1.The Diagnostic Value of Contrast-enhanced CT Scans for Traumatic Splenic Rupture
Yuewu ZHANG ; Xisong ZHU ; Weixian WU ; Lugang ZHANG
Journal of Practical Radiology 1991;0(03):-
Objective To evaluate the diagnostic value of contrast-enhanced CT scans in diagnosis of traumatic splenic rupture. Methods The findings of unenhanced and contrast-enhanced CT scans of 34 cases with traumatic splenic rupture confirmed by operation were retrospectively reviewed. Results Of the 34 patients, the diagnoses of splenic rupture on unenhanced CT scans were certain in 23 patients and uncertain in 6 patients. No abnormalities were found in 5 patients(sensitivity 85.3%, specificity 67.6%). After intravenous administration of contrast material, all of the patients were diagnosed as splenic rupture(sensitivity 100%,specificity 100%).Conclusion Contrast-enhanced CT is important in diagnosis of traumatic splenic rupture and can obviously improve the diagnostic accuracy. It provides reliable information for clinical treatment.
2.Image features of non-ossifying fibroma and comparative study in pathology
Zhiwei YE ; Xisong ZHU ; Lugang ZHANG ; Chaogen JIANG
Chinese Journal of Postgraduates of Medicine 2011;34(z2):28-30
Objective To improve the accuracy of diagnosis and differential diagnosis of nonossifying fibroma (NOF) by comparing with the image features of X-ray and CT and pathological characteristics,Methods The images of X-ray and CT of 28 patients underwent surgery and pathological confirmed NOF were studied retrospectively.Results NOF often occurred in the metaphysis of long bone or backbone with mild clinical symptoms.Eighteen lesions occurred in tibia,9 in femur and 1 in humerus.In 19 cortical cases,there was a single room or multiple rooms translucent zone in cortex or subcortex with dense surrounding.In 9 medullary cases,lesions as a single room or multiple rooms ranslucent zone with dense surrounding developed in the central area of the bone with thinning corex slightly bulg ed to periphery.Conclusion The images of NOF have some characteristic.X-ray and CT are very useful tools in diagnosis of NOF.Thin layer scanning and multiplanar reconstruction of multi-layers spiral CT can more clearly show the imaging features of NOF.
3.Study on DNA damage in rat bone marrow cells induced by mustard gas.
Yongfei ZHU ; Lugang LI ; Xuebin GUO ; Meng XIA ; Ning XUE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(5):353-355
OBJECTIVETo study the damage of DNA in rat bone marrow cells induced by mustard gas.
METHODMale SD rats were randomly divided into six groups. Physiological saline, propylene glycol and mustard gas(0.2, 0.4, 0.8, 1.6 mg/kg) were given separately by i.p. injection. 5 rats in each group were killed after 0, 24, 48, 72 hours of exposure. The DNA damage in rat bone marrow cells was assayed by single cell gel electrophoresis (SCGE).
RESULTSThere is no significant difference of DNA damage among all groups at 0 h(P > 0.05). The rates of DNA migration and the lengths of DNA migration of the rat bone marrow cells in propylene glycol group at 24, 48, 72 hours were 15.4% +/- 0.21%, 16.0% +/- 0.19%, 15.7% +/- 0.23% and (11.4 +/- 0.2), (13.5 +/- 0.3), (12.8 +/- 0.2) micron respectively, and they were significantly higher than those of physiological saline group at the same time(P < 0.05). The rates of DNA migration and the lengths of DNA migration of the rat bone marrow cells in mustard gas groups at 24, 48, 72 hours were significantly higher than those in physiological saline group and propylene glycol group at the same time(P < 0.05).
CONCLUSIONMustard gas could induce DNA damage in rat bone marrow cells. The damage was likely to rise as the dose increased and was time-dependent.
Animals ; Bone Marrow Cells ; drug effects ; ultrastructure ; Comet Assay ; DNA Damage ; Dose-Response Relationship, Drug ; Male ; Mustard Gas ; toxicity ; Rats ; Rats, Sprague-Dawley ; Time Factors
4.Research progress on ferroptosis in the treatment of bladder cancer
Jingping QIU ; Lugang ZHU ; Yuanwei CHEN ; Minghong ZHOU ; Yuwan ZHAO ; Jianjun LIU
Journal of Modern Urology 2024;29(9):830-835
Ferroptosis is a new programmed cell death dependent on iron ions.Ferroptosis can be induced by endogenous or exogenous pathways, and cells exhibit specific cell morphological signs and are regulated by a variety of molecular mechanisms.In recent years, more and more studies have shown that ferroptosis plays an important role in the treatment of cancer.This article summarizes the mechanism of ferroptosis in bladder cancer and the regulation of cancer cells, as well as the role of ferroptosis-related factors, non-coding RNA regulation, N6-methyladenosine (m6A), amino acid metabolism and autophagy dependent ferroptosis in the growth and proliferation of bladder cancer, with a view to provide new strategies for the treatment of bladder cancer.