AIM: To select the macroresin used for purification of total saponins of Polygala Fallax Hemsl. METHODS: The adsorption and desorption capability of five different macroresins LSA-7,LSA-10,LSA-30,D-101A and HPD-100 in static state were studied by UV. RESULTS: nonpolar LSA-30 and HPD-100 macroporus resin had the optimum comprehensive properties of adsorption and desorption. CONCLUSION: The experimental results provide the basis for selection of macroporus resins used to purify total saponins of Polygala Fallax Hemsl.