An 84-year-old woman had an ovoid shallow ulcer with an elevated, indurated, pigmented border on the left cheek. Histological examination revealed a moderately differentiated squamous cell carcinoma and a solar keratosis with abundant melanocytes and melanin pigment. Ultrastructurally, the keratinocytes contained numerous melanosomes in their cytoplasms and the melanocytes in the squamous cell carcinoma and the solar keratosis had mature melanosomes.
Aged, 80 and over ; Carcinoma, Squamous Cell* ; Cheek ; Cytoplasm ; Epithelial Cells* ; Female ; Humans ; Keratinocytes ; Keratosis ; Melanins ; Melanocytes ; Melanosomes ; Ulcer

We report a case of a congenital, melanocytic nevus showing spontaneous regression. At birth, a pigmented lesion, 4 × 6.5cm, was already present on the scalp. At the age of 20 days, the center of the lesion became crusted with a purulent discharge. Following healing of the inflammed lesion, the nevus showed a tendency to regress, starting from the previously inflammed site. At the age of 11 months, the nevus showed marked regression, leaving an atrophic and depigmented center with pea-sized papules and a thin, pigmented rim. Skin sections taken from the central depigmented area showed marked fibrosis and scanty nevus cell nests in the dermis. Histological examination of the pea-sized papule in the center of the lesion repealed large epithelioid cells with abundant cytoplasm dispersed between the collagen fibers; it resembled a spindle cell and epithelioid cell nevus with epithelioid cells predominating. There were no clinical or histologically malignant changes.
Collagen ; Cytoplasm ; Dermis ; Epithelioid Cells ; Fibrosis ; Nevus ; Nevus, Pigmented* ; Parturition ; Scalp ; Skin