1.Idiopathic airway-centered interstitial fibrosis: report of two cases.
Xiang-hua YI ; Hai-qing CHU ; Xiao-ming CHENG ; Ben-fang LUO ; Hui-ping LI
Chinese Medical Journal 2007;120(9):847-850
Adult
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Diagnosis, Differential
;
Humans
;
Lung
;
pathology
;
Lung Diseases, Interstitial
;
diagnosis
;
drug therapy
;
pathology
;
Male
;
Middle Aged
2.Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy.
Hyunseop KWON ; Hyun Hee LEE ; Chung Ryul PAIK ; Yun Jeong LIM ; Jeong A PARK
Blood Research 2016;51(4):281-285
No abstract available.
Cytomegalovirus Infections*
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Cytomegalovirus*
;
Drug Therapy*
;
Humans
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Lung Diseases, Interstitial*
;
Megacolon, Toxic*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
4.A Good Outcome for a Case of Chronic Pneumonitis of Infancy.
Jong Min KIM ; Seung Yeon KWON ; Eun Soo KIM ; Myung Hyun SOHN ; Kyu Earn KIM ; Myung Joon KIM ; Sang Ho CHO
Yonsei Medical Journal 2007;48(5):865-867
Chronic pneumonitis of infancy (CPI) is a very rare interstitial lung disease. Its pathological features differ from other types of interstitial pneumonia that occur in adults and children. The mortality rate of CPI is high, even with treatment. We report a case of a 3 month old girl diagnosed with CPI after an open lung biopsy who improved after proper treatment.
Biopsy
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Female
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Humans
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Infant
;
Lung Diseases, Interstitial/*diagnosis/drug therapy/pathology
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Pneumonia/*diagnosis/drug therapy/pathology
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Tomography, X-Ray Computed
5.Lymphocytic Interstitial Pneumonia in Primary Sjogren's Syndrome: A Case Report.
Ji Young KIM ; Sung Hoon PARK ; Seong Kyu KIM ; Dae Sung HYUN ; Yoon Seup KUM ; Kyung Jae JUNG ; Jung Yoon CHOE
The Korean Journal of Internal Medicine 2011;26(1):108-111
Sjogren's syndrome (SS) is an autoimmune disorder in which lymphocytes infiltrate the exocrine glands, resulting in the development of sicca symptoms. Lymphocytes may also invade various other organs and cause diverse symptoms. Interstitial pneumonia has been observed frequently in SS patients. Typically, the pneumonia responds well to systemic steroids, and fatal cases are rare. We experienced a case of lymphocytic pneumonia accompanied by SS and treated with cyclophosphamide pulse therapy, and we present details of the case herein.
Adult
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Humans
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Lung/*pathology
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Lung Diseases, Interstitial/drug therapy/*pathology
;
Lymphocytes/*pathology
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Male
;
Plasma Cells/pathology
;
Sjogren's Syndrome/*pathology
6.A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia.
Chang Hoon HAHN ; Jin Wook MOON ; Jae Hyun CHANG ; Byoung Wook CHOI ; Dong Whan SHIN ; Se Kyu KIM ; Joon CHANG ; Sung Kyu KIM ; Young Sam KIM
Tuberculosis and Respiratory Diseases 2003;55(3):311-316
A 34-year-old man was admitted to our hospital due to fever and cough. He received the combination anti-cancer chemotherapy for testicular tumor, including bleomycin. The chest X-ray showed consolidation and ground glass opacity on the right upper lobe and subpleural areas of other lobes. This condition was initially misdiagnosed as a pneumonia, but consolidation did not disappear after antibiotics treatment. We performed transbronchial lung biopsy and bleomycin induced pulmonary toxicity was confirmed. The bleomycin induced lung injury is the most common chemotherapeutically induced pulmonary disease. Bleomycin induced Bronchiolitis Obliterans Organizing Pneumonia(BOOP) is less common than interstitial pneumonitis and respond well to corticosteroid treatment.
Adult
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Anti-Bacterial Agents
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Biopsy
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Bleomycin
;
Bronchiolitis Obliterans*
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Bronchiolitis*
;
Cough
;
Cryptogenic Organizing Pneumonia*
;
Drug Therapy
;
Fever
;
Glass
;
Humans
;
Lung
;
Lung Diseases
;
Lung Diseases, Interstitial
;
Lung Injury
;
Pneumonia
;
Thorax
7.A non-small cell lung carcinoma patient responded to crizotinib therapy after alectinib-induced interstitial lung disease.
Wenjia SUN ; Jing ZHENG ; Jianya ZHOU ; Jianying ZHOU
Journal of Zhejiang University. Medical sciences 2023;52(5):583-587
A 54-year-old, non-smoking woman was diagnosed as stage ⅣB adenocarcinoma with widespread bone metastasis (cT4N2M1c) in the First Affiliated Hospital, Zhejiang University School of Medicine. Immunohistochemistry result showed the presence of anaplastic lymphoma kinase (ALK) gene rearrangement; next-generation sequencing (NGS) indicated EML4-ALK fusion (E6:A20) with concurrent CCDC148-ALK (C1:A20), PKDCC-ALK (Pintergenic:A20)and VIT-ALK (V15:A20) fusions. After 32 weeks of alectinib treatment, the patient complained cough and exertional chest distress but had no sign of infection. Computed tomography (CT) showed bilateral diffuse ground glass opacities, suggesting a diagnosis of alectinib-related interstitial lung disease (ILD). Following corticosteroid treatment and discontinuation of alectinib, clinical presentations and CT scan gradually improved, but the primary lung lesions enlarged during the regular follow-up. The administration of crizotinib was then initiated and the disease was stable for 25 months without recurrence of primary lung lesions and ILD.
Female
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Humans
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Middle Aged
;
Carcinoma, Non-Small-Cell Lung/drug therapy*
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Crizotinib/therapeutic use*
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Lung Neoplasms/drug therapy*
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Anaplastic Lymphoma Kinase/therapeutic use*
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Lung Diseases, Interstitial/diagnosis*
8.Pathology of Chronic Interstitial Lung Disease.
Korean Journal of Pathology 1998;32(1):1-8
Interstitial lung disease is a generic term for a heterogeneous group of lung disease that primarily affect the interstitium although the disease is not clearly restricted to the interstitium. The majority of interstitial lung diseases represent inflammatory insults to the microscopic anatomic space bounded by the basement membrane of epithelial and endothelial cells, which may occur as slowly developing process and ultimately end up as end-stage honeycomb fibrosis. The currently prevalent classification of interstitial pneumonia with practical utility and easy reproducibility pertaining only to idopathic interstitial pneumonia encompasses several different entities some of which may represent different aspects of the same condition. Honeycomb fibrosis is usually caused by a variety of pulmonary disease including chronic interstitial lung disease. It is important to recognize that usual inter-stitial pneumonia and honeycomb fibrosis are not synonymous. In the era of chemotherapy for malignant tumor, aggressive immunosuppression for autoimmune diseases and transplant recipients and acquired immunodeficiency syndrome, lung disease in the immunocompromised host has been common. Diagnostic lung biopsy becomes increasingly needed because proper treatment of interstitial lung disease relies on correct morphologic diagnosis. This review summarizes the pathologic spectrum of idiopathic interstitial pneumonias together with other inflammatory process with known or suggestive etiologies simulating interstitial pneumonias.
Acquired Immunodeficiency Syndrome
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Autoimmune Diseases
;
Basement Membrane
;
Biopsy
;
Classification
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Diagnosis
;
Drug Therapy
;
Endothelial Cells
;
Fibrosis
;
Idiopathic Interstitial Pneumonias
;
Immunocompromised Host
;
Immunosuppression
;
Lung
;
Lung Diseases
;
Lung Diseases, Interstitial*
;
Pathology*
;
Pneumonia
;
Transplantation
9.Thalidomide Induced Nonspecific Interstitial Pneumonia in Patient with Relapsed Multiple Myeloma.
Myung Hee KANG ; Ji Hyun JU ; Hoon Gu KIM ; Jung Hun KANG ; Kyung Nyeo JEON ; Ho Cheol KIM ; Gyeong Won LEE
The Korean Journal of Internal Medicine 2010;25(4):447-449
A 63-year-old female diagnosed with relapsed multiple myeloma visited our hospital complaining of a persistent cough. Since July 2006, she had been taking 100 mg thalidomide daily and gradually developed shortness of breath and a persistent dry cough. A chest X-ray and computed tomography showed ground glass opacities in both lungs. An open lung biopsy of the right middle lobe under general anesthesia revealed chronic peribronchial inflammation, mild interstitial fibrosis, and intra-alveolar macrophage infiltration, with some hemosiderin features, compatible with non-specific interstitial pneumonia (NSIP). After discontinuing the thalidomide, the patient's symptoms did not deteriorate, although the radiographs did not improve. The patient is alive and well with regular outpatient follow-up without progression of the NSIP.
Female
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Humans
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Lung Diseases, Interstitial/*chemically induced
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Middle Aged
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Multiple Myeloma/*drug therapy
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Thalidomide/*adverse effects/therapeutic use