1.Research progress of pediatric epilepsy combined with depression
Journal of Clinical Pediatrics 2017;35(1):69-72
The morbility of depression in epilepsy patients is relatively high,and children and adolescents are the main population of epilepsy.Because of the specific physical and mental development in children and adolescents,the incidence and medication in these population have their own characteristics.This paper reviews the research progress of the effects,causes,features,and interventions of epilepsy combined with depression in children and adolescents.
2.Role of inflammation in the mechanism of the commorbidity of depression and pain
Jiamin QIN ; Yongjing LU ; Lun CAI
Journal of Medical Postgraduates 2015;(8):893-896
Comorbid depression and chronic pain are highly prevalent in individuals suffering from physical illness .Here, we critically examine that inflammation is the possible mechanism of comorbidity of pain and depression .These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein -coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates toxic kynurenine metabolites .We review the role of in-flammation in the mechanism of the commorbidity of depression and pain .
3.Research Update on 4-Hydroxyisoleucine
Feng GAO ; Qin CAI ; Lun CAI ; Furong LU
Herald of Medicine 2014;(10):1261-1263,1264
Objective 4-Hydroxyisoleucine (4-HIL) is the active component isolated from the seeds of Trigonella foenum-graecum. It exerts broad pharmacological effects such as anti-hyperglycemia,blood lipid lowing,improvement of insulin resistance,etc. As the Chinese traditional medicine,it can be used clinically in treating many diseases such as type 2 diabetes mellitus,dyslipidemia,metabolic syndrome,fatty liver and other diseases. Here the current research status and application prospect on 4-Hydroxyisoleucine were summarized.
5.Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: report of a case.
Jin-fan LI ; Qin YE ; Bo HONG ; Xin GAO ; Kan-lun XU
Chinese Journal of Pathology 2011;40(9):638-639
Adenocarcinoma, Papillary
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metabolism
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pathology
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secondary
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surgery
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Adult
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Diagnosis, Differential
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Female
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Follow-Up Studies
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Humans
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Keratin-7
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metabolism
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Keratins
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metabolism
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Lung Neoplasms
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metabolism
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pathology
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secondary
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Nasopharyngeal Neoplasms
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metabolism
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pathology
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surgery
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Nuclear Proteins
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metabolism
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Thyroid Neoplasms
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metabolism
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pathology
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secondary
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Thyroid Nuclear Factor 1
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Transcription Factors
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metabolism
7.Effects of sin-1 on growth and cytoskeleton of endothelial cells in vitro
Yun-Lai LIU ; Lun-Shan XU ; Zhong-Xiang YAO ; Wen-Qin CAI
Journal of Third Military Medical University 2001;23(4):422-424
Objective To investigate the mechanism affecting on permeability of vascular endothelial cell by nitric oxide (NO). Methods Series concentration of sin-1(a donor of NO) were added to ECV 304, a cell line of human umbilical vein endothelium. Cell growth and expression of f-actin, a cytoskeleton protein were observed. Results Cell growth was inhibited with a dose from 6.25 to 100 μmol/L and was caused to death at the concentration of 50 to 100 μmol/L by sin-1. The expression of f-actin was suppressed obviously after cultured with 100 μmol/L sin-1 for 4 hours. Conclusion It suggests that anomaly increased NO can increase permeability of blood vessels by suppressing the expression of f-actin, inhibiting cell growth or even resulting in cell death.
8.Literature mining and bioinformatic analysis of dysregulated genes in hypertrophic scar.
Chen HUANG ; Bo-Lun LI ; Ze-Lian QIN
Chinese Journal of Plastic Surgery 2011;27(6):453-460
OBJECTIVETo explore the pathogenesis mechanism of hypertrophic scar (HS) and the effective means for its clinical treatment, the difference of the gene expressions between HS and normal skin was compared.
METHODSThe differentially expressed genes between HS and normal skin were obtained by mining PubMed. The dysregulated genes in HS were analyzed by a series of bioinformatics methods, including protein-protein interaction networks, pathways, Gene Ontology and functional annotation clustering analysis.
RESULTSA total of 55 dysregulated genes in HS was identified (46 up-regulated genes and 9 down-regulated genes). Fifty-one genes were found to encode proteins with interaction network, including up-regulated genes TGFB1, FN1, JUN, COL1A1, CTGF, VEGFA, FOS, COL3A1, IGF1, IL4, PELO, SMAD2, TIMP1, PCNA, and ITGA4 and down-regulated genes ITGB1 and DCN as the central nodes for this network. The dysregulated genes in HS involved in a variety of biological pathways, such as focal adhesion formation, integrin signal transduction, and tumor formation. Furthermore, the dysregulated genes in HS played the important roles in biological processes of cell surface receptor linked signal transduction, tissue development, cell proliferation and apoptosis, and macromolecule biosynthetic process, as well as in molecular function of calcium ion binding, double-stranded DNA binding, heparin binding, promoter binding and MAP kinase activity. The results of functional annotation clustering analysis revealed that the dysregulated genes in HS involved in epidermis development, angiogenesis, and apoptosis.
CONCLUSIONSuch key genes as TGFB1, FN1, and JUN, along with the pathways, biological processes and molecular functions involving epidermis development, angiogenesis, and extracellular matrix-integrin-focal adhesion signal transduction may play the important roles in the development of HS. The investigations of the dysregulated genes in HS could provide the new targets for clinical treatment.
Cicatrix, Hypertrophic ; genetics ; Cluster Analysis ; Computational Biology ; Data Mining ; Gene Expression ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans
9.Method of bubble under water capsulorhexis in small incision used in mature cataract operation
Xiao-Ping, ZHOU ; Guo-Ping, KUANG ; Yu-Lun, OU ; Shao-Ying, FENG ; Mu, QIN ; Xiao-Ping, ZHAN
International Eye Science 2016;16(10):1872-1874
AIM: To observe application of underwater bubble method capsulorhexis overmature period to improve the small incision cataract surgery, so as to explore the clinical value of the surgical method.
● METHODS: From Jul. 2012 to Mar. 2016 at the grassroots of blindness 58 people fail in the 66 eyes overmature period of cataract were randomly divided into underwent capsulorhexis by underwater bubble method to improve the small incision cataract surgery group ( 36 eyes of 30 cases ) and conventional viscoelastic agent underwent capsulorhexis small incision cataract surgery group (30 eyes of 28 cases).
● RESULTS: A total of 66 eyes in success rate of continuous circular capsulorhexis: 92% ( 33/36 eyes ) of underwater bubble method, method of viscoelastic agent only 40% ( 12/30 eyes ) . Two groups of cases of postoperative corneal endothelial cell density are compared with preoperative significantly reduced, no significant statistical difference between the two groups(P>0. 05).
● CONCLUSION: Underwater bubble method capsulorhexis difficult to overmature period of cataract surgery capsulorhexis solution is a better way.
10.Establishment of the prediction model for ischemic cardiovascular disease of elderly male population under current health care program
Jin-Hong CHEN ; Hai-Yun WU ; Kun-Lun HE ; Yao HE ; Yin-He QIN
Chinese Journal of Epidemiology 2010;31(10):1166-1169
Objective To establish and verify the prediction model for ischemic cardiovascular disease(ICVD)among the elderly population who were under the current health care programs. Methods Statistical analysis on data from physical examination, hospitalization of the past years, from questionnaire and telephone interview was carried out in May, 2003. Data was from was randomly selected to generate both module group and verification group. Baseline data was induced to make the verification group into regression model of module group and to generate the predictive value. Distinguished ability with area under ROC curve and the predictive veracity were verified through comparing the predictive incidence rate and actual incidence rate of every deciles group by Hosmer- Lemeshow test. Predictive veracity of the prediction model at population level was verified through comparing the predictive 6-year incidence rates of ICVD with actual 6-year accumulative incidence rates of ICVD with error rate calculated. Results The samples included 2271 males over the age of 65 with 1817 people for modeling population and 454 for verified population.All of the samples were stratified into two layers to establish hierarchical Cox proportional hazard regression model, including one advanced age group(greater than or equal to 75 years old), and another elderly group(less than 75 years old). Data from the statically analysis showed that the risk factors in aged group were age, systolic blood pressure, serum creatinine level, fasting blood glucose level, while protective factor was high density lipoprotein; in advanced age group, the risk factors were body weight index, systolic blood pressure, serum total cholesterol level, serum creatinine level, fasting blood glucose level, while protective factor was HDL-C. The area under the ROC curve (AUC)and 95%CI were 0.723 and 0.687-0.759 respectively. Discriminating power was good. All individual predictive ICVD cumulative incidence and actual incidence were analyzed using Hosmer-Lemshow test, x 2=1.43, P=0.786, showing that the predictive veracity was good.Conclusion The stratified Cox Hazards Regression model was used to establish prediction model of the aged male population under a certain health care program. The common prediction factor of the two age groups were: systolic blood pressure, serum creatinine level, asting blood glucose level and HDL-C. Thc area under the ROWC curve of the verification group was 0.723, showing that the distinguished ability was good and the predict ability at the individual level and at the group level were also satisfactory. It was feasible to using Cox Proportional Hazards Regression Model for predicting the population groups.