1.Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis.
Francisco Javier JIMENEZ-BALDERAS ; Janete GARCIA-JAIMES ; Rita RIOS ; Abraham ZONANA-NACACH ; Raquel TAPIA-ROMERO ; Nayeli VILLANUEVA ; Patricia MENDEZ-SAMPERIO ; Jorge Luis DE-LA-ROSA-ARANA
Korean Journal of Ophthalmology 2014;28(3):207-212
PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU. METHODS: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions. RESULTS: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS. CONCLUSIONS: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
Acute Disease
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Adult
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Aged
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Animals
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Antibodies, Anti-Idiotypic/*isolation & purification
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Enzyme-Linked Immunosorbent Assay
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Eye Infections, Parasitic/complications/*immunology/parasitology
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Female
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Humans
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Immunoglobulin G/*immunology
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Male
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Middle Aged
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Seroepidemiologic Studies
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Spondylitis, Ankylosing/*complications/immunology/parasitology
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Toxocara canis/*immunology/isolation & purification
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Toxocariasis/complications/*immunology/parasitology
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Uveitis, Anterior/complications/*immunology/parasitology
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Young Adult
2.A Randomized, Open-Label Assessment of Response to Various Doses of Atomoxetine in Korean Pediatric Outpatients with Attention-Deficit/Hyperactivity Disorder.
Soochurl CHO ; Soyoung Irene LEE ; Hanik YOO ; Dong Ho SONG ; Dong Hyun AHN ; Dong Won SHIN ; Sun Young YUM ; Richard WALTON ; Luis MENDEZ
Psychiatry Investigation 2011;8(2):141-148
OBJECTIVE: This multicenter, randomized, open-label, parallel trial aimed to provide a detailed dose-response profile for atomoxetine in Korean pediatric outpatients with attention-deficit/hyperactivity disorder (ADHD). METHODS: Male and female outpatients aged 6-18 years with ADHD meeting symptom severity criteria of 1.5 standard deviations above age and gender norms on the ADHD Rating Scale-IV-Parent: Investigator-Administered and Scored (ADHDRS-IV-Parent: Inv), and a Clinical Global Impression-ADHD-Severity score > or =4 were randomized to atomoxetine (mg/kg/day) 0.2 fixed, 0.5 fixed or 0.5 (7 days), 0.8 (7 days) then 1.2 for 28 days. The primary efficacy measure was change in ADHDRS-IV-Parent: Inv total score after 6 weeks of atomoxetine treatment. RESULTS: Of 153 randomized patients, 83.7% were male and mean age was 9.8 (SD+/-2.4) years. The completion rate was 86.9%. A graded dose response was apparent with mean change in ADHDRS-IV-Parent: Inv total scores of -9.6, -12.3 and -14.5 with atomoxetine 0.2, 0.5 and 1.2 mg/kg/day, respectively (p=0.024 - F-test). Moreover, a greater reduction in ADHD symptoms, as assessed by mean change from baseline to endpoint CGI-S and mean CGI-ADHD-Improvement at endpoint, was also observed with increasing atomoxetine dose. More patients receiving atomoxetine 1.2 mg/kg/day reported > or =1 treatment-emergent adverse event/s (58.3%) compared with 0.5 (40.7%; p=0.11) or 0.2 mg/kg/day (29.4%; p=0.005). These were generally mild to moderate. CONCLUSION: Atomoxetine was found to be safe and well tolerated at all doses administered in Korean pediatric ADHD patients, and 1.2 mg/kg/day was an efficacious dose in this population.
Aged
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Female
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Humans
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Korea
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Male
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Outpatients
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Propylamines
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Atomoxetine Hydrochloride
3.Surgical Management of a Type II Extracranial Internal Carotid Aneurysm near to the Skull Base
Miguel A. MENDEZ-SOSA ; Emmanuel CONTRERAS-JIMENEZ ; Javier E. ANAYA-AYALA ; Montserrat W. MIRANDA-RAMIREZ ; Gabriel LOPEZ-PENA ; Luis H. ARZOLA ; Santiago Mier y TERAN-ELLIS ; Hugo LAPARRA-ESCARENO ; Carlos A. HINOJOSA
Vascular Specialist International 2021;37(3):27-
True aneurysmal disease in the carotid arteries is very uncommon, but individuals with this pathology face the grave risk of thromboembolism, which may consequently lead to cerebrovascular accidents. Clinical knowledge remains relatively limited owing to its rarity. We present the case of a 41-year-old obese female with a type II right extracranial internal carotid artery aneurysm incidentally found during imaging work-up. She underwent open surgical reconstruction with an autologous interposition graft from the common carotid artery to the internal carotid artery at the base level of the skull. Her postoperative period was uneventful, and the patient was discharged on postoperative day five with aspirin. At 12 months of follow-up, the patient remained symptom-free without complications.
4.Surgical Management of a Type II Extracranial Internal Carotid Aneurysm near to the Skull Base
Miguel A. MENDEZ-SOSA ; Emmanuel CONTRERAS-JIMENEZ ; Javier E. ANAYA-AYALA ; Montserrat W. MIRANDA-RAMIREZ ; Gabriel LOPEZ-PENA ; Luis H. ARZOLA ; Santiago Mier y TERAN-ELLIS ; Hugo LAPARRA-ESCARENO ; Carlos A. HINOJOSA
Vascular Specialist International 2021;37(3):27-
True aneurysmal disease in the carotid arteries is very uncommon, but individuals with this pathology face the grave risk of thromboembolism, which may consequently lead to cerebrovascular accidents. Clinical knowledge remains relatively limited owing to its rarity. We present the case of a 41-year-old obese female with a type II right extracranial internal carotid artery aneurysm incidentally found during imaging work-up. She underwent open surgical reconstruction with an autologous interposition graft from the common carotid artery to the internal carotid artery at the base level of the skull. Her postoperative period was uneventful, and the patient was discharged on postoperative day five with aspirin. At 12 months of follow-up, the patient remained symptom-free without complications.
5.A preliminary study of platelet hyperactivity in the chronic indeterminate phase of Chagas’ disease
Flavio Rojas Castillejos ; Laura Perez-Campos Mayoral ; Gabriel Mayoral Andrade ; Maria Teresa Hernandez-Huerta ; Socorro Pina-Canseco ; Ruth Martinez Cruz ; Efrain Herrera Colmenares ; Eduardo Perez-Campos Mayoral ; Paz Maria Salazar ; Martha Bucio Torres ; Margarita Cabrera Bravo ; Margarito Martinez Cruz ; Carlos Matí ; as Cervantes ; Roxana Diaz Albarraz ; Joel Lopez Matias ; Gabriela Ines Rios Arias ; Gema Hrnandez Bernardino ; Ernesto Perez Matus ; Rosalinda Mendez Trujillo ; Luis Manuel Sanchez Navarro ; Alma Dolores Perez Santiago ; Eduardo Perez Campos
Tropical Biomedicine 2018;35(3):678-683
The chronic indeterminate phase of Chagas’ disease is asymptomatic despite
positive test results for antibodies specific to Trypanosoma cruzi. CD62P-APC (P-selectin)
and PAC-1 FITC (GpIIb/IIIa) may improve diagnosis as biomarkers of platelet activity. Nine
asymptomatic seropositive subjects, previously untreated, were selected from a blood bank
within a year of Chagas’ disease detection, in addition to a control group of four. All subjects
were evaluated by flow cytometry for CD62P, PAC-1 and CD41, and in a complementary
study, by Tissue Doppler Echocardiography for isovolumic relaxation times (IVRT) and E/A
ratios. The subjects were classified as positive or negative for CD62P and PAC-1 by a cut off
obtained from their mean±2SD. For IVRT and E/A ratios, cut offs were obtained from the
American Society of Echocardiography and the European Association of Cardiovascular
Imaging recommendations. Fisher’s exact test was used for associated findings. Pre-test and
post-test probability, sensitivity, specificity, positive and negative predictive values and
likelihood ratios were calculated. Abnormalities were expressed as platelet hyperactivity
and ventricular dysfunction in CD62P, PAC-1, IVRT and E/A ratios. CD62P appears to have
greater sensitivity (0.75) and PAC-1, more accurate specificity (0.75), which may explain
thrombotic events in Chagas’ disease. We recommend the use of CD62P and PAC-1 as biomarkers
of platelet hyperactivity in patients in the chronic indeterminate phase of Chagas’ disease.