1.A Case of Venlafaxine-Induced Interstitial Lung Disease.
Serim OH ; Seung Ick CHA ; Hyera KIM ; Minjung KIM ; Sun Ha CHOI ; Hyewon SEO ; Tae In PARK
Tuberculosis and Respiratory Diseases 2014;77(2):81-84
A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD.
Alveolitis, Extrinsic Allergic
;
Bronchiectasis
;
Depression
;
Glass
;
Humans
;
Hypersensitivity
;
Lung
;
Lung Diseases, Interstitial*
;
Perfusion
;
Pneumonia
;
Traction
;
Venlafaxine Hydrochloride
2.Research progress of thyroid hormone in pulmonary fibrosis.
Bao Yan LIU ; Yong WANG ; Yan LIU ; Juan LI ; Ping CUI ; Jin HE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2023;41(1):62-66
Pulmonary fibrosis is end-stage of variety of heterogeneous interstitial lung disease, characterizedby excessive proliferation of fibroblasts and extracellular matrix deposition and destruction of lung parenchyma. Thyroid and lung are derived from the same endodermal cells, thyroid hormone affect the occurrence、development and prognosis of the chronic obstructive pulmonary disease, lung cancer and other lung diseases, This article reviews the role and mechanism of thyroid hormone in pulmonary fibrosis in order to provide new idea for the study of the role and mechanism of thyroid hormone in silicosis.
Humans
;
Pulmonary Fibrosis/pathology*
;
Lung/pathology*
;
Silicosis
;
Lung Diseases, Interstitial
;
Fibroblasts
;
Thyroid Hormones
;
Fibrosis
3.Evaluation of CD3+CD4-CD8- (Double-negative) T Cells in Bronchoalveolar Lavage Fluid: an Effective Tool for Pulmonary Disease Diagnosis.
Hae Bong JANG ; A Jin LEE ; Min Ji KIM ; Chang Ho JEON ; Hun Suk SUH ; Dae Sung HYUN ; Sang Gyung KIM
Laboratory Medicine Online 2015;5(1):20-26
BACKGROUND: Cellular analysis of bronchoalveolar lavage fluid (BALF) is a useful diagnostic tool for interstitial lung diseases (ILDs). The lymphocytes in BALF consist of CD3+CD4+ T cells (T4), CD3+CD8+ T cells (T8), and a few B cells. However, sometimes, an increased number of CD3+CD4-CD8- T cells (double-negative T cells, DNTs) are noted in BALF. It is known that DNTs in the blood are associated with immunoregulation and autoimmune diseases. However, there are only few studies on DNTs in BALF. We evaluated the DNTs in BALF in patients with pulmonary diseases. METHODS: Immunophenotyping results of the BALF obtained from 122 pulmonary disease patients over an 8-yr period were reviewed. T-lymphocyte subsets (T4, T8, and DNT) and inflammatory markers were analyzed for each group of clinical diagnosis. T-lymphocyte percentage of more than 15% of the total cells was defined as BALF lymphocytosis, and DNT percentage of more than 5% of T lymphocytes was defined as high DNT. RESULTS: The most frequent diseases found in the patients were pneumonia (31.6%), autoimmune-related ILDs (18.0%), hypersensitivity pneumonitis (10.7%), and organizing pneumonia (10.7%). However, the occurrence of autoimmune-related ILDs was significantly high (40%) in patients with lymphocytosis and high DNT (P=0.002). All lung cancer patients showed lymphocytosis with high DNT. In addition, CD3-signal intensities of DNTs were significantly higher than those of other T-lymphocyte subtypes (P=0.003). CONCLUSION: The number of DNTs in BALF was increased in patients with autoimmune-related ILDs and lung cancer. High DNTs in BALF are useful as supportive diagnostic tools for autoimmune-related ILDs.
Alveolitis, Extrinsic Allergic
;
Autoimmune Diseases
;
B-Lymphocytes
;
Bronchoalveolar Lavage Fluid*
;
Diagnosis*
;
Humans
;
Immunophenotyping
;
Lung Diseases*
;
Lung Diseases, Interstitial
;
Lung Neoplasms
;
Lymphocytes
;
Lymphocytosis
;
Pneumonia
;
T-Lymphocyte Subsets
;
T-Lymphocytes*
4.A Case of Methotrexate Induced Pneumonitis in a Patient with Rheumatoid Arthritis.
Chan Seok PARK ; Sang Haak LEE ; Kon Ho SHIM ; Wan Uk KIM ; Sook Young LEE ; Seok Chan KIM ; Kwan Hyoung KIM ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 2004;57(3):273-277
Methotrexate is commonly used in rheumatoid arthritis as an anti-inflammatory agent, but treatment with methotrexate can lead to severe side effects, especially pulmonary complication. Interstitial pneumonitis is one of the most important pulmonary adverse effects of methotrexate and most patient present with a subacute febrile illness and peripheral eosinophilia is seen in about a half of patients. Almost all patients have abnormal chest roentgenograms and bibasilar interstitial infiltration with alveolar pulmonary consolidations is the most characteristic finding. Interstitial inflammation with mononuclear cell infiltration is a characteristic pathologic feature and findings that suggest acute hypersensitivity pneumonitis, such as bronchiolitis, granuloma formation with giant cells, and infiltration with eosinophils are often present. Methotrexate-induced pneumonitis is a potentially life threatening and unpredictable complication but it is difficult to make a definite diagnosis in the absence of high index of clinical suspicion. Early recognition and appropriate management may avoid the serious outcome. Herein we report a case of methotrexate-induced pneumonitis in a patient with rheumatoid arthritis.
Alveolitis, Extrinsic Allergic
;
Arthritis, Rheumatoid*
;
Bronchiolitis
;
Diagnosis
;
Eosinophilia
;
Eosinophils
;
Giant Cells
;
Granuloma
;
Humans
;
Inflammation
;
Lung Diseases, Interstitial
;
Methotrexate*
;
Pneumonia*
;
Thorax
5.A case of lymphocytic interstitial pneumonitis.
Hee Jin JUNG ; Eun Rae CHO ; Jae Jung SHIM ; Kwang Ho IN ; Sae Hwa YU ; Kyung Ho KANG ; Nam Hee WON ; Young Ho CHOI
Tuberculosis and Respiratory Diseases 1993;40(5):602-609
No abstract available.
Lung Diseases, Interstitial*
6.A Radiologic Approach to Diffuse Interstitial Lung Disease.
Tuberculosis and Respiratory Diseases 1997;44(4):716-728
No abstract available.
Lung Diseases, Interstitial*
7.A Case of Amiodarone-induced Interstitial Lung Disease.
Byeong Hun KIM ; Won Jong PARK ; Jin Hong CHUNG ; Kwan Ho LEE ; Young Jo KIM ; Bong Sup SHIM ; Hyun Woo LEE
Yeungnam University Journal of Medicine 1994;11(1):186-192
No abstract available.
Lung Diseases, Interstitial*
8.Interstitial Lung Disease.
Tuberculosis and Respiratory Diseases 2006;61(4):321-326
No abstract available.
Lung Diseases, Interstitial*
9.VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature
Yu Jun WONG ; Si Yuan CHEW ; John Chen HSIANG ; Prem Harichander THURAIRAJAH ; Rahul KUMAR ; Eng Kiong TEO ; Roshni Sadashiv GOKHALE ; Imran Bin Mohamed NOOR ; Jessica TAN
Clinical and Molecular Hepatology 2019;25(2):218-222
No abstract available.
Lung Diseases, Interstitial
10.Diagnosis of Interstitial Lung Disease: Comparison of HRCT, Transbronchial Lung Biopsy and Open Lung Biopsy.
Tuberculosis and Respiratory Diseases 1999;46(1):65-74
BACKGROUND: Open lung biopsy(OLB) has conventionally been regarded as the gold standard for the diagnosis in interstitial lung disease. With recent advances in diagnostic technique such as high resolution computed tomography(HRCT), and transbronchial lung biopsy(TBLB) which provide relatively accurate diagnosis of ILD, it is necessary to reevaluate the role of these methods in the diagnosis of ILD. METHODS: We carried out a retrospective analysis of nineteen patients who underwent OLB at Dankook University Hospital for the diagnosis of acute and chronic ILD, between May 1995 and June 1998. By reviewing the medical records, the demographic findings, underlying conditions, HRCT and TBLB findings, OLB diagnosis, therapy after OLB, and complication of OLB were evaluated. RESULTS: 1) Thirteen patients(68.4%) had chronic ILD(symptom duration over 2 weeks prior to OLB), and six patients(31.6%) had acute ILD(symptom duration less than 2 weeks). 2) Specific diagnosis were reached in 92%(12/13) of chronic ILD(5 Bronchiolitis obliterans organizing pneumonia(BOOP), 2 constrictive bronchiolitis, 3 Usual interstitial pneumonia, 1 hypersensitivity pneumonitis, 1 eosinophilic pneumonia), and in all patients of acute ILD(5 acute interstitial pneumonia, 1 pneumocystis carinii pneumonia). 3) HRCT were performed in all patients and a correct first choice diagnosis rate of HRCT was 42%(5/12) in chronic ILD. 4) In chronic ILD patients, 62%(8/13) received specific therapy(steroid therapy in 7 patients and moving in one patient), after OLB, but in acute ILD, all patients received specific therapy(steroid therapy in 5 patients and steroid and antibiotic therapy in one patient) after OLB. 5) The in-hospital mortality after OLB was 5.3%(1/19). CONCLUSION: OLB is an excellent diagnostic technique with relatively low complications in patients with ILD. Therefore OLB should be considered in patients with ILD when the specific diagnosis is important for the treatment, especially in patients with acute ILD.
Alveolitis, Extrinsic Allergic
;
Biopsy*
;
Bronchiolitis Obliterans
;
Diagnosis*
;
Eosinophils
;
Hospital Mortality
;
Humans
;
Idiopathic Pulmonary Fibrosis
;
Lung Diseases, Interstitial*
;
Lung*
;
Medical Records
;
Pneumocystis carinii
;
Retrospective Studies