Objective To retrospective analysis of the clinical effect and complications of the semi-laminectomy approach on the treatment of intra-spinal tumor.To summarize the endoscopic treatment experience of intra-spinal tumor.Methods To retrospective analysis of the clinical data of 24 cases with intra-spinal tumor in Shanxi Provincial People's Hospital from January 2008 to September 2015.The diagnosis of the intra-spinal tumor was confirmed by preoperative MRI examination.Intraoperative application of endoscopic surgery in the resection of tumor.Longterm followed up of patient was implemented and observe the efficacy and complications after surgery.Results Postoperative symptoms of all patients have different degrees of improvement,the degrees of sensory disorder was reduce,the limb muscle strength was increased and alleviate the damages of nerve electrophysiology.No serious complications were found after operation.Of the 24 patients,17 cases were total resection of the tumor and 7 cases were subtoal resection of the tumor.Tethered cord release was operated in patients with tethered spinal cord.Conclusions Endoscopic resection assisted semi-laminectomy approach of intra-spinal tumor has slight damage to the surround structures and the impact to the anatomy of the spine was small.Endoscopic assisted semi-laminectomy approach may have siginficant clinical effect on intra-spinal tumor,and have good security.