1.Pharmacotherapy of Chronic Obstructive Pulmonary Diseases.
Journal of the Korean Medical Association 1998;41(4):442-450
No abstract available.
Drug Therapy*
;
Lung Diseases, Obstructive*
2.Childhood pulmonary aspergillosis: report of three cases.
Li-Jie WANG ; Chun-Feng LIU ; Li-Xia ZHOU
Chinese Journal of Contemporary Pediatrics 2010;12(5):401-403
Aspergillosis
;
diagnosis
;
drug therapy
;
Child, Preschool
;
Female
;
Humans
;
Infant
;
Lung Diseases, Fungal
;
diagnosis
;
drug therapy
;
Male
3.Consideration on the Research and Development of New Drugs for Rare Tumors.
Ling TANG ; Yuanyuan SONG ; Zhimin YANG
Chinese Journal of Lung Cancer 2022;25(7):443-447
In recent years, China's anti-tumor drugs has shown a continuous growth trend, and the activity of anti-tumor research and development in China accounts for a higher proportion in the world. However, further analysis of research and development hotspots show that the research and development of anti-tumor drugs is uneven among different tumor types. Due to the small number of the patients, it is difficult to conduct clinical trials, resulting in less drug development in the field of rare tumors. However, patients' treatment needs will also bring potential opportunities for pharmaceutical companies. The development of basic research and the discovery of new molecular tumor typing make "rare tumors" a dynamic concept. The scope of "rare tumors" may gradually expand with the precise development of treatment; or as the knowledge of tumors gradually develops from histocytology to the molecular level, It is possible that certain tumors with specific mutations can be combined into a group of non-rare "pan-tumors". Rare tumors are characterized by both rare diseases and tumors. Its drug research and development should not only meet the requirements of tumor drug research and development, but also adapt to the characteristics of rare diseases. Therefore, in the drug research and development, we can refer to the research and development principle of rare disease drugs, combine with the characteristics of tumor diseases, make full use of non-rare tumor clinical trials, make full use of scientific tools and exquisite trial design, and realize the promotion of the research and development of rare tumor drugs. This paper will summarize the thoughts in the review of new drugs in the field of rare tumors, in order to provide guidance for the industry.
.
Antineoplastic Agents/therapeutic use*
;
China
;
Humans
;
Lung Neoplasms/drug therapy*
;
Rare Diseases/drug therapy*
;
Research
4.Research progress in pharmacological effectsand mechanism of Fel Ursi against cardiovascular and cerebrovascular diseases.
Li-Dan ZHU ; Jie LIAO ; Xiao-Yan LU ; Xiao-Hui FAN
China Journal of Chinese Materia Medica 2023;48(23):6307-6314
Fel Ursi is a dried product obtained from the gallbladder of Ursidae animals, such as Selenarctos thibetanus or Ursus arctos, through gallbladder surgery for bile drainage. It is one of the rare animal medicinal materials in China and is known for its therapeutic effects, including clearing heat, removing toxins, extinguishing wind, relieving spasms, clearing the liver, and improving vision. Research has also found that Fel Ursi has pharmacological effects against cardiovascular and cerebrovascular diseases, such as anti-inflammatory, anti-apoptotic, and antioxidant stress properties. Recently, numerous studies have confirmed the close relationship between cardiovascular and cerebrovascular diseases and the gut microbiota as well as gut metabolites. Fel Ursi contains bile acid components that may have bidirectional regulatory effects on the gut microbiota and gut metabolites. This aspect could represent a potential therapeutic pathway for Fel Ursi in the treatment of cardiovascular and cerebrovascular diseases. This article comprehensively summarized relevant literature in China and abroad, reviewed the research progress on the pharmacological effects of Fel Ursi against cardiovascular and cerebrovascular diseases, and explored the impact of Fel Ursi on gut microbiota and gut metabolites, thereby aiming to provide references for further in-depth research and clinical application of Fel Ursi.
Animals
;
Cerebrovascular Disorders/drug therapy*
;
Bile Acids and Salts
;
Lung
;
Liver
;
Ursidae
;
Cardiovascular Diseases/drug therapy*
5.A Phase II Study of Paclitaxel and Cisplatin Combination Chemotherapy in Advanced Non-small-cell Lung Cancer.
Jung Ae LEE ; Keun Seok LEE ; Jin Seok AHN ; Jae Ho BYUN ; Hun Ho SONG ; Dae Young ZANG ; Young Iee PARK ; Young Suk PARK ; Eun Kyung MO ; Dong Kyu KIM ; Myung Goo LEE ; In Gyu HYUN ; Ki Suck JUNG ; Soo Mee BANG ; Gye Young PARK ; Jeong Woong PARK ; Eun Kyung CHO ; Seong Hwan JEONG ; Dong Bok SHIN ; Jae Hoon LEE
Cancer Research and Treatment 2003;35(3):239-244
PURPOSE: Paclitaxel and cisplatin, active drugs in the treatment of non-small-cell lung cancer (NSCLC), have been found to be synergistic and less myelotoxic in combination when the paclitaxel is given 24 hr prior to the cisplatin. Their antitumor activity and toxicity in patients with advanced NSCLC has been evaluated herein. MATERIALS AND METHODS: Seventy-four chemonaive patients, with advanced NSCLC, were enrolled. Paclitaxel, 175 mg/m2, was administered on day 1, followed 24 hr later by cisplatin, 75 mg/m2, on day 2. RESULTS: The overall response rate, median time to progression and median survival time were 51%, 7.1 months (95% confidence interval (CI), 5.5~8.7 months) and 13.7 months (95% CI, 11.3~16.1 months), respectively. There were significant differences in the overall survival rates in relation to stage and the ECOG performance status(PS). The toxicity was mainly nonhematological. Grade > or =3 neuropathy occurred in 2 (3%) patients, myalgia in 3 (4%), and bone pain in 3 (4%). The hematological toxicity was mild, and no grade 3 or 4 neutropenia was observed. CONCLUSION: The combination of paclitaxel and cisplatin is an effective and tolerable treatment regimen for advanced NSCLC during first line chemotherapy. The main toxicity was nonhematological, such as peripheral neuropathy, myalgia and bone pain, whereas the hematological toxicity itself was mild.
Cisplatin*
;
Drug Therapy
;
Drug Therapy, Combination*
;
Humans
;
Lung Neoplasms*
;
Lung*
;
Myalgia
;
Neutropenia
;
Paclitaxel*
;
Peripheral Nervous System Diseases
;
Survival Rate
6.Epiphora following chemotherapy with pemetrexed in patients with advanced non-small cell lung cancer.
Yun Duk JUNG ; Sang Bin LEE ; Yun Wha JUNG ; Jung Sub SONG ; In Sook WOO
The Korean Journal of Internal Medicine 2017;32(5):923-925
No abstract available.
Carcinoma, Non-Small-Cell Lung*
;
Drug Therapy*
;
Humans
;
Lacrimal Apparatus Diseases*
;
Lung Neoplasms
;
Pemetrexed*
7.Idiopathic airway-centered interstitial fibrosis: report of two cases.
Xiang-hua YI ; Hai-qing CHU ; Xiao-ming CHENG ; Ben-fang LUO ; Hui-ping LI
Chinese Medical Journal 2007;120(9):847-850
Adult
;
Diagnosis, Differential
;
Humans
;
Lung
;
pathology
;
Lung Diseases, Interstitial
;
diagnosis
;
drug therapy
;
pathology
;
Male
;
Middle Aged
8.Photodynamic therapy for malignant and non-malignant diseases: clinical investigation and application.
Yong-gang QIANG ; Xiu-ping ZHANG ; Jian LI ; Zheng HUANG
Chinese Medical Journal 2006;119(10):845-857
Brain Neoplasms
;
drug therapy
;
Cardiovascular Diseases
;
drug therapy
;
Eye Diseases
;
drug therapy
;
Gastrointestinal Neoplasms
;
drug therapy
;
Head and Neck Neoplasms
;
drug therapy
;
Humans
;
Lung Neoplasms
;
drug therapy
;
Neoplasms
;
drug therapy
;
Photochemotherapy
;
Precancerous Conditions
;
drug therapy
;
Skin Diseases
;
drug therapy
;
Skin Neoplasms
;
drug therapy
;
Tooth Diseases
;
drug therapy
;
Urologic Neoplasms
;
drug therapy
9.The Studies on the Development of Radiation Pneumonitis and Its Related Factors.
Journal of the Korean Society for Therapeutic Radiology 1987;5(2):119-130
With the introduction of X-rays of higher energy that have higher penetrability, it has become possible to treat the deep-seated tumor with increased local control rate. But at the same time it has incrased the damage to the deep seated organs, especially to the lung which is known to be the less radiotolerable tissue in the body. This study analyses the 66 patients who were exposed to the irradiation of the lung, and examines the development of radiation pneumonitis and its related factors. The results of the study are summarized as folows : 1. The 66 patients were consisted of 40 cases of lung cancer, 15 cases of breast cancer and 11 cases of mediastinal tumors. There were 37 males and 29 females with the male to female ratio 1.3 : 1. A male to female ratio in the lung cancer was 3 : 1. 2. Among 66 patients, 26 patients (39%) developed the radiographical changes of acute radiation pneumonitis and 13 out of 26 patients (50%) showed the clinical features of acute radiation pneumonitis. 3. The onest of acute radiation pneumonitis ranged from 10 days to 6 months after the completion of radiotherapy. 4. There was a statistically significant close relationship between the development of radiation pneumonitis and the radiation dose. 5. As the irradiated lung volume increased, the development of radiation pneumonitis increased. But the statistical significance was not strong. 6. The increased incidence of radiation pneumonitis was observed when the chemotherapy was given before or concomittantly with radiotherapy. 7. There was no significant correlation between the development of radiation pneumonitis and the age, smoking and the presence of underlying lung disease.
Breast Neoplasms
;
Drug Therapy
;
Female
;
Humans
;
Incidence
;
Lung
;
Lung Diseases
;
Lung Neoplasms
;
Male
;
Radiation Pneumonitis*
;
Radiotherapy
;
Smoke
;
Smoking
10.A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia.
Chang Hoon HAHN ; Jin Wook MOON ; Jae Hyun CHANG ; Byoung Wook CHOI ; Dong Whan SHIN ; Se Kyu KIM ; Joon CHANG ; Sung Kyu KIM ; Young Sam KIM
Tuberculosis and Respiratory Diseases 2003;55(3):311-316
A 34-year-old man was admitted to our hospital due to fever and cough. He received the combination anti-cancer chemotherapy for testicular tumor, including bleomycin. The chest X-ray showed consolidation and ground glass opacity on the right upper lobe and subpleural areas of other lobes. This condition was initially misdiagnosed as a pneumonia, but consolidation did not disappear after antibiotics treatment. We performed transbronchial lung biopsy and bleomycin induced pulmonary toxicity was confirmed. The bleomycin induced lung injury is the most common chemotherapeutically induced pulmonary disease. Bleomycin induced Bronchiolitis Obliterans Organizing Pneumonia(BOOP) is less common than interstitial pneumonitis and respond well to corticosteroid treatment.
Adult
;
Anti-Bacterial Agents
;
Biopsy
;
Bleomycin
;
Bronchiolitis Obliterans*
;
Bronchiolitis*
;
Cough
;
Cryptogenic Organizing Pneumonia*
;
Drug Therapy
;
Fever
;
Glass
;
Humans
;
Lung
;
Lung Diseases
;
Lung Diseases, Interstitial
;
Lung Injury
;
Pneumonia
;
Thorax