnosis ; drug therapy ; etiology ; Postoperative Complications ; Retrospective Studies
8.Pulmonary fungal infection in malignant hematological diseases: an analysis of 14 cases.
Qi SHEN ; Xian-Min SONG ; Xiao-Ping XU ; Jian-Min WANG
Journal of Experimental Hematology 2005;13(6):1125-1127
The objective of this study was to evaluate the etiological factors, diagnosis and therapy of pulmonary fungal infection in hematological malignancies, 14 cases of malignant hematological disease with pulmonary fungal infection were collected and analyzed. The results showed that 11 out of 14 cases had the respiratory manifestations, sputum was sticky and difficult to be expectorated in 7 cases, X rays in chests showed shadows with features of stigma and sheet in 11 cases, Candida albicans and aspergillus infection were observed in 10 and 2 cases respectively, the numbers of neutrophil were below 0.5 x 10(9)/L in 8 cases and below 1.0 x 10(9)/L in 3 cases respectively, fluconazole was used for 12 cases and clinical symptoms of 11 cases were improved within two weeks. In conclusion, the occurrence of pulmonary fungal infection in malignant hematological diseases is associated with intensive chemotherapy, decrease of neutrophil counts and using of broad-spectrum antibiotics, the diagnosis at early stage is difficult and clinicians should pay more attention to its clinical and laboratory examinations, and give them therapy in time.
Adolescent
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Adult
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Aged
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Antifungal Agents
;
therapeutic use
;
Aspergillosis
;
complications
;
diagnosis
;
drug therapy
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Candidiasis
;
complications
;
diagnosis
;
drug therapy
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Female
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Fluconazole
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therapeutic use
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Hematologic Neoplasms
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drug therapy
;
etiology
;
pathology
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Humans
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Lung Diseases, Fungal
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complications
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diagnosis
;
drug therapy
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Male
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Middle Aged
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Treatment Outcome
9.A case of granulomatous lung disease in a patient with Good's syndrome.
Seung Heon LEE ; Sang Min LEE ; Seok Chul YANG ; Chul Gyu YOO ; Young Whan KIM ; Young Soo SHIM ; Sung Koo HAN
The Korean Journal of Internal Medicine 2008;23(4):219-222
Good's syndrome is extremely rare. This adult-onset condition is characterized by a thymoma with immunodeficiency, low B- and T-cell counts, and hypo-gammaglobulinemia. The initial clinical presentation is either a mass-lesion thymoma or a recurrent infection. Patients with Good's syndrome are very susceptible to infections; common respiratory and opportunistic infections can be life-threatening. There are no reports of granulomatous lung disease in patients with Good's syndrome, although it has been observed in patients with common variable immunodeficiency, of which Good's syndrome is a subset. We describe a 53-year-old male thymoma patient who presented with respiratory symptoms caused by granulomatous lung disease and an opportunistic infection. He died of uncontrolled fungal infection despite repeated intravenous immunoglobulin and supportive care. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with severe recurrent infections, especially opportunistic infections.
Fatal Outcome
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Granuloma, Respiratory Tract/diagnosis/*etiology/therapy
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Humans
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Immunologic Deficiency Syndromes/*complications/immunology/pathology
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Lung Diseases/diagnosis/*etiology/therapy
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Male
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Middle Aged
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Thymoma/*complications/immunology/pathology
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Thymus Neoplasms/*complications/immunology/pathology
10.Clinical features of invasive pulmonary fungal infection secondary to malignant blood diseases.
Xue-Feng SUN ; Bing HAN ; Jun FENG ; Dao-Bin ZHOU ; Shu-Jie WANG ; Ying XU ; Jia-Lin CHEN ; Li JIAO ; Wei ZHANG ; Jian LI ; Ming-Hui DUAN ; Tie-Nan ZHU ; Nong ZOU ; Bao-Lai HUA ; Hua-Cong CAI ; Yong-Qiang ZHAO
Acta Academiae Medicinae Sinicae 2009;31(5):575-579
OBJECTIVETo summarize the clinical features of invasive pulmonary fungal infection (IPFI) secondary to malignant blood diseases (MBD).
METHODSWe retrospectively analyzed the clinical data of 52 patients with IPFI secondary to MBD admitted to Peking Union Medical College Hospital from January 1995 to December 2008.
RESULTSThe incidences of IPFI secondary to acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), non-Hodgkin's lymphoma (NHL), and aplastic anemia (AA) were 4.6%, 3.2%, 2.8%, and 2.5%, respectively. In patients with IPFI secondary to AML, 88.5% (23/26) of the patients suffered from the infections during the non-remission (NR) period (including relapse), and 11.5% (3/26) in the complete-remission (CR) period. In all the patients with IPFI secondary to malignant blood diseases, 86.5% (45/52) of MBD were neutropenic or agranulocytic, and 67.3% (35/52) had been treated with broad-spectrum antibiotics for more than 96 hours before anti-fungal therapy. The total mortality after anti-fungal therapy was 13.7% (7/51). More than half of patients with fluconazole or itraconazole as the first-line therapy had to switch to other medicines because of poor infection control.
CONCLUSIONSIPFI secondary to MBD is most common in AML patients. Patients with NR of AML, neutropenia or agranulocytosis, and long-term broad-spectrum antibiotics usage are susceptible to IPFI. Fluconazole and itraconazole have low efficacy, and other more potent anti-fungal medicines should be considered.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Hematologic Neoplasms ; complications ; Humans ; Lung Diseases, Fungal ; diagnosis ; drug therapy ; etiology ; Male ; Middle Aged ; Retrospective Studies ; Young Adult